Navigation Links
RNA map provides first comprehensive understanding of alternative splicing

out to be alternatively spliced in a Nova-dependent way. Of those, all 30 fit the rules of the RNA map.

"In other words, every transcript that we could predict as a Nova-regulated alternatively spliced RNA fit the prediction of this map," says Darnell. "Half of them were inhibited by Nova and half were enhanced in their exon use by Nova, and every one very cleanly fit the pattern."

The researchers also simulated alternative splicing in the test tube, mixing purified RNA and a splicing extract. When purified Nova was added to the extracts, it bound to the mRNA clusters, altering the outcome of the how the splicing machinery was able to assemble in a manner that again conformed to the predictions of the RNA map. In one case Nova blocked specific components of the splicing machinery, in another it enhanced the ability of this machinery to assemble the right way and use an alternatively spliced site that is otherwise poorly utilized.

By offering a global understanding of how alternative splicing works across the genome, the map has implications for the treatment of a growing list of human neurologic diseases in which RNA regulation, and particularly RNA splicing, has been implicated as the primary cause, including certain types of cancer and a number of brain and muscle disorders.

"Given that the complexity of the brain is orders and orders of magnitude more complex than the number of genes we have, one of the intriguing things about alternative splicing is that a relatively small number of regulatory splicing factors acting in concert on a single transcript can potentially generate a large number of different protein variants," says Darnell.

"There is a converging set of observations indicating that as neurologic diseases are better understood, alternative splicing is going to play an important role in generation of disease and therefore an important role in normal generation of cognitive function," he adds. "Our new
'"/>

Source:Rockefeller University


Page: 1 2 3 4

Related biology news :

1. MetaChip provides quick, efficient toxicity screening of potential drugs
2. NYU and MSKCC research provides model for understanding chemically induced cancer initiation
3. Nature provides inspiration for important new adhesive
4. New plant DNA libraries provides massive boost to worlds plant researchers
5. NASA satellite data provides rapid analysis of Amazon deforestation
6. Study provides insight into cellular defenses against genetic mutation
7. Customized gene chip provides rapid detection of genetic changes in childrens cancer
8. Vaccine provides 100 percent protection against avian flu virus in animal study
9. New hybrid virus provides targeted molecular imaging of cancer
10. Ancient DNA provides clues to the evolution of social behavior
11. Brittlestar provides new model for stem cell research
Post Your Comments:
(Date:12/22/2014)... , Dec. 22, 2014  NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce market, announces ... Apollo Robbins for the 2015 International CES debut of ... Robbins will be at the NXT-ID booth January 6th ...
(Date:12/19/2014)... , Dec. 18, 2014 Research and Markets ... "Micro Market Monitor: North America Perimeter Security Systems Market" ... The North American perimeter security market is ... to 2019. Although the U.S. market holds a larger share ...
(Date:12/17/2014)... 15, 2014 The Defense Logistics Agency is insourcing ... prevent counterfeit microcircuits from entering into its supply chain. ... microcircuit anti-counterfeit initiative dubbed DNA marking. The capability will ... reliability throughout the supply chain. The new quality control ...
Breaking Biology News(10 mins):NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 4Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3
... Leicester and University of California Los Angeles (UCLA) have ... in the body. They have filed two patents ... catalyst for lowering levels of ,bad, cholesterol. Two ... of the regulation of low-density lipoprotein (LDL) or "bad" ...
... have created a scientifically rigorous analogy that shows the similarities ... structure of a melody, proving that the structure of each ... The step-by-step comparison begins with the primary building blocks ... wave and moves up to the level of a ...
... magnetic resonance imaging measures were associated with prognostic ... imaging for prediction of disease prognosis and stratification ... data presented at the 2011 CTRC-AACR San Antonio ... "Breast cancers are heterogeneous, and different subtypes of ...
Cached Biology News:New advance announced in reducing 'bad' cholesterol 2Researchers link patterns seen in spider silk, melodies 2Researchers link patterns seen in spider silk, melodies 3MRI may be noninvasive method to measure breast cancer prognosis 2
(Date:12/24/2014)... and NEW YORK , Dec. 24, ... company advancing patient care in critical areas, announced the closing ... stock, and warrants to purchase up to an aggregate 3,500,000 ... per share and $.01 per warrant.  The warrants have a ...
(Date:12/24/2014)... Dec. 24, 2014   BioLife Solutions , Inc. (NASDAQ: ... proprietary clinical grade hypothermic storage and cryopreservation ... for cells and tissues  ("BioLife" or the "Company"), today announced ... on May 4, 2015 (the "Annual Meeting"). Because ...
(Date:12/24/2014)... 2014 GMO corn cases filed across the ... the process of being consolidated in a Kansas federal court ... AG MIR 162 Corn Litigation, MDL No. 2591 in the ... of the Syngenta GMO corn multidistrict litigation (MDL) has been ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 ... designed to introduce cutting edge communication technology, provide ... platform upgrades. This webinar series demonstrates online communication ... to leverage web conferencing’s most innovative and powerful ...
Breaking Biology Technology:PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3BioLife Solutions Sets Date for Annual Meeting of Stockholders 2Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3
... A/S Summons Annual General Meeting Summary: Genmab ... COPENHAGEN, Denmark, April 7 Genmab A/S (OMX:,GEN) summon the ... CEST at the Radisson SAS Scandinavia Hotel, Amager Boulevard 70, ... Board of Directors on the Company,s activities during,the year., ...
... contains two different types of components: magnetic components, which ... operations. A University of Missouri researcher, as part of ... two functions in a single hybrid material. This new ... functions and is expected to permit the design of ...
... Angiotech Pharmaceuticals,Inc. (NASDAQ: ANPI , TSX: ANP), ... today that the first New Zealand patient,was treated ... in December 2007. A second patient was treated ... first drug-eluting stent for peripheral,arterial disease (PAD) and ...
Cached Biology Technology:Genmab A/S - Notice to Convene Annual General Meeting 2Genmab A/S - Notice to Convene Annual General Meeting 3Genmab A/S - Notice to Convene Annual General Meeting 4Genmab A/S - Notice to Convene Annual General Meeting 5Genmab A/S - Notice to Convene Annual General Meeting 6Genmab A/S - Notice to Convene Annual General Meeting 7Hybrid computer materials may lead to faster, cheaper technology 2Angiotech announces commercial launch of Cook Medical's Zilver(R) PTX(TM) drug-eluting peripheral stent in New Zealand 2Angiotech announces commercial launch of Cook Medical's Zilver(R) PTX(TM) drug-eluting peripheral stent in New Zealand 3Angiotech announces commercial launch of Cook Medical's Zilver(R) PTX(TM) drug-eluting peripheral stent in New Zealand 4
ImageQuant 300, 1 EA. Category: ImageQuant CCD Imagers....
Recombinant Rat PTX2/SAP...
HybriWell™ hybridization sealing system, 22 mm x 22 mm chamber, 0.15 mm deep *set of 100*...
HybriWell™ hybridization sealing system, 20 mm diameter chamber, 0.15 mm deep *set of 100*...
Biology Products: