Navigation Links
RNA interference stops colon cancer spread in mice

Using one of the newest and most powerful tools of biomedical science, University of Texas Medical Branch at Galveston (UTMB) researchers have scored a dramatic success in the battle against colorectal cancer.

The scientists were the first to use what are known as "small interfering RNAs" to block the spread of human colorectal cancer cells implanted in laboratory mice. Small interfering RNAs (siRNAs), first described in 2001, are tiny bits of genetic material that can prevent the translation of genes into proteins -- including specific proteins involved in biochemical reactions that promote cancer and other diseases.

According to the federal Centers for Disease Control and Prevention, colorectal cancer is the country's second leading cancer killer. In 2002, the most recent year for which statistics are available, 70,651 men and 68,883 women were diagnosed with the colorectal cancer in the United States; 28,471 men and 28,132 women died from the disease.

"What's exciting about this is that by using siRNAs we were able to selectively block components of the PI3K pathway, a biochemical pathway that is activated in a number of cancers, and suppress the spread of colon cancer in experimental animals," said UTMB professor of surgery B. Mark Evers, senior author of a paper on the research published in the June issue of Annals of Surgery. "Over the last couple of years people have talked a lot about cell-culture studies of siRNAs, but only a handful of labs have pushed it to animal models, which we need to do before going on to clinical trials."

To study the effects of siRNAs targeted against the PI3K pathway in mice, the researchers used a well-established technique in which human colorectal cancer cells were implanted into the spleens of genetically engineered immune-deficient "nude" mice. They then injected siRNAs designed to prevent the production of two specific PI3K proteins into the mice. The result was a major reduction in the spread of colorectal cancer to the liver.

Evers and the paper's other authors -- UTMB research fellows Piotr Rychahou and Lindsey Jackson and pathology professor Srinivasan Rajaraman -- also conducted a detailed analysis of the PI3K pathway's components and did experiments to determine how their siRNAs would affect colorectal cancer cell cultures. Scientists have already developed chemical inhibitors to attack the pathway (some of which are now in clinical trials), but toxic side effects limit their use.

"When we treat with siRNA and then follow the treatment with standard chemotherapeutic agents, we can markedly increase the rate at which cancer cells are killed," Evers said. "Since we have not seen any toxicity with these siRNAs in our mice, we think we can potentially also use them as a way to sensitize tumors and launch a combined attack that will allow us to achieve much better results with reduced side effects."


'"/>

Source:University of Texas Medical Branch at Galveston


Related biology news :

1. Scientists identify genetic pathways essential to RNA interference
2. Silence the gene, save the cell: RNA interference as promising therapy for ALS
3. Scientists identify genetic pathways essential to RNA interference
4. Used in a new way, RNA interference permanently silences key breast cancer gene
5. Cocaine high caused by interference in neuronal receiving stations
6. One bacteria stops another on contact
7. Anthrax stops body from fighting back, study shows
8. New compound stops brain cell degeneration in Alzheimers disease
9. Insulin receptor stops progression of Alzheimers disease
10. MIT material stops bleeding in seconds
11. Natural protein stops deadly human brain cancer in mice
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/5/2016)... 5, 2016 http://www.researchandmarkets.com/research/5kvw8m/global_facial ... "Global Facial Recognition Market 2016-2020" ... http://www.researchandmarkets.com/research/5kvw8m/global_facial ) has announced the addition of ... report to their offering. --> ... has announced the addition of the ...
(Date:2/3/2016)... 2016 --> ... "Automated Fingerprint Identification System Market by Component (Hardware and ... & Finance, Government, Healthcare, and Transportation) and Geography - ... is expected to be worth USD 8.49 Billion by ... and 2020. The transformation and technology evolution from the ...
(Date:2/2/2016)... , Feb. 2, 2016  BioMEMS devices ... primarily focused on medical screening and diagnostic ... parameters. Wearable devices that facilitate and assure ... of movement are being bolstered through new ... biomedical signal acquisition coupled with wireless connectivity ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... ASAE is introducing a hybrid membership model ... the option of joining or renewing through an organizational ... staff size, every employee in any size association or ... all available member benefits.   John H. ... options will allow organizations of any size and their ...
(Date:2/10/2016)... New York (PRWEB) , ... ... ... Inc. (NASDAQ: REGN) today announced that it has joined the Human Vaccines ... immunotherapies for infectious diseases and cancer. , The Human Vaccines Project ...
(Date:2/10/2016)... Wash., Feb. 10, 2016  IsoRay, Inc. (NYSE MKT: ... brachytherapy and medical radioisotope applications for the treatment of ... today announced its financial results for the second quarter ... 31, 2015. --> ... quarter of fiscal 2016, which ended December 31, 2015, ...
(Date:2/10/2016)... plc (NYSE: AGN ) a leading global pharmaceutical ... CEO and President, will be featured as the keynote ... Capital Markets Healthcare Conference on Tuesday, February 23, 2016 ... Hotel in New York, NY . ... accessed on Allergan,s Investor Relations web site at ...
Breaking Biology Technology: