Navigation Links
RNA enzyme structure offers a glimpse into the origins of life

Researchers at the University of California, Santa Cruz, have determined the three-dimensional structure of an RNA enzyme, or "ribozyme," that carries out a fundamental reaction required to make new RNA molecules. Their results provide insight into what may have been the first self-replicating molecule to arise billions of years ago on the evolutionary path toward the emergence of life.

In all forms of life known today, the synthesis of DNA and RNA molecules is carried out by enzymes made of proteins. The instructions for making those proteins are contained in genes made of DNA or RNA (nucleic acids). The circularity of this process poses a challenge for theories about the origins of life.

"Which came first, nucleic acids or proteins? This question once seemed an intractable paradox, but with the discovery of ribozymes, it is now possible to imagine a prebiotic 'RNA World' in which self-replicating ribozymes accomplished both tasks," said William Scott, associate professor of chemistry and biochemistry at UC Santa Cruz.

Scott and postdoctoral researcher Michael Robertson determined the structure of a ribozyme that joins two RNA subunits together in the same reaction that is carried out in biological systems by the protein known as RNA polymerase. Their findings are published in the March 16 issue of the journal Science.

"An RNA-dependent RNA polymerase ribozyme is the foundation of the entire RNA World hypothesis," Robertson said. "With that, you would have an RNA capable of making copies of itself; mutations or errors in some copies would result in variations that would be acted on by Darwinian natural selection, and the molecules would evolve into bigger and better ribozymes. That's what makes this structure so interesting."

Robertson and Scott determined the structure of a ribozyme that is not an entirely self-replicating RNA molecule, but it does carry out the fundamental reaction required of such a molecule--a "l
'"/>

Source:University of California - Santa Cruz


Page: 1 2

Related biology news :

1. Lack of enzyme turns fat cells into fat burners
2. Scientists find missing enzyme for tuberculosis iron scavenging pathway
3. Researchers report new pro-inflammatory role for anti-inflammatory enzyme
4. Purdue researchers use enzyme to clip DNA wires
5. Scientists take aim at virulent bacteria by decoding machinery of key control enzyme
6. VCU Massey Cancer Center study shows enzyme linked to spread of breast cancer cells
7. Targeting a key enzyme with gene therapy reversed course of Alzheimers disease in mouse models
8. UCLA researchers identify key enzyme linked to childhood blindness
9. K-State professors discover enzyme responsible for creation of a beetles hard shell
10. Smoking damages key regulatory enzyme in the lung
11. New discovery: If it werent for this enzyme, decomposing pesticide would take millennia
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: RNA enzyme structure offers glimpse into the origins life

(Date:4/1/2015)... 1, 2015  NXT-ID, Inc. (NASDAQ: NXTD ) ... on the growing mobile commerce market, announces the second ... is underway to early access pre-order customers. ... at retail outlets including Walmart, Target, AT&T, Dunkin, Donuts, ... was accepted at all outlets and very easy to ...
(Date:3/26/2015)... The Granite Club, Canada,s ... announced it has implemented a state-of-the-art access and security ... and staff, while restricting access to authorized users only. ... IMID Access system because it has the perfect combination ... in addition to unparalleled security," said James DiRenzo ...
(Date:3/23/2015)... 2015 SoundView Technology Group issues a new research ... ) Wocket smart wallet. SoundView was one of the selected user ... with the Wocket in multiple scenarios and outlets. ... other retailers, making both debit and credit card payments.  ... "If the company meets their plans in 2015, it would ...
Breaking Biology News(10 mins):NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4
... of Utah cardiologist proposes as a cause of heart disease ... Health (NIH) likes to seeand reward with one of its ... Ivor J. Benjamin, M.D., professor of internal medicine and biochemistry ... at the U of U School of Medicine, believes that ...
... episodes in the 8000-year history of grapevine cultivation led ... until now. Through biomolecular detective work, German researchers ... varieties in cultivation today. In the process, they have ... and more accurate evaluation of the results, potentially breaking ...
... The National Institute for Mathematical and Biological ... to introduce selected topics in optimal control and ... "Optimal Control and Optimization for Biologists" will be ... University of Tennessee, Knoxville (UTK), campus. The application ...
Cached Biology News:Groundbreaking model of heart disease rewarded with NIH Pioneer Award 2Groundbreaking model of heart disease rewarded with NIH Pioneer Award 3Genetic discovery could break wine industry bottleneck, accelerate grapevine breeding 2Genetic discovery could break wine industry bottleneck, accelerate grapevine breeding 3
(Date:5/5/2015)... , May 5, 2015 CytomX, a biotechnology ... today announced that Sean McCarthy , D. Phil., ... Antibody Day in New York ... McCarthy will present an overview of CytomX,s Probody pipeline, ... conjugate programs. About CytomX Therapeutics CytomX ...
(Date:5/5/2015)... WASHINGTON , May 5, 2015  Indianapolis-based ... adoption of its innovative line of products including ... solution for atraumatically accessing deep-seated brain abnormalities and ... have been completed at more than 50 institutions ... The technology has also been included in 12 ...
(Date:5/4/2015)... JSS Medical Research Inc., a Montreal based ... of Max Neeman International (MNI), with head office in ... Ahmedabad, Bangalore , Chennai ... regional office is located North Carolina, USA . ... equity investment transaction into JSS with Capital Croissance PME (CCPME), a ...
(Date:5/4/2015)... - Fluorinov Pharma (Fluorinov), a FACIT portfolio company, ... Roger J Garceau, to its Board of Directors. ... including corporate development and clinical strategy, his appointment ... expertise as Fluorinov transitions to clinical development.  ... pharmaceutical development experience to Fluorinov and most recently ...
Breaking Biology Technology:NICO Corporation Gains Market Expansion after Multiple Published Clinical Articles Support Access Technology for Deep Brain Lesions 2NICO Corporation Gains Market Expansion after Multiple Published Clinical Articles Support Access Technology for Deep Brain Lesions 3JSS Medical Canada widens its global presence across Asia/Pacific region 2JSS Medical Canada widens its global presence across Asia/Pacific region 3JSS Medical Canada widens its global presence across Asia/Pacific region 4Roger J Garceau joins Fluorinov board, adds clinical expertise to bromodomain program and oncology pipeline 2Roger J Garceau joins Fluorinov board, adds clinical expertise to bromodomain program and oncology pipeline 3
... 3, 2011 Vermillion, Inc. (NASDAQ: ... received a notice of allowance from the United States Patent ... of biomarkers that could be used in the diagnosis of ... of heart attack and stroke. The patent, entitled ...
... HOPKINTON, Mass., Nov. 3, 2011 Caliper Life Sciences, Inc. ... for the third quarter ended September 30, 2011.  Third quarter ... the same period in 2010.  Organic revenue, which excludes the ... over the third quarter of 2010 and 21% on a ...
... University of Technology (QUT) researchers have developed new ... water and aiding clean-up efforts following nuclear disasters. ... of how to clean up millions of tonnes ... safely store the concentrated waste. Professor Huai-Yong ...
Cached Biology Technology:Vermillion Receives Notice of Allowance for 5th Biomarker Patent Related to Peripheral Artery Disease 2Vermillion Receives Notice of Allowance for 5th Biomarker Patent Related to Peripheral Artery Disease 3Caliper Life Sciences Reports Third Quarter 2011 Results 2Caliper Life Sciences Reports Third Quarter 2011 Results 3Caliper Life Sciences Reports Third Quarter 2011 Results 4Caliper Life Sciences Reports Third Quarter 2011 Results 5Caliper Life Sciences Reports Third Quarter 2011 Results 6Caliper Life Sciences Reports Third Quarter 2011 Results 7Caliper Life Sciences Reports Third Quarter 2011 Results 8Caliper Life Sciences Reports Third Quarter 2011 Results 9Caliper Life Sciences Reports Third Quarter 2011 Results 10Caliper Life Sciences Reports Third Quarter 2011 Results 11Caliper Life Sciences Reports Third Quarter 2011 Results 12Caliper Life Sciences Reports Third Quarter 2011 Results 13Caliper Life Sciences Reports Third Quarter 2011 Results 14Caliper Life Sciences Reports Third Quarter 2011 Results 15Caliper Life Sciences Reports Third Quarter 2011 Results 16Caliper Life Sciences Reports Third Quarter 2011 Results 17Caliper Life Sciences Reports Third Quarter 2011 Results 18Caliper Life Sciences Reports Third Quarter 2011 Results 19Technology makes storing radioactive waste safer 2
... The Vibratome Company has joined forces with ... the Vibratome 411301 Tissue Chopper. This tissue ... sections of tissue for metabolic experiments and ... irregular specimens available at biopsy or from ...
... Antibody Capture Kit eliminates ... optimization steps typically required ... This kit enables the ... multiple antigens based on ...
Without sodium bicarbonate. Sterile, Cell culture tested...
... Custom Peptide Services offer a full ... your research needs. Services include: Peptide ... Peptide synthesis, purified product (70-95% ... (acetylation, amidation, biotinylation, fluorescein, myristylation, phosphorylation, and ...
Biology Products: