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'Punctuated' evolution in the human genome

es behind this "punctuated" duplicative activity may have been changes in transcriptional status or chromatin conformation.

"Other regions may show different temporal biases," explains Eichler. "The important implication here is that episodic bursts of activity challenge the concept of gradual clock-like changes during the course of genome evolution. Since duplications are important in the birth of new genes and large-scale chromosomal rearrangements, it may follow that these processes may have gone through similar episodes of activity followed by quiescence."


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Source:Cold Spring Harbor Laboratory


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