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Pulsating ultrasound enhances gene therapy for tumors

However, these types of tumors have responded to certain types of therapeutic genes.

"This procedure is hypothetically generic for enhancing delivery to all tissues," Dr. Frenkel said. "Previous studies by Dr. Li have shown that pulsed-HIFU increases the uptake of drugs. Now we've shown that it works for genes and we're making the case that there's a connection between the two."

Other methods currently being investigated for enhancing gene delivery, such as lasers and electric current, are limited to surface lesions or require needles to be inserted in the body. Pulsed-HIFU is non-invasive and can treat any area of the body accessible by ultrasound, the exceptions being the lungs and bones. Additional advantages of pulsed-HIFU include no scarring, limited blood loss and infections, reduced risk of other complications, shortened recovery time, significant reduction in costs and the potential for many procedures to be done on an outpatient basis.


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Source:Radiological Society of North America


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