Navigation Links
Pulsating ultrasound enhances gene therapy for tumors

High-intensity focused ultrasound emitted in short pulses is a promising, non-invasive procedure for enhancing gene delivery to cancerous cells without destroying healthy tissue, according to a study in the May issue of the journal Radiology.

High-intensity focused ultrasound (HIFU) is more powerful than standard ultrasound. HIFU can destroy tumors through long and continuous exposures that raise the temperature inside cancerous cells, effectively "cooking" them. Under a technique introduced by King C.P. Li, M.D., M.B.A., from the National Institutes of Health (NIH), short pulses of HIFU can be used to prevent exposed tissue from becoming too hot and damaged. Pulsed-HIFU instead renders tissues permeable and helps target them for taking up genes and other therapeutic substances injected into the body.

"Basically, we're using sound waves to open up the tissue by producing gaps between the cells, making it leakier and more prone to taking up various genes, agents and compounds," said Victor Frenkel, Ph.D., a staff scientist for the diagnostic radiology department at the NIH Clinical Center in Bethesda, Md.

Working with lead authors Kristin M. Dittmar, M.D., and Jianwu Xie, M.D., the researchers used pulsed-HIFU on tumors in mice, then immediately injected an easily measurable reporter gene into the vein in their tails. The reporter gene in this study--a fluorescent-green protein found in deep-sea invertebrates--was visible in all sections of the tumors exposed to pulsed-HIFU. Tumors not targeted with pulsed-HIFU showed negligible signs of the gene.

An analysis showed reporter gene levels to be nine times higher in tumors treated with pulsed-HIFU compared with tumors left unexposed.

Researchers were especially encouraged by the results because the type of cancer treated in the study--squamous cell carcinoma, found in head and neck tumors--is one of the least permeable cancers and does not respond well to chemotherapy or radiation.
'"/>

Source:Radiological Society of North America


Page: 1 2

Related biology news :

1. Penn researchers study the use of ultrasound for treatment of cancer
2. 3D ultrasound device poised to advance minimally invasive surgery
3. 3-D ultrasound scanner could guide robotic surgeries
4. 3-D ultrasound identifies women at risk for impending preterm birth
5. Elevated temperature enhances success of viral cancer therapy
6. NYU algorithm enhances ability to detect cancer genes
7. Proteasome activator enhances survival of Huntingtons disease neuronal model cells
8. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
9. Columbia research lifts major hurdle to gene therapy for cancer
10. Combination therapy boosts effectiveness of telomere-directed cancer cell death
11. Gene therapy converts dead bone graft to new, living tissue
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Pulsating ultrasound enhances gene therapy for tumors

(Date:8/12/2015)... , Aug. 12, 2015   MedNet Solutions ... the entire spectrum of clinical research, is proud to ... the company,s comprehensive SaaS-based eClinical technology platform, has led ... the first two quarters of 2015.   Q2 2015 ... largest quarters measured by contract value sold in the ...
(Date:8/12/2015)... 2015  New research unveiled at Black Hat ... to steal users, fingerprints. Information released today by ... scanners on mobile devices, making the security of ... on mobile devices, HYPR Corp. recently released a ... systems with strong cryptographic security. More information on ...
(Date:8/11/2015)... Today, ZUK announced its Android smartphone Z1, featuring FPC,s touch ... 2015 that relate to sales of FPC1155 for this smartphone model ... for 2015. Jörgen Lantto, CEO of FPC, comments: " ... manufacturer in China and we are proud ... for Z1 , its first ...
Breaking Biology News(10 mins):MedNet Solutions Experiences Explosive Corporate Growth 2HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 2HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 3FPC's Touch Fingerprint Sensor FPC1155 in ZUK's Smartphone Z1 2
... Los Angeles, Calif., May 22, 2011Some men of African ... cancer, according to research conducted at the Keck School of ... genome-wide association study, published in the journal Nature Genetics ... prostate cancer in men of African descent, who tend to ...
... the development of drug resistance in breast cancer which could ... the journal Nature Medicine . In a mouse ... genetic techniques caused tumours to shrink. The scientists are now ... Breast cancer is the most common cancer in the ...
... NEW ORLEANS, LA May 22, 2011 -- The ... role in the development of Parkinson,s disease according to ... the American Society for Microbiology. "Infection of late ... Helicobacter pylori results in development of Parkinson,s ...
Cached Biology News:USC research determines apparent genetic link to prostate cancer in African-American men 2Scientists find new drug target in breast cancer 2Ulcer bacteria may contribute to development of Parkinson's disease 2
(Date:9/3/2015)... SAN DIEGO , Sept. 3, 2015 /PRNewswire/ ... factors, and a recent spinout of Stemedica Cell ... Thomas H. Silberg as CEO of StemProtein. ... technology for producing and preserving Stem Cell Factors ... is a seasoned professional in the pharmaceutical and biopharmaceutical ...
(Date:9/2/2015)... , Sept. 2, 2015 Axovant Sciences Ltd. ... treatment of dementia, today announced upcoming presentations at three investor ... at the Baird 2015 Healthcare Conference in New ... , Thursday, September 10 at 2:00 PM at the BioCentury ... the Millennium Broadway Hotel & Conference Center , Thursday, ...
(Date:9/2/2015)... ... September 02, 2015 , ... The wet form of ... special anti-vascular endothelial growth factor agents given by injection into the eye. Dry ... a scientific protocol for the many millions diagnosed with it. AMD usually starts ...
(Date:9/2/2015)... ... September 02, 2015 , ... ... botanical and plant-derived compounds. BCC Research reveals in its new report that ... this market defines the category and generates the most market demand. , ...
Breaking Biology Technology:StemProtein Names Thomas H. Silberg As CEO, To Focus On Stem Cell Secreted Proteins Addresing A Variety Of Health And Beauty Related Needs 2StemProtein Names Thomas H. Silberg As CEO, To Focus On Stem Cell Secreted Proteins Addresing A Variety Of Health And Beauty Related Needs 3Axovant Sciences To Present At Upcoming Investor Conferences 2Axovant Sciences To Present At Upcoming Investor Conferences 3StemCell GeneticMed Announces That It Has Started Stem Cell Treatments for Age Related Dry Macular Degeneration (AMG) 2Plant-derived Compounds Poised to Assume Greater Role in Global Drug Markets, According to BCC Research 2Plant-derived Compounds Poised to Assume Greater Role in Global Drug Markets, According to BCC Research 3
... Inc. announced today Winchester Hospital ... of APIs suite of labor resource management solutions ... include Payrollmation time and attendance, ActiveStaffer staff scheduling, ... , ,The hospital is adopting the applications in ...
... MILWAUKEE - Merge eFilm , a global ... the release of eFilm Workstation 1.9 and ... PACS for 10 imaging centers. , ,eFilm Workstation ... the ability to view and manipulate digital diagnostic ...
... long-standing riddle of whether the Earth's ice ages occurred simultaneously ... the glacial deposits found in the high desert east of ... effects of cosmic rays on minerals found in boulders carried ... of scientists from the University of Wisconsin-Madison has demonstrated that ...
Cached Biology Technology:Glacial records depict ice age climate in synch worldwide 2Glacial records depict ice age climate in synch worldwide 3
Sigmas E-TOXATE (Limulus Amebocyte Lysate) test kits are intended for the detection and semiquantitation of endotoxins for research purposes. sensitivity 0.05-0.1 EU/mL...
... This sealed isolation chamber provides a ... repackaging sterile pharmaceuticals, in accord with ... Class 100 (ISO 5) cleanliness conditions ... antechamber, IV rod and tilt-up front ...
... Note: Protein determined by Biuret. ... M (NH 4 ) 2 ... Preparation Note: Affinity purified • ... • Additives: MgCl 2 1 ...
Ideal for chemical processing that requires downward flow of exhaust fumes. Powderful 1200 CFM blower draws fumes into sub-surface bonded charcoal filter for safe removal of organic vapors (final HEP...
Biology Products: