Navigation Links
Pulsating ultrasound enhances gene therapy for tumors

High-intensity focused ultrasound emitted in short pulses is a promising, non-invasive procedure for enhancing gene delivery to cancerous cells without destroying healthy tissue, according to a study in the May issue of the journal Radiology.

High-intensity focused ultrasound (HIFU) is more powerful than standard ultrasound. HIFU can destroy tumors through long and continuous exposures that raise the temperature inside cancerous cells, effectively "cooking" them. Under a technique introduced by King C.P. Li, M.D., M.B.A., from the National Institutes of Health (NIH), short pulses of HIFU can be used to prevent exposed tissue from becoming too hot and damaged. Pulsed-HIFU instead renders tissues permeable and helps target them for taking up genes and other therapeutic substances injected into the body.

"Basically, we're using sound waves to open up the tissue by producing gaps between the cells, making it leakier and more prone to taking up various genes, agents and compounds," said Victor Frenkel, Ph.D., a staff scientist for the diagnostic radiology department at the NIH Clinical Center in Bethesda, Md.

Working with lead authors Kristin M. Dittmar, M.D., and Jianwu Xie, M.D., the researchers used pulsed-HIFU on tumors in mice, then immediately injected an easily measurable reporter gene into the vein in their tails. The reporter gene in this study--a fluorescent-green protein found in deep-sea invertebrates--was visible in all sections of the tumors exposed to pulsed-HIFU. Tumors not targeted with pulsed-HIFU showed negligible signs of the gene.

An analysis showed reporter gene levels to be nine times higher in tumors treated with pulsed-HIFU compared with tumors left unexposed.

Researchers were especially encouraged by the results because the type of cancer treated in the study--squamous cell carcinoma, found in head and neck tumors--is one of the least permeable cancers and does not respond well to chemotherapy or radiation.
'"/>

Source:Radiological Society of North America


Page: 1 2

Related biology news :

1. Penn researchers study the use of ultrasound for treatment of cancer
2. 3D ultrasound device poised to advance minimally invasive surgery
3. 3-D ultrasound scanner could guide robotic surgeries
4. 3-D ultrasound identifies women at risk for impending preterm birth
5. Elevated temperature enhances success of viral cancer therapy
6. NYU algorithm enhances ability to detect cancer genes
7. Proteasome activator enhances survival of Huntingtons disease neuronal model cells
8. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
9. Columbia research lifts major hurdle to gene therapy for cancer
10. Combination therapy boosts effectiveness of telomere-directed cancer cell death
11. Gene therapy converts dead bone graft to new, living tissue
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Pulsating ultrasound enhances gene therapy for tumors

(Date:12/10/2014)... , Dec. 9, 2014  Wake Forest Baptist Medical Center ... for its School of Medicine. Funding for this $50 ... campaign that will be publicly launched next summer. ... in the former 60 series R.J. Reynolds Tobacco Company ... Construction will begin immediately with plans to be ready ...
(Date:12/5/2014)... MOUNTAIN VIEW, Calif. , Dec. 4, 2014 ... and safety has boosted investments in new testing ... products has also given rise to a range ... driven by the requirements of Generation Y, which ... digital technologies. As a result, product development strategies ...
(Date:12/3/2014)... GLENDALE, Ariz. , Dec. 2, 2014 ... biometric hand readers, Inception Technologies is pleased to announce ... it easier for customers to collect the workforce data ... the problems that have been left by existing readers. ... to user interface, connectivity and modern technology. Older models ...
Breaking Biology News(10 mins):Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4Inception Technologies to Release New Biometric Reader 2
... in the rugged Marquesas Islands (French Polynesia) have increased the ... research and collecting in conjunction with the Vascular Flora ... Polynesie franaise projects have yielded 62 new species of ... 360, of which 18 are newly described and illustrated in ...
... available in German . They live their lives upside ... position, sloths spend most of their lives hanging in trees upside ... Very slowly. But why are sloths so ,lazy,? And how has ... in the course of evolution? Zoologists of the Friedrich Schiller University ...
... to be genes that, when mutated, change healthy cells into ... of the University of Southern California (USC) have proven that ... paving the way to a safer and more practical approach ... cell therapy. "The reality may be more complicated than ...
Cached Biology News:Marquesas Islands in French Polynesia yield 18 new species of rare ferns and flowering plants 2The decoding of slowness 2USC research: Cancer cells and stem cells share same origin 2
(Date:12/22/2014)... RepliCel Life Sciences Inc. (OTCQB: REPCF) (TSX.V: RP), a ... of autologous cell therapies, announced today the publication of ... conjunction with co-authors from Kyoto University and the University ... clinical research using dermal sheath cup (DSC) cells to ... paper entitled " Hair Follicle Dermal Stem Cells Regenerate ...
(Date:12/22/2014)... (PRWEB) December 22, 2014 ... peer-reviewed publication of original research, reviews and editorials ... and clinical practice, today published a provocative article ... the development, progression and potential treatment of prostate ... endocrinology research and proposes the possibility that there ...
(Date:12/19/2014)... December 19, 2014 Charm Sciences is ... for the Detection of Aflatoxin M1 in raw commingled ... independent third party validation. The peer reviewed report of ... the Institute for Agricultural and Fisheries Research (ILVO-T&V) has ... , Aflatoxin B1, the most toxic aflatoxin and a ...
(Date:12/19/2014)... 19, 2014 Bina Technologies, Inc. (Bina, ... they have been acquired by Roche (SIX: RO, ROG; ... held company that provides a big data platform for ... data for the academic and translational research markets.  Bina ... will continue to focus on development of their innovative ...
Breaking Biology Technology:Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 2Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 3Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 4Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 5Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 2Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 3Prostate Cancer Experts Dissect the Role of Follicle-stimulating Hormone in the Development, Progression and Potential Treatment of Prostate Cancer 4Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... - Vasogen Inc.,(NASDAQ: VSGN ; TSX:VAS) today reported the ... August 31, 2008. All dollar amounts referenced,herein are in ... 2008, our cash and cash equivalents totaled $9.8 million,compared ... net loss for the third quarter of 2008 was ...
... 15 Quincy Bioscience (Madison, WI),announces that ... of the jellyfish protein apoaequorin, has displayed ... subjects tested. The Prevagen,Memory Study included 56 ... mg/day). The findings suggest that supplementation with,apoaequorin, ...
... 08/07 ... millions sales change millions sales change, ... 16 Other EU countries (2) 7.1 24 17 8.6 ... 24 1.8 5 18, SLIT ...
Cached Biology Technology:Vasogen Announces Third Quarter 2008 Results 2Vasogen Announces Third Quarter 2008 Results 3Vasogen Announces Third Quarter 2008 Results 4Vasogen Announces Third Quarter 2008 Results 5Vasogen Announces Third Quarter 2008 Results 6Vasogen Announces Third Quarter 2008 Results 7Vasogen Announces Third Quarter 2008 Results 8Vasogen Announces Third Quarter 2008 Results 9Vasogen Announces Third Quarter 2008 Results 10Jellyfish Protein Shows Potential to Help With Memory 2Jellyfish Protein Shows Potential to Help With Memory 3Stallergenes: Sales at end September 2008: + 17% - 2008 Sales Guidance Revised Upwards: + 14% 2Stallergenes: Sales at end September 2008: + 17% - 2008 Sales Guidance Revised Upwards: + 14% 3
... Partek Genomics Solution is a comprehensive ... data visualization specifically designed to reliably ... for high-dimensional genomic studies containing thousands ... fast, memory efficient and will analyze ...
Kit contains: Bio-Rad Amplification Reagent, 2x Amplification Diluent, Streptavidin-HRP, Blocking Reagent, and Phosphate Buffered Saline....
These macrocarriers are for the biolistic PDS-1000 He and Hepta systems. Supplied as 500 macrocarriers....
Intestinal Epithelium Differentiation Environment...
Biology Products: