Navigation Links
Prozac's target revealed

Researchers at Cold Spring Harbor Laboratory on Long Island have identified which among several different kinds of cells in the brain is the chief target of the widely prescribed antidepressant Prozac. This discovery might enable a new generation of more specific treatments for depression, with fewer side effects, to be developed.

The findings also lay the foundation for many studies of the factors that control how, when, and where new neurons are generated from stem cells in the brain. Such work could eventually lead to cell replacement therapies for neurodegenerative and other brain disorders including Alzheimer's and Parkinson's disease.

It has been known for some years that Prozac (fluoxetine) is likely to relieve the symptoms of depression by somehow causing more neurons to be present in a particular region of the brain (the "dentate gyrus"). But the origins of these neurons, and how Prozac promotes their existence, have been a mystery until now.

By profiling the telltale marker proteins produced by different kinds of cells in the brains of adult mice, the researchers first defined discrete steps in the complex process, called neurogenesis, that converts unspecialized stem cells into mature, specialized neurons.

Next, knowing that Prozac treatment somehow increases the number of neurons in the brain, the researchers tested which step in the neurogenesis pathway might be stimulated by Prozac. They found that Prozac treatment specifically stimulates the generation of a kind of cells they dubbed "amplifying neural progenitors" or ANPs--the second step in the neurogenesis pathway from stem cells to mature neurons. (Illustration available on request)

The study is published in the published in the Proceedings of the National Academy of Sciences (advance on-line this week, in print on May 23). It was led by Grigori Enikolopov and spearheaded by postdoctoral fellow Juan Manuel Encinas.

To address the controversy surroundin
'"/>

Source:Cold Spring Harbor Laboratory


Page: 1 2

Related biology news :

1. New binding target for oncogenic viral protein
2. Ancient olfaction protein is shared by many bugs, offering new pest control target
3. A bacterial genome reveals new targets to combat infectious disease
4. Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
5. Researchers identify target for cancer drugs
6. Study reveals candidate targets for anti-retroviral therapeutics
7. MUHC researchers make cancer target breakthrough
8. Future diabetes drugs may target new protein interaction
9. Smart drug targets deadly brain cancer
10. NHGRI targets 12 more organisms for genome sequencing
11. While on trail of dioxin, scientists pinpoint cancer target of green tea
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Prozac target revealed

(Date:11/4/2014)... PA) – Temple University School of Medicine announced ... winner, an initiative funded by the Bill & ... Professor of Obstetrics, Gynecology and Reproductive Sciences; and ... Temple University School of Medicine will pursue an ... "Maternal Blood Biomarkers to Assess Fetal Neurodevelopment.", Grand ...
(Date:11/4/2014)... A newly published research study examining only marketing ... of fast food restaurants has found that the ... disproportionately exposed to such marketing tactics. , Authored ... her colleagues, the study is the first to ... interior and exterior of fast food restaurants and ...
(Date:11/4/2014)... 2014) – A majority of Madagascar,s 101 species of ... serious consequences for the rainforests they call home. A ... impacts lemurs can have on rainforest tree populations, which ... have on the region,s rich biodiversity. , A large ... by lemurs. Lemurs in turn disperse the seeds ...
Breaking Biology News(10 mins):Temple University School of Medicine receives Grand Challenges Explorations grant 2Fast food marketing for children disproportionately affects certain communities 2Fast food marketing for children disproportionately affects certain communities 3Gardeners of Madagascar rainforest at risk 2Gardeners of Madagascar rainforest at risk 3
... National Institute of Standards and Technology (NIST) announced today ... million to three universities to provide cost-shared support for ... projects were chosen from 93 applicants in a special ... $10.98 million to the University of ...
... vacancy sign is on, but the lowlifes who check ... of Florida and the University of New Mexico have ... bacteria in a manner the scientists liken to "roach ... to new coatings that will disinfect common surfaces, combat ...
... CANovember 24, 2008Researchers at The Scripps Research Institute have figured ... long and twisted tangles of DNA within a cell,s nucleus ... direct the synthesis of proteins, which have many specific functions ... published in the November 23, 2008 online issue of ...
Cached Biology News:NIST awards $24M in grants for new research facilities 2NIST awards $24M in grants for new research facilities 3NIST awards $24M in grants for new research facilities 4NIST awards $24M in grants for new research facilities 5Scientists build 'roach motel' for nasty bugs of the bacterial variety 2Scripps Research scientists shed light on how DNA is unwound so that its code can be read 2Scripps Research scientists shed light on how DNA is unwound so that its code can be read 3
(Date:11/22/2014)... 2014 Prominent academics, leaders of ... on December 3rd at Genetic Rx, a networking ... will take place at the Joseph B. Martin ... discuss the present and future of genetic medicines—including ... gene editing—as well as the treatment of patients ...
(Date:11/22/2014)... (PRWEB) November 22, 2014 The ... Analytical, Preparative), by Material (Metal, Glass, Plastic), by ... TLC, SFC] - Forecast to 2018” analyses and ... challenges in North America, Europe, Asia, and Rest ... tables and 15 figures spread through 135 pages ...
(Date:11/21/2014)... , Todd Martensen se une ... Rodríguez es elegid vicepresidente senior de desarrollo empresarial y responsable ... para comenzar de forma rápida la comercialización de su sistema ... Europa   , KLOX Technologies Inc. ... nombramientos: Todd Martensen ha sido contratado ...
(Date:11/21/2014)... Author Matthew J. Pallamary’s second short story ... published as a tribute to his mentor Ray ... Story” category of the 2014 USA Best Book ... USA Book News, said this year’s contest yielded over ... & Schuster, Penguin, John Wiley & Sons, Houghton Mifflin ...
Breaking Biology Technology:Pioneering Academics and Key Industry Leaders to Discuss Rare Diseases and the Emergence of New Genetic Medicines at Genetic Rx on December 3rd 2Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 2Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 3Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 4Chiral Chromatography Columns Market worth $87.8 Million by 2018 - New Research Report by MarketsandMarkets 5KLOX Technologies anuncia sus nombramientos ejecutivos 2KLOX Technologies anuncia sus nombramientos ejecutivos 3KLOX Technologies anuncia sus nombramientos ejecutivos 4KLOX Technologies anuncia sus nombramientos ejecutivos 5Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 2Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 3Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 4
... GPRO ) announced today that the Company will present ... 1, 2008 at,approximately 4:20 p.m. Eastern Time. The presentation ... through a link on the investors section of,Gen-Probe,s website ... 30 days following the event., About Gen-Probe, ...
... 24 /PRNewswire/ ETEX Corporation, an advanced,biomaterials company, ... a supply,agreement with AlloSource., (Logo: ... ETEX with Demineralized Bone Matrix (DBM),powder to ... setting,calcium phosphate to form EquivaBone(TM)., This ...
... Trubion Pharmaceuticals,Inc. (Nasdaq: TRBN ), today announced that executives ... in April and,May:, -- April 30: Morgan ... Ritz-Carlton, 455 Grand Bay Drive in Key Biscayne, FL. Dr. Peter ... to present at 9:50 a.m. EDT. The ...
Cached Biology Technology:Gen-Probe to Webcast Presentation at Morgan Stanley Global Healthcare Unplugged Conference 2ETEX Announces Supply Agreement with AlloSource 2Trubion Announces Presentations at April/May Investor Conferences 2
... screen, without Camera • ... mega pixel resolution. It is computer free for ... from large 5.6" TFT color liquid crystal display ... capture image for fluorescent gels, colorimetric gels, auto ...
... The binding specificity and signaling of the ... to be modified by alternative splicing--which has ... SpliceArrays you can perform a classical expression ... the different alternatively spliced forms of the ...
Mouse monoclonal antibody raised against a full length recombinant CSNK2A2. NCBI Entrez Gene ID = CSNK2A2...
... Apoptosis is an evolutionarily conserved form of ... process. The central component of this ... called caspases. These enzymes participate in ... in response to pro-apoptotic signals and result ...
Biology Products: