Navigation Links
Proteins stop blood-vessel and tumor growth in mice

Researchers at National Jewish Medical and Research Center report in the March issue of Cancer Research that a pair of promising proteins, known as fibulins 3 and 5, slow the growth of cancer tumors in mice by preventing blood vessels from sprouting. The proteins are promising candidates for use in cancer therapy.

"Healthy humans produce fibulin proteins, which regulate cell proliferation, migration and invasion. In the past, we have seen that they are depleted in numerous metastatic cancers, and that they inhibit the formation of new blood vessels in cell culture," said William Schiemann, Ph.D., Assistant Professor in the Program in Cell Biology at National Jewish. "Our current findings show that fibulins can inhibit both tumor growth and blood-vessel formation in mice."

Tumors need nutrients and oxygen supplied by blood vessels in order to grow. They also use blood vessels to spread to other parts of the body. This process, known as metastasis, is the most lethal stage of cancer and the leading cause of cancer-related death. Fighting cancer by starving tumors of life-giving blood vessels has generated great interest in recent years.

In their most recent experiments, Dr. Schiemann and his colleagues injected a biological material, called Matrigel, into mice. The Matrigel contained a growth factor that promotes blood-vessel growth and either a control substance or fibulin 3 or fibulin 5. After seven days, researchers found that the Matrigel plugs containing either fibulin had about half as many blood vessels as did the control plugs.

The researchers then injected fibrosarcoma tumor cells into mice. The tumor cells were genetically engineered to produce either fibulin 3 or fibulin 5. Three weeks after the cells were implanted, developing tumors that produced the fibulins were approximately 24 percent to 45 percent smaller than the control tumors.

"We are thrilled that the fibulins continue to show promise as we move into animal
'"/>

Source:National Jewish Medical and Research Center


Page: 1 2

Related biology news :

1. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
2. Hirsute Or Hairless? Two Proteins May Spell The Difference
3. Proteins spur diabetic mice models to grow blood vessels, nerves
4. Parallel evolution: Proteins do it, too
5. Proteins as parents
6. Proteins anchor memories in our brain
7. Proteins may behave differently in natural environments
8. Proteins necessary for brain development found to be critical for long-term memory
9. Proteins may predict lung transplant rejection
10. Proteins important in Alzheimers, Parkinsons disease travel in the slow lane
11. Mouse brain tumors mimic those in human genetic disorder
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Proteins stop blood vessel and tumor growth mice

(Date:5/23/2013)... DNA around nucleosomes in the cell nucleus makes ... Ludwig-Maximilians-Universitaet (LMU) in Munich now describes a mechanism ... from nucleosomes for transcription. , In higher organisms ... nucleus, wrapped around disk-shaped particles called nucleosomes, each ... proteins and accommodating two loops of DNA. Packed ...
(Date:5/23/2013)... medics have succeeded in treating cerebral palsy with autologous ... damage, a 2.5 year old boy had been in ... survival. Just two months after treatment with the cord ... the following months, the child learned to speak simple ... from a Korean study, dispel the long-held doubts about ...
(Date:5/23/2013)... pathogens are growing increasingly resistant to the conventional antibiotics ... scientists has synthesized a potent new class of compounds ... , Writing online in the Journal of the ... of Wisconsin-Madison chemistry Professor Helen Blackwell describes agents that ... Staphylococcus aureus , a bacterium at the root of ...
Breaking Biology News(10 mins):Biochemistry: Unspooling DNA from nucleosomal disks 2First successful treatment of pediatric cerebral palsy with autologous cord blood 2University of Wisconsin chemists find new compounds to curb staph infection 2
... like Celecoxib have come under scrutiny lately due to ... fruit fly and rat models, researchers reveal another adverse ... interestingly, this effect is independent of the COX-2 enzyme. ... doses on the heart rate of Drosophila, a good ...
... History of Marine Animal Population , Edited by ... available on: http://shop.earthscan.co.uk/ProductDetails/mcs/productID/821 , Violent confrontations ... feature of the intense hunt for sponges on Floridas ... were the sponges themselves. Human harvesters not only depleted ...
... Society (ACS) News Service Weekly PressPac with news from ACS ... individual journal or the American Chemical Society as the source ... EXCEPT ARTICLE #5, which is embargoed for 9 A. M., ... IMMEDIATE RELEASE Seagull blood shows promise ...
Cached Biology News:Oceans Past: A Guide to Oceans Future 2Oceans Past: A Guide to Oceans Future 3Oceans Past: A Guide to Oceans Future 4Oceans Past: A Guide to Oceans Future 5Oceans Past: A Guide to Oceans Future 6American Chemical Society's weekly PressPac -- Jan. 9, 2008 2American Chemical Society's weekly PressPac -- Jan. 9, 2008 3American Chemical Society's weekly PressPac -- Jan. 9, 2008 4American Chemical Society's weekly PressPac -- Jan. 9, 2008 5American Chemical Society's weekly PressPac -- Jan. 9, 2008 6American Chemical Society's weekly PressPac -- Jan. 9, 2008 7American Chemical Society's weekly PressPac -- Jan. 9, 2008 8American Chemical Society's weekly PressPac -- Jan. 9, 2008 9
(Date:5/23/2013)... PI’s new LPS-24 positioners are ... mm travel range with closed-loop sensor resolution up ... these new positioners the ideal choice for high ... version is also available. , More Information: ... be found at: , http://www.physikinstrumente.com/en/products/prdetail.php?sortnr=1000745&prw-lps24 , ...
(Date:5/23/2013)... 23, 2013  Saddleback Memorial Medical Center in ... first hospital on the West Coast to perform a ... option provides women with a state-of-the-art, minimally invasive approach ... Winter , M.D., a highly regarded ... director of minimally invasive surgery at Saddleback Memorial, led ...
(Date:5/23/2013)... EXTON, Pa. , May 23, 2013 /PRNewswire/ ... leading research and advisory firms for specialized biopharmaceutical ... gastroenterologists, hepatologists, and infectious disease specialists reported that ... warehousing patients (e.g., intentionally delaying treatment) in anticipation ... physicians than six months ago, when only 6 ...
(Date:5/23/2013)... 23, 2013 Z Trim Holdings, Inc. (OTC ... a variety of industries, announced that Chef ... at this year,s National Restaurant Association ("NRA") NRA Show, ... of the Research Chefs Association.  Chef Ryan spoke on ... the Bad and the Ugly," joining four other prestigious ...
Breaking Biology Technology:Precision Positioning System Uses Miniaturezed Piezo Linear Motor: LPS-24 Linear Stage by PI 2Saddleback Memorial Surgeon First on the West Coast to Perform Single-Site Robotic Hysterectomy 2Saddleback Memorial Surgeon First on the West Coast to Perform Single-Site Robotic Hysterectomy 3The Majority of Physicians that Treat Hepatitis C Virus (HCV) Have Begun "Warehousing" and Preparing Their HCV Patients for the Next Generation of HCV Treatments 2The Majority of Physicians that Treat Hepatitis C Virus (HCV) Have Begun "Warehousing" and Preparing Their HCV Patients for the Next Generation of HCV Treatments 3Z Trim's Chef Erin Ryan sits on Expert Panel at NRA Show 2Z Trim's Chef Erin Ryan sits on Expert Panel at NRA Show 3
... PCR cloning with pcmv-script PCR cloning kit , ... Quinn,Lu ,Stratagene Cloning Systems, Inc. , , Stratagene ... cloning,strategy by introducing a new vector for high-efficiency cloning ... PCR,cloning kit uses a ...
... transfection reagent: A proven choice , ... transfection reagent offers,improved, consistent ... in,suspension. In this article, we summarize the results ... reagent. Optimizing transfection,conditions is a critical, preliminary step ...
... software aids image acquisition and processing , Michelle Cayouette *Michael Steege * ... Eagle Eyes Still Video System shown with Darkroom ... Stratagenes new Eagle Sight software version 3.0 allows researchers , ... information from stained , nucleic acids ...
Cached Biology Technology:Mammalian Expression Vector for Efficient Cloning of PCR Fragments 2Mammalian Expression Vector for Efficient Cloning of PCR Fragments 3Mammalian Expression Vector for Efficient Cloning of PCR Fragments 4Versatile Transfection Reagent Offers Low Toxicity and Consistent,Performance 2Versatile Transfection Reagent Offers Low Toxicity and Consistent,Performance 3Versatile Transfection Reagent Offers Low Toxicity and Consistent,Performance 4Versatile Transfection Reagent Offers Low Toxicity and Consistent,Performance 5Versatile Transfection Reagent Offers Low Toxicity and Consistent,Performance 6Versatile Transfection Reagent Offers Low Toxicity and Consistent,Performance 7Keys to Successful Densitometry 2Keys to Successful Densitometry 3Keys to Successful Densitometry 4Keys to Successful Densitometry 5Keys to Successful Densitometry 6
Microlite 1+ 1x12 Strip assembled, flat bottom; the ideal vessel for low signal luminescent reactions, offering medium binding with enhanced dynamic range, extra high reflectivity and minimal cross t...
Immulon 4 HBX 1x12 Strip, flat bottom; high binding extra surface with special resin and irradiation, offers maximum protein uptake....
... regulator and pressurized syringe holder for any researcher ... flow rate Microinjecting Fine microliter delivery ... added to any new or existing perfusion rig ... homemade. Connect to house air or a compressor ...
...
Biology Products: