Navigation Links
Proteins spur diabetic mice models to grow blood vessels, nerves

University of Utah researchers have taken a potentially powerful new therapy for treating diabetes, peripheral vascular disease, and other illnesses out of the test tube and into animals by demonstrating it restores nerve and blood vessel growth in mice.

The research has particularly important implications for the estimated 21 million Americans with diabetes, a disease that damages both nerves and blood vessels.

The therapy involves netrins, a family of proteins that promotes nerve development. In a study to be published this week in the journal Science Express, the Utah researchers and colleagues from other universities showed netrins not only accelerated blood vessel growth in ischemic mice (those with constricted blood flow) but they also restored blood vessel and nerve growth in diabetic mice. Dean Y. Li, M.D., Ph.D., a cardiologist and associate professor of internal medicine at the University's School of Medicine, is the study's corresponding author.

"We now have a (growth) factor that attracts both blood vessels and nerves--that's why it's unique for diabetes," Li said. "This demonstrates that netrins are critical for development and may be important as a new therapy."

Li and fellow researchers from the University of Utah and Stanford already had shown Netrin-1, a member of the netrins family, promotes blood vessel growth in laboratory cultures. But, until now, it had not been demonstrated that netrins work in animals.

The researchers tested netrins and vascular endothelial growth factor (VEGF), a gene-based therapy in Phase 2 clinical trials, in mice. They used the same method to inject netrins and VEGF. In the mice whose blood circulation was decreased by peripheral vascular disease, the researchers found netrins and VEGF promoted blood vessel growth equally well. But in the diabetic mice, netrins proved markedly better at promoting blood vessel and nerve growth than VEGF, according to Li.

Already in Phase 2
'"/>

Source:University of Utah Health Sciences Center


Page: 1 2

Related biology news :

1. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
2. Hirsute Or Hairless? Two Proteins May Spell The Difference
3. Proteins stop blood-vessel and tumor growth in mice
4. Parallel evolution: Proteins do it, too
5. Proteins as parents
6. Proteins anchor memories in our brain
7. Proteins may behave differently in natural environments
8. Proteins necessary for brain development found to be critical for long-term memory
9. Proteins may predict lung transplant rejection
10. Proteins important in Alzheimers, Parkinsons disease travel in the slow lane
11. New cell transplantation technique restores insulin production in diabetics
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Proteins spur diabetic mice models grow blood vessels nerves

(Date:6/17/2015)... June 17, 2015  Crossmatch™, a leading provider ... its U.are.U ® 4500 fingerprint readers have ... Eateries, Inc., a San Jose, CA ... increase security, improve accountability and reduce fraud at ... non-repudiable identity confirmation for employee sign in and ...
(Date:6/16/2015)... Fingerprint Cards has received an order ... company,s portfolio from one of its module partners in ... place during the third quarter 2015. The sensors will be ... Jörgen Lantto, CEO of FPC, comments: " This ... interest from smartphone OEMs in integrating touch fingerprint sensors in ...
(Date:6/15/2015)... YORK , June 15, 2015 ... today from Telstra reveals the majority of US consumers using ... them via biometrics, such as fingerprint and voiceprint, instead of ... According to Telstra,s " Mobile Identity   - ... " report, with smartphones now the primary channel used ...
Breaking Biology News(10 mins):Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 2Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 3FPC Receives Order for Touch Fingerprint Sensors of 375 MSEK 2One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 2One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 3One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 4
... SUNRISE, Fla. , July 8, 2013 /PRNewswire-iReach/ -- Jade ... the nation,s top plastic surgery and wellness centers, has just ... to the Tickle Lipo procedure. In addition, Tickle Lipo has ... decided to extend its special pricing for the procedure. ...
... new four-year, $1.58 million grant from the National Institute ... Western Reserve University School of Dental Medicine researcher to ... The grant will support a study by Yiping ... oral bacteria, Fusobacterium , and several of its ...
... Increased levels of carbon dioxide (CO2) have helped boost ... past 30 years through a process called CO2 fertilisation, ... observations, CSIRO, in collaboration with the Australian National University ... 11 per cent increase in foliage cover from 1982-2010 ...
Cached Biology News:Strax Rejuvenation Adds New Page to Website Devoted to Tickle Lipo Procedure 2CWRU dental researcher's NIDCR grant targets oral bacteria and fetal death link 2Deserts 'greening' from rising CO2 2
(Date:7/6/2015)... July 6, 2015  Viveve Medical, Inc. ("Viveve") (OTCQB: VIVMF), a ... Scheller , Viveve,s Chief Executive Officer, and Scott Durbin ... on July 9, 2015. , , , DATE:    ... , , , TIME:     , , , 12:15 ... , , http://tinyurl.com/viveve   , ...
(Date:7/3/2015)... 3, 2015 ... osoitteessa  http://www.openinnovationinscience.at Wienissä pidettävään ... Science" -jatkokoulutusohjelmaan 22.7.2015 asti.  ... tekemän, kansainvälisiä tutkijoita ja tiedemiehiä ... suurinta haastetta ovat kannustimien puute ...
(Date:7/3/2015)... July 3, 2015  Pomerantz LLP announces that a ... Inc. ("Puma" or the "Company")(NYSE: PBYI ) and ... United States District Court, Central District of ... behalf of a class consisting of all persons or ... and May 13, 2015 inclusive (the "Class Period").  This ...
(Date:7/2/2015)... 2015 Amici Procurement Migrates to ... Amici Procurement has chosen Microsoft Cloud Solution Provider ... Office 365.      (Logo: http://photos.prnewswire.com/prnh/20121126/579634) , ... companies in the bio-tech sector with a unique procurement ... cycle to help them obtain best value. Its IT ...
Breaking Biology Technology:Viveve to Webcast Live at VirtualInvestorConferences.com 2Viveve to Webcast Live at VirtualInvestorConferences.com 3Maailman ensimmäinen tiedemiesten koulutukseen suunniteltu avoimen innovaation ohjelma käynnistyy 2Maailman ensimmäinen tiedemiesten koulutukseen suunniteltu avoimen innovaation ohjelma käynnistyy 3SHAREHOLDER ALERT: Pomerantz Law Firm Reminds Shareholders with Losses on their Investment in Puma Biotechnology, Inc. of Class Action Lawsuit and Upcoming Deadline - PBYI 2SHAREHOLDER ALERT: Pomerantz Law Firm Reminds Shareholders with Losses on their Investment in Puma Biotechnology, Inc. of Class Action Lawsuit and Upcoming Deadline - PBYI 3SHAREHOLDER ALERT: Pomerantz Law Firm Reminds Shareholders with Losses on their Investment in Puma Biotechnology, Inc. of Class Action Lawsuit and Upcoming Deadline - PBYI 4Biotech Procurement Company Moves to Office 365 with iomart 2
... Advisory Committee to Review Denosumab Data , , THOUSAND ... AMGN ) today announced that the U.S. Food and ... a meeting of the Reproductive Health Drugs Advisory Committee (RHDAC) ... the Biologics License Application (BLA) for denosumab, a RANK Ligand ...
... Pharmaceutical Inc. ("Dragon Pharma" or the "Company" TSX: DDD; ... today announced the results of the Annual Shareholders Meeting ... , There were 50,209,377 shares equaling 74.87% of the ... the following eight persons to serve as members of ...
... Diagnostics, Inc. ("ExosomeDX") and DxS Ltd. ("DxS") today announced ... companion diagnostics for key cancer gene mutations, such as ... DxS, industry leading Scorpions(R) real-time PCR Mutation Test Kits ... harvests high-quality nucleic acids from blood exosomes. , ...
Cached Biology Technology:Amgen to Participate in Reproductive Health Drugs Advisory Committee Meeting in August 2Amgen to Participate in Reproductive Health Drugs Advisory Committee Meeting in August 3Amgen to Participate in Reproductive Health Drugs Advisory Committee Meeting in August 4Amgen to Participate in Reproductive Health Drugs Advisory Committee Meeting in August 5Amgen to Participate in Reproductive Health Drugs Advisory Committee Meeting in August 6Amgen to Participate in Reproductive Health Drugs Advisory Committee Meeting in August 7Exosome Diagnostics and DxS Diagnostic Innovations Collaborate to Develop Blood-Based Tests for Key Cancer Mutations 2
Pancreatic Cell Cryopreservation Medium (2X) is intended for the cryopreservation of LT2 Immortalized Pancreatic Mesenchymal Cells (SCR013) and VIT1 Primary Pancreatic Mesenchymal Cells (SCR014)....
Mouse monoclonal [SH-A1] to S100 alpha ( Abpromise for all tested applications). entrezGeneID: 6271 SwissProtID: P23297...
This application changes sensitive keywords in an FCS file to remove patient information. It was contributed by Dr. David Miller....
Rat monoclonal [HK5.3] to B7 RP1 (Biotin) ( Abpromise for all tested applications). entrezGeneID: 23308 SwissProtID: O75144...
Biology Products: