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Proteins may predict lung transplant rejection

the following became elevated with chronic rejection:

  • matrix metalloprotein-9 (66 times more likely to suffer rejection)
  • proteinase 3 (nine times more likely)

"Preliminary evidence suggests these biomarkers will be an early sign of lung transplant rejection," the authors wrote. The research is continuing to determine which protein combinations are the best predictors and whether some biomarkers may be better than others at different points of the disease's development.

The information could offer inroads to new therapies, said Wendt. Doctors may be able to increase the dose of anti-rejection drugs when the early markers of rejection appear. Or, they may reduce anti-rejection drugs for people who do not show early signs of rejection. (Anti-rejection drugs have their own side effects, including an increased chance of developing kidney disease or malignancies.)

Finally, these findings could be used to understand the physiological mechanisms that lead to lung rejection, Wendt explained. Her team has developed two mouse models to determine whether these proteins play a role in the development of chronic lung rejection or whether they are a byproduct of the disease.
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Source:American Physiological Society


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