Navigation Links
Proteins may behave differently in natural environments

When in an environment similar to that in which they exist naturally, proteins and multiprotein assemblies may demonstrate actions or dynamics different than those they exhibit when in the static form in which they are most often studied, said researchers at Baylor College of Medicine in a report in the current issue of the journal Structure.

In a study using electron cryomicroscopy, Dr. Steven Ludtke, assistant professor of biochemistry and molecular biology and co-director of the National Center for Macromolecular Imaging at BCM, and colleagues from BCM and The University of Texas Southwestern Medical Center in Dallas, found such dynamic behavior in a mutant form of a protein called GroEL, which chaperones or helps misfolded protein molecules fold into the shape that allows them to achieve their purpose in the cells. Misfolded proteins have been implicated in a number of neurodegenerative and other diseases.

Electron cryomicroscopy allows scientists to take very detailed two-dimensional images of individual molecules in a native-like environment. Then, using computers and the science of computational biology, they assemble tens of thousands of such images into three-dimensional models that demonstrate the dynamics of the proteins.

When Ludtke and his colleagues followed this procedure with the GroEL mutant with its sister-protein, GroES, they were surprised. Two of the structures were as they expected, but the third was "a strange-looking structure blown up like a balloon," he said.

"This sort of expansion has never been observed before," he said.

In terms of native GroEL, the finding may indicate the need to look at the chaperone itself more closely.

"The expansion was directly related to the function of the assembly. From a more global perspective, this is strong evidence that we need to study how any macromolecule behaves in a solution environment."
'"/>

Source:Baylor College of Medicine


Page: 1

Related biology news :

1. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
2. Hirsute Or Hairless? Two Proteins May Spell The Difference
3. Proteins stop blood-vessel and tumor growth in mice
4. Proteins spur diabetic mice models to grow blood vessels, nerves
5. Parallel evolution: Proteins do it, too
6. Proteins as parents
7. Proteins anchor memories in our brain
8. Proteins necessary for brain development found to be critical for long-term memory
9. Proteins may predict lung transplant rejection
10. Proteins important in Alzheimers, Parkinsons disease travel in the slow lane
11. Tissue regeneration operates differently than expected
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/20/2016)... MINNEAPOLIS , May 20, 2016  VoiceIt ... technology partnership with VoicePass. By working ... user experience.  Because VoiceIt and VoicePass take slightly ... two engines increases both security and usability. ... expressed excitement about this new partnership. ...
(Date:5/9/2016)... 9, 2016 Elevay is currently ... expanding freedom for high net worth professionals seeking travel ... globally connected world, there is still no substitute for ... duplicate sealing your deal with a firm handshake. This ... taking advantage of citizenship via investment programs like those ...
(Date:4/28/2016)... First quarter 2016:   , Revenues amounted ... quarter of 2015 The gross margin was 49% (27) ... the operating margin was 40% (-13) Earnings per share ... operations was SEK 249.9 M (21.2) , Outlook   ... M. The operating margin for 2016 is estimated to ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... 27, 2016  Global demand for enzymes is ... 2020 to $7.2 billion.  This market includes enzymes ... products, biofuel production, animal feed, and other markets) ... biocatalysts). Food and beverages will remain the largest ... consumption of products containing enzymes in developing regions.  ...
(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... ... to bring innovative medical technologies, services and solutions to the healthcare market. The ... implementation of various distribution, manufacturing, sales and marketing strategies that are necessary to ...
(Date:6/24/2016)... DIEGO , June 24, 2016 ... more sensitively detects cancers susceptible to PARP inhibitors ... circulating tumor cells (CTCs). The new test has ... HRD-targeted therapeutics in multiple cancer types. ... targeting DNA damage response pathways, including PARP, ATM, ...
(Date:6/23/2016)... CAMBRIDGE, Mass. , June 23, 2016 /PRNewswire/ ... the development of novel compounds designed to target ... compound, napabucasin, has been granted Orphan Drug Designation ... in the treatment of gastric cancer, including gastroesophageal ... cancer stemness inhibitor designed to inhibit cancer stemness ...
Breaking Biology Technology: