Navigation Links
Proteins may behave differently in natural environments

When in an environment similar to that in which they exist naturally, proteins and multiprotein assemblies may demonstrate actions or dynamics different than those they exhibit when in the static form in which they are most often studied, said researchers at Baylor College of Medicine in a report in the current issue of the journal Structure.

In a study using electron cryomicroscopy, Dr. Steven Ludtke, assistant professor of biochemistry and molecular biology and co-director of the National Center for Macromolecular Imaging at BCM, and colleagues from BCM and The University of Texas Southwestern Medical Center in Dallas, found such dynamic behavior in a mutant form of a protein called GroEL, which chaperones or helps misfolded protein molecules fold into the shape that allows them to achieve their purpose in the cells. Misfolded proteins have been implicated in a number of neurodegenerative and other diseases.

Electron cryomicroscopy allows scientists to take very detailed two-dimensional images of individual molecules in a native-like environment. Then, using computers and the science of computational biology, they assemble tens of thousands of such images into three-dimensional models that demonstrate the dynamics of the proteins.

When Ludtke and his colleagues followed this procedure with the GroEL mutant with its sister-protein, GroES, they were surprised. Two of the structures were as they expected, but the third was "a strange-looking structure blown up like a balloon," he said.

"This sort of expansion has never been observed before," he said.

In terms of native GroEL, the finding may indicate the need to look at the chaperone itself more closely.

"The expansion was directly related to the function of the assembly. From a more global perspective, this is strong evidence that we need to study how any macromolecule behaves in a solution environment."
'"/>

Source:Baylor College of Medicine


Page: 1

Related biology news :

1. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
2. Hirsute Or Hairless? Two Proteins May Spell The Difference
3. Proteins stop blood-vessel and tumor growth in mice
4. Proteins spur diabetic mice models to grow blood vessels, nerves
5. Parallel evolution: Proteins do it, too
6. Proteins as parents
7. Proteins anchor memories in our brain
8. Proteins necessary for brain development found to be critical for long-term memory
9. Proteins may predict lung transplant rejection
10. Proteins important in Alzheimers, Parkinsons disease travel in the slow lane
11. Tissue regeneration operates differently than expected
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/9/2016)... Elevay is currently known as ... for high net worth professionals seeking travel for work ... world, there is still no substitute for a face-to-face ... your deal with a firm handshake. This is why ... of citizenship via investment programs like those offered by ...
(Date:4/28/2016)... April 28, 2016 First quarter 2016:   ... 966% compared with the first quarter of 2015 The ... 589.1 M (loss: 18.8) and the operating margin was 40% (-13) ... Cash flow from operations was SEK 249.9 M (21.2) ... guidance is unchanged, SEK 7,000-8,500 M. The operating margin ...
(Date:4/19/2016)... 20, 2016 The new GEZE ... compact web-based "all-in-one" system solution for all door components. ... or the door interface with integration authorization management system, ... systems. The minimal dimensions of the access control and ... building installations offer considerable freedom of design with regard ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... 23, 2016 , ... Charm Sciences, Inc. is pleased to ... AOAC Research Institute approval 061601. , “This is another AOAC-RI approval of the ... Vice President of Regulatory and Industrial Affairs. “The Peel Plate methods perform comparably ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... announced the launch of the Supplyframe Design Lab . Located in Pasadena, ... explore the future of how hardware projects are designed, built and brought to ...
(Date:6/23/2016)... BEACH, Calif. , June 23, 2016  Blueprint ... new biological discoveries to the medical community, has closed ... co-founder Matthew Nunez . "We have ... us with the capital we need to meet our ... will essentially provide us the runway to complete validation ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... quality, regulatory and technical consulting, provides a free webinar on Performing ... July 13, 2016 at 12pm CT at no charge. , Incomplete investigations are ...
Breaking Biology Technology: