Navigation Links
Proteins important in Alzheimer's, Parkinson's disease travel in the slow lane

Using a novel video-imaging system, researchers at the University of Pennsylvania School of Medicine have been able to observe proteins important in Alzheimer’s and Parkinson’s disease moving along axons, extensions of nerve cells that carry proteins away from the cell body. Understanding this process of axonal transport is important for studying many neurodegenerative diseases. The study appeared in the Journal of Neuroscience.

Axonal transport often breaks down and many neurodegenerative diseases are characterized by defects in this process. Of particular interest is a group of transported proteins called slow component-b that includes synuclein and tau, disease proteins involved in Parkinson’s and Alzheimer’s disease, respectively, in addition to many other proteins critical for axonal growth and regeneration.

"There are two basic transport groups called fast and slow components, with a 200 to 300 fold difference in average velocities," says first author Subhojit Roy, MD, PhD, a neuropathologist and Research Associate in the Department of Pathology and Laboratory Medicine. "While scientists have seen proteins in the fast component move rapidly to the tip of the axon, until now, mechanisms of the slow movement of these disease-related proteins have been unclear as their transport had not been directly visualized."

Roy devised a system to simultaneously visualize the transport of two labeled slow-component-b proteins in living cultured mouse axons. This clarified unique aspects of slow-protein transport. He found that the "slow" proteins actually showed rapid bursts of movement followed by pauses. This intermittent transport behavior of individual cargoes made the overall population slow and suggests that fast and slow proteins use the same basic mechanisms for transport.

Surprisingly, the videos also revealed that multiple slow proteins are transported together as "packets," essentially piggy-backing on each other, possibly on the same specialized proteins called molecular motors. "It makes sense when you think about it ?why would the neurons spend so much energy transporting proteins separately when they’re going to the same place anyway, like car pooling" speculates Roy.

"Our study reveals novel aspects of axonal transport of an important class of proteins, namely the slow component-b proteins, and also opens up new avenues for investigating axonal transport defects in neurodegenerative diseases," concludes Roy.
'"/>

Source:University of Pennsylvania School of Medicine


Related biology news :

1. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
2. Hirsute Or Hairless? Two Proteins May Spell The Difference
3. Proteins stop blood-vessel and tumor growth in mice
4. Proteins spur diabetic mice models to grow blood vessels, nerves
5. Parallel evolution: Proteins do it, too
6. Proteins as parents
7. Proteins anchor memories in our brain
8. Proteins may behave differently in natural environments
9. Proteins necessary for brain development found to be critical for long-term memory
10. Proteins may predict lung transplant rejection
11. Nature provides inspiration for important new adhesive

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/14/2017)... 2017  Wake Forest Baptist Medical Center today announced Julie ... executive officer (CEO). Freischlag joins the medical center on ... , M.D., who last year announced that he would ... after leading it since 2008.   As ... Forest Baptist,s academic health system, which includes Wake Forest ...
(Date:2/10/2017)... Research and Markets has announced the addition of ... Commercial Aspects" to their offering. ... Biomarkers play an important ... selection of treatment as well for monitoring the results. There ... modern medicine. Biochip/microarray technologies and next generation sequencing are also ...
(Date:2/8/2017)... (NASDAQ: AWRE ), a leading supplier of biometrics ... and year ended December 31, 2016. Revenue ... to $6.9 million in the same quarter last year. Operating ... compared to $2.6 million in the fourth quarter of 2015. ... million, or $0.02 per diluted share, which compares to $1.8 ...
Breaking Biology News(10 mins):
(Date:3/23/2017)... Mass. , March 23, 2017 /PRNewswire/ ... partner to global in vitro diagnostics manufacturers ... of the industry,s first multiplexed Inherited ... disease testing by next-generation sequencing (NGS). The ... were developed with input from industry experts ...
(Date:3/23/2017)... NetworkNewsWire Editorial Coverage  ... Cancer remains one of ... health care systems, in terms of costs and resources. However, ... the development of innovative and efficient therapies that demonstrate higher ... types of cancer treatments, a growing number of patients receiving ...
(Date:3/22/2017)... -- Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN), today announced a major ... and GSK to generate genetic sequence data from the 500,000 ... enable researchers to gain valuable insights to support advances in ... serious and life threatening diseases. ... Genetic evidence has revolutionized scientific ...
(Date:3/22/2017)... JERUSALEM , March 22, 2017 ... ( www.oramed.com ), ... of oral drug delivery systems, announced today that ... Officer, will deliver a presentation titled, "Oral Insulin ... upcoming Cambridge Healthtech Institute,s Oligonucleotide and Peptide Therapeutics ...
Breaking Biology Technology: