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Protein therapy may reduce infarct size in heart attack patients

ssessed safety and cardiac outcomes through six months. This trial was designed as an exploratory study to assess the potential impact of KAI-9803 in this “first-in-human?study.

Results indicate that KAI-9803 may be associated with less myocardial necrosis with lower CK-MB AUC values at all dose levels. Furthermore, improved tissue perfusion (measured during coronary angiography after stent implantation and by continuous electrocardiogram recordings) and reduced infarct size (measured 14 days after the heart attack) were observed at the 0.5 mg (infarct size 23 vs. 29.5% of the left ventricle) and 1.25 mg (infarct size 32.5 vs. 43% of the left ventricle) dose levels. No major safety concerns were demonstrated with the therapy since the incidence of serious adverse events was similar among patients treated with KAI-9803 compared to placebo, even at the highest dose levels of the study.

"In this early study, we believe the data suggest a potential therapeutic role for KAI-9803,?said Matthew Roe, M.D., of the Duke Clinical Research Institute and lead author of the study. “The drug was associated with a favorable safety and tolerability profile and based on this ‘first in human?trial, we are interested in pursing larger studies to determine the therapeutic value of this treatment for heart attack patients receiving reperfusion therapy."


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Source:American College of Cardiology


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