Navigation Links
Protein therapy may reduce infarct size in heart attack patients

Researchers are searching for new methods and therapies to reduce infarct size and improve blood flow to the heart muscle in patients who experience myocardial infarction (MI), or heart attack.

In a study presented today at the American College of Cardiology’s Innovation in Intervention: i2 Summit in New Orleans, La., a team from the Duke Clinical Research Institute presented the results from a Phase 1 study evaluating a novel protein kinase C inhibitor that had shown benefit in animal models, but had not previously been studied in humans. This first-in-human study suggests that this new drug may have promise as a potential therapeutic agent in heart attack patients. Innovation in Intervention: i2 Summit is an annual meeting for practicing cardiovascular interventionalists sponsored by the American College of Cardiology in partnership with the Society for Cardiovascular Angiography and Interventions.

Heart attacks are caused by blockages in the coronary artery preventing blood flow to the heart muscle. Restoring blood flow to the heart improves clinical outcomes in heart attack patients, but there remains significant injury to heart muscle cells. Protein kinase C (PKC) is activated in these heart cells, initiating a series of events that can cause further damage to the heart. Animal studies have suggested that KAI-9803, an inhibitor of PKC, may reduce injury in damaged heart muscle cells, but this class of therapies had not previously been studied in heart attack patients.

In the DELTA MI trial, the DCRI team evaluated KAI-9803 in 154 patients with anterior ST-elevation MI undergoing primary percutaneous coronary intervention with balloon angioplasty and coronary stent implantation. Patients were randomized 2:1 to receive intracoronary injections of the active study drug (KAI-9803) vs. placebo in four dose groups (0.05, 0.5, 1.25 or 5.0 mg of KAI-9803). Researchers performed tests to assess heart function at various time points and a
'"/>

Source:American College of Cardiology


Page: 1 2

Related biology news :

1. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
2. Protein discovery could unlock the secret to better TB treatment
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. An HIV Protein Plays a Surprising Role in Gene Activation
5. Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease
6. New SARS Protein Linked To Important Cell Doorway
7. The Shapes Of Life: NIGMS Project Yields More Than 1,000 Protein Structures
8. PANTHER Protein Classification System Database 5.0
9. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
10. Newly Discovered Compound Blocks Known Cancer-Causing Protein
11. UF Researchers Map Bacterial Proteins That Cause Tooth Loss

Post Your Comments:
(Date:11/24/2009)..., 2009) -- The Wildlife Conservation Society (WCS)...remaining population of Siberian tigers has likely...poaching and habitat loss. , WCS say... what needs to be done to protect remaining popula... The report was released by the Siberian Tiger Mon...
(Date:11/24/2009)...h . , The presence of increased body fat, an...es in the blood, hinders the loss and maintenance ...the University of Navarra conducted by Estbaliz Go...cy. , The project, entitled "A nutrigenetic and ...ody weight and inflammation," examines how the ind...
(Date:11/23/2009)...me of day matters to forest trees dealing with dro...rch team led by Professor Malcolm Campbell, Univer...esearch and colleagues in the department of cell a... Capitalizing on their previous work to decode the...ined how poplar trees use their 45,000 genes to re...
Breaking Biology News(10 mins):Report shows dramatic decline in Siberian tigers 2It can be predicted the reaction obese patients will have to a diet 2Time of day matters to thirsty trees, U of T researcher discovers 2Vertical Measures Announces its Version of Healthcare Reform by Giving Away 5K in Internet Marketing Services 58840 1Vertical Measures Announces its Version of Healthcare Reform by Giving Away 5K in Internet Marketing Services 58840 2Vertical Measures Announces its Version of Healthcare Reform by Giving Away 5K in Internet Marketing Services 58840 3Child burn injuries down significantly 58836 1Child burn injuries down significantly 58836 2Child burn injuries down significantly 58836 3AMERIGROUP Foundation Supports Groundbreaking on Grommet Island Park for People With Disabilities 14342 1AMERIGROUP Foundation Supports Groundbreaking on Grommet Island Park for People With Disabilities 14342 2
...ters in 11 states are the latest members of the Na...ional Science Award (CTSA) consortium. Creating a ...ross the nation, the consortium is working to redu... become treatments for patients and to engage comm...ulfilling the critical need to train the next gene...
... cyclic increase and decrease of jellyfish populat...ne of the U.S.,s most productive fisheries--into v...dy shows that the availability of food for jellyfi...jellyfish population, even while other factors, su...nued growth. , These results indicate that "antic...
...ghout the overlooked depths of Lake Michigan and o...rapidly disappearing. , Until recently, the anima...oreia - was a major food source for commercially i... fish upon which salmon, trout and walleye rely. ,... a quest to explain their population freefall, whi...
Other Biology News:NIH expands national consortium dedicated to transforming clinical and translational research 2NIH expands national consortium dedicated to transforming clinical and translational research 3Scientists discover stinging truths about jellyfish blooms in the Bering Sea 2Scientists discover stinging truths about jellyfish blooms in the Bering Sea 3A Great Lakes mystery: The case of the disappearing species 2A Great Lakes mystery: The case of the disappearing species 3A Great Lakes mystery: The case of the disappearing species 4
(Date:11/24/2009)... , REYKJAVIK, Iceland, November 24...Nasdaq: DCGN ) today announced the approval of all... Court for the District of Delaware,(the "Bankrupt...ition for,relief under Chapter 11 of the United St..., The orders issued by the Bankruptcy Court...
(Date:11/24/2009)..., SEATTLE, Nov. 24 Blue Marble Ene... Odessa Public Development Authority (OPDA) were r...ommunity Economic Revitalization Board (CERB) in a...,s first specialty biochemical biorefinery in Linc...ificantly speed the development of our biorefinery...
(Date:11/24/2009)..., DUBLIN, November 24 /PRNewswire-FirstCall/ ...al specialty biopharmaceutical company, today,anno...Medicines Agency for,velaglucerase alfa, the compa... the treatment of Type 1 Gaucher disease. This is ...alfa that has been submitted, with previous,submis...
(Date:11/24/2009)... Program Connects Customers with Pa...llected with DNA Genotek Products , ... DNA Genotek , a leading provider of products for...reparation, today announced its new global partner...nts for DNA Genotek,s partner community and is des...
Breaking Biology Technology:deCODE genetics, Inc. Announces Approval of First Day Motions by Bankruptcy Court 2deCODE genetics, Inc. Announces Approval of First Day Motions by Bankruptcy Court 3Blue Marble Energy, OPDA Awarded $2M by WA's Community Economic Revitalization Board 2Shire Submits European Marketing Authorization Application (MAA) for velaglucerase alfa for the Treatment of Type 1 Gaucher Disease 2Shire Submits European Marketing Authorization Application (MAA) for velaglucerase alfa for the Treatment of Type 1 Gaucher Disease 3Shire Submits European Marketing Authorization Application (MAA) for velaglucerase alfa for the Treatment of Type 1 Gaucher Disease 4DNA Genotek Launches Global Partner Program 2DNA Genotek Launches Global Partner Program 3
...Jones II named Vice President and General Manager ...lion prescriptions a week, FRANKLIN LAKES, N.J., ...), one of the nation,s leading pharmacy benefit,ma... Whitestown, Indiana,will be the home of world,s l...g a nearly year-long search that spanned 48 states...
...Mass., Dec. 18 ActivBiotics, Inc. today,announced...r its clinical,trial of Rifalazil failed in periph...ling all or substantially all of its assets on an ...t of Creditors, process. The,Assignee of the asset...s,below). The bidding for the assets, which may be...
...Mich., Dec. 18 Stryker Corporation,(NYSE: SYK ) ...ednesday,January 23, 2008 at 4:30 p.m., Eastern Ti... the quarter and year ended December 31, 2007 and,...or the quarter and year,ended December 31, 2007 wi... MacMillan, President and Chief Executive Officer,...
Other Biology Technology:Medco Chooses AllPoints at Anson in Whitestown, Indiana as Site for the World's Largest, Most-Advanced Automated Pharmacy 2Medco Chooses AllPoints at Anson in Whitestown, Indiana as Site for the World's Largest, Most-Advanced Automated Pharmacy 3Medco Chooses AllPoints at Anson in Whitestown, Indiana as Site for the World's Largest, Most-Advanced Automated Pharmacy 4Medco Chooses AllPoints at Anson in Whitestown, Indiana as Site for the World's Largest, Most-Advanced Automated Pharmacy 5ActivBiotics Sells Proprietary Assets, Including Drug Product Candidates 2ActivBiotics Sells Proprietary Assets, Including Drug Product Candidates 3Stryker to Host Conference Call on January 23, 2008 2
... for agitation and mixing applications such as ove... destaining of gels and blots, and Southern hybrid...l (8-40 rpm) and can handle a maximum load of 4.5 ...tforms covered with nonsolid rubber mats that can ...
CD43 MicroBeads, rat from Miltenyi Biotec
Bac-to-Bac Baculovirus Expression System from Invitrogen
...ader for cellular assays, assay development and hi...orescence and luminescence modalities., The H... highlight our companys decades-long experience in...gradable, and fully integrated system., Versatil...
Biology Products: