Navigation Links
Protein therapy may reduce infarct size in heart attack patients

Researchers are searching for new methods and therapies to reduce infarct size and improve blood flow to the heart muscle in patients who experience myocardial infarction (MI), or heart attack.

In a study presented today at the American College of Cardiology’s Innovation in Intervention: i2 Summit in New Orleans, La., a team from the Duke Clinical Research Institute presented the results from a Phase 1 study evaluating a novel protein kinase C inhibitor that had shown benefit in animal models, but had not previously been studied in humans. This first-in-human study suggests that this new drug may have promise as a potential therapeutic agent in heart attack patients. Innovation in Intervention: i2 Summit is an annual meeting for practicing cardiovascular interventionalists sponsored by the American College of Cardiology in partnership with the Society for Cardiovascular Angiography and Interventions.

Heart attacks are caused by blockages in the coronary artery preventing blood flow to the heart muscle. Restoring blood flow to the heart improves clinical outcomes in heart attack patients, but there remains significant injury to heart muscle cells. Protein kinase C (PKC) is activated in these heart cells, initiating a series of events that can cause further damage to the heart. Animal studies have suggested that KAI-9803, an inhibitor of PKC, may reduce injury in damaged heart muscle cells, but this class of therapies had not previously been studied in heart attack patients.

In the DELTA MI trial, the DCRI team evaluated KAI-9803 in 154 patients with anterior ST-elevation MI undergoing primary percutaneous coronary intervention with balloon angioplasty and coronary stent implantation. Patients were randomized 2:1 to receive intracoronary injections of the active study drug (KAI-9803) vs. placebo in four dose groups (0.05, 0.5, 1.25 or 5.0 mg of KAI-9803). Researchers performed tests to assess heart function at various time points and a
'"/>

Source:American College of Cardiology


Page: 1 2

Related biology news :

1. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
2. Protein discovery could unlock the secret to better TB treatment
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. An HIV Protein Plays a Surprising Role in Gene Activation
5. Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease
6. New SARS Protein Linked To Important Cell Doorway
7. The Shapes Of Life: NIGMS Project Yields More Than 1,000 Protein Structures
8. PANTHER Protein Classification System Database 5.0
9. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
10. Newly Discovered Compound Blocks Known Cancer-Causing Protein
11. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Protein therapy may reduce infarct size heart attack patients

(Date:9/2/2014)... September 2, 2014 A study published in ... of the American Academy of Child and Adolescent ... with a psychiatric diagnosis had an increased risk ... antipsychotics. , Using data from the nationwide Danish ... Ren Ernst Nielsen, Psychiatry, Aalborg University Hospital, Denmark, ...
(Date:9/2/2014)... of lithographic limestone is well known as a ... that area (for example, Archaeopteryx). Now, for the ... the French equivalent of these outcrops - discoveries ... known water treader. , Despite the abundance of ... have been obtained from the Late Kimmeridgian equivalents ...
(Date:9/1/2014)... in the U.S. has improved steadily in recent yearsspurred ... dietary quality remains poor and disparities continue to widen ... study from Harvard School of Public Health (HSPH). , ... that the extensive efforts by many groups and individuals ... but it also indicates that these efforts need to ...
Breaking Biology News(10 mins):Risk of diabetes in children and adolescents exposed to antipsychotics 2Exceptionally well preserved insect fossils from the Rhône Valley 2Quality of US diet shows modest improvement, but overall remains poor 2Quality of US diet shows modest improvement, but overall remains poor 3
... in German . It,s a quick process, ... seconds, a laser beam has welded the casing and speedometer cover ... is a perfect weld seam scarcely visible to the naked eye. ... welding. What,s more: the resulting heat is confined to a minimal ...
... Columbia have been able to pinpoint more of the ... valuable compounds to the roasting process. Lead author ... the prevailing antioxidants present in dark roasted coffee brew ... high temperatures. Their findings will appear in ...
... of Zaragoza (UNIZAR) has studied precipitation trends in Spain,s ... The results show that precipitation has declined overall between ... of the rainy season. The rains are heavier in ... ,Since 1946, the average precipitation falling on Spanish hydrological ...
Cached Biology News:Laser welding in the right light 2Roasting coffee beans a dark brown produces valued antioxidants: UBC food scientists 2Rain in Spain is on the decline 2
(Date:9/1/2014)... Albany, NewYork (PRWEB) September 01, 2014 ... Pharma, Biotech and Diagnostics report provides comprehensive understanding ... and agreements entered into by the worlds leading ... detailed understand and analysis of how and why ... flexibility of a prospective partner’s negotiated deals terms ...
(Date:8/31/2014)... 31, 2014 2014 Market ... a professional and in-depth research report on ... Polyacrylamide information, including Polyacrylamide definition, classification, application, ... industry overview. This research covers the international ... as global industry analysis covering macroeconomic environment ...
(Date:8/29/2014)... SAN DIEGO, Aug. 29, 2014  Pfenex Inc. ... in the development of high-value and difficult to ... business update and reported financial results for the ... "With the successful completion of our initial public ... advance our biosimilar product candidates, derived from our ...
(Date:8/29/2014)... According to a new market report published by Transparency ... valued at USD 3,754.6 million in 2012 and is estimated ... CAGR of 5.9% from 2013 to 2019. , Nearly half ... by bone and joint disorders, and this number is expected ... will continue to increase the demand for orthobiologics. Other factors ...
Breaking Biology Technology:Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 2Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 3Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 4International Polyacrylamide Industry & Copper Iodide Market Data Analysis Now Available at DeepResearchReports.com 2International Polyacrylamide Industry & Copper Iodide Market Data Analysis Now Available at DeepResearchReports.com 3Pfenex Reports Second Quarter 2014 Results and Provides Business Update 2Pfenex Reports Second Quarter 2014 Results and Provides Business Update 3Pfenex Reports Second Quarter 2014 Results and Provides Business Update 4Pfenex Reports Second Quarter 2014 Results and Provides Business Update 5Pfenex Reports Second Quarter 2014 Results and Provides Business Update 6Pfenex Reports Second Quarter 2014 Results and Provides Business Update 7Pfenex Reports Second Quarter 2014 Results and Provides Business Update 8Global Orthobiologics Market to Reach $5,519.9 Million by 2019: Transparency Market Research 2Global Orthobiologics Market to Reach $5,519.9 Million by 2019: Transparency Market Research 3
... Researcher Provides Extensive Experience In Molecular DiagnosticsSALT LAKE ... company revolutionizing spine care through the development of ... Macina, Ph.D., has joined the executive management team ... and Development. Dr. Macina will report directly to ...
... Feb. 24 Innovative Biosensors, Inc., and ProGenTech ... diagnostics, today announced an agreement to jointly develop ... incorporate Innovative Biosensor,s proprietary Cellular Analysis and Notification ... cell-based approach for quickly detecting various pathogens, into ...
... the gene that ultimately controls the production of tooth ... to the repair of damaged enamel, a new concept ... of replacement teeth. , The gene, called Ctip2, is ... several functions - in immune response, and the development ...
Cached Biology Technology:Axial Biotech Appoints Dr. Roberto Macina to Vice President of Research and Development 2Innovative Biosensors and ProGenTech Partner to Develop a Rapid Diagnostics System 2Innovative Biosensors and ProGenTech Partner to Develop a Rapid Diagnostics System 3Genetic discovery could lead to advances in dental treatment 2
... designed to rapidly and reliably amplify unknown ... Technology. APAgene provides hassle-free, ready-to use components, ... ingredients are provided in each kit. The ... gap filling, localized cloning of genomic DNA, ...
No description available in Ensembl. Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
Rabbit polyclonal to Yaf9 ( Abpromise for all tested applications)....
... is designed to deparaffinize and perform Heat ... paraffin-embedded tissue sections mounted on glass microscope ... paraffin at the high temperature used in ... of the paraffin by detergent. Formaldehyde fixation ...
Biology Products: