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Protein shown to rally biological clock

was perfectly fine. Instead, the oscillations got bigger.?

Herzog likens VIP to the Pony Express rider telling all the SCN cells to synchronize their ; GABA, he says, is like the marshal that prevents he cells from being too active.

Herzog and Aton recorded neuron activity from the SCN using a multielectrode array with 60 electrodes upon which they place SCN cells, a “clock in a dish.? They also recorded gene expression in real-time using a bioluminescent reporter of gene activity.

Using drugs or genetic knock out mice, they negated the role of GABA and recorded the electrical activity of many neurons, what Herzog calls the “hands of the clock,?and the gene activities, “the cogs of the clock,?of many SCN cells.

They found that, without GABA, the cells marched together, but without VIP, they lost synchrony, indicating that VIP is the coordinator.
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Source:Washington University in St. Louis


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