Navigation Links
Protein sensor for fatty acid buildup in mitochondria

nts. Most of the cell's energy-rich molecules called ATP are made in the mitochondria, and these ATP molecules serve as the "currency" with which the cell can "buy" all of the biochemical reactions that keep the cell alive and performing its functions. Virtually all cells have mitochondria, and disruption of their function can cause a variety of diseases.

"Our study showed the connection between the location of PanK2 in the mitochondria and its role in as a sensor of energy demand," said Yong-Mei Zhang, Ph.D., a researcher in the Infectious Diseases department at St. Jude and the report's senior author. "This is an ideal location for PanK2 because it can detect acylcarnitine as it enters the mitochondrion."

The importance of PanK2 is especially evident in individuals who have mutations in the PANK2 gene that give rise to PanK-associated neurodegeneration (PKAN), an inherited disease in which patients have intellectual impairment and difficulty in walking and speaking.

"The new understanding of PanK2 activity and its location in the cell suggests a potential treatment strategy for PKAN," said Roberta Leonardi, Ph.D., a postdoctoral fellow in the St. Jude Infectious Diseases department and first author of the PNAS article. "For example, reducing the level of fat in the diet and taking carnitine supplements might help PKAN patients cope with this debilitating disease."

"One of our challenges is how to develop an animal model of this disease that we can use to determine if reduced dietary fat and carnitine supplements offer hope in the treatment of PKAN in humans," said Suzanne Jackowski, Ph.D., a member of the Infectious Diseases department at St. Jude and a co-author of the report.


'"/>

Source:St. Jude Children's Research Hospital


Page: 1 2

Related biology news :

1. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
2. Protein discovery could unlock the secret to better TB treatment
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. An HIV Protein Plays a Surprising Role in Gene Activation
5. Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease
6. New SARS Protein Linked To Important Cell Doorway
7. The Shapes Of Life: NIGMS Project Yields More Than 1,000 Protein Structures
8. PANTHER Protein Classification System Database 5.0
9. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
10. Newly Discovered Compound Blocks Known Cancer-Causing Protein
11. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Protein sensor for fatty acid buildup mitochondria

(Date:4/9/2015)... JOSE, Calif. , April 9, 2015 ... human interface solutions, announced today that it will report ... on Thursday, April 23, 2015, after the close of ... for analysts and investors at 2:00 p.m. PT (5:00 ...   To participate on the live call, ...
(Date:4/2/2015)... -- At its 2015 ACMG Annual Clinical Genetics Meeting ... American College of Medical Genetics and Genomics (ACMG) announced ... Members of the ACMG Board of Directors serve as ... its policies and programs. ACMG is the national organization ... eventful time in medical genetics and genomics.  We are ...
(Date:4/1/2015)... Medisafe ™, the leading global medication management platform with ... Android smartphones and tablets, announces today that ... allow patients to track and correlate their adherence directly ... be able to visualize in real-time how taking medication ... glucose levels and blood pressure. "Patients need ...
Breaking Biology News(10 mins):Synaptics to Report Third Quarter Results on April 23 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8Medisafe Announces Launch of Biometric Integration, Enabling Patients to Stay Adherent to Their Meds and See Tangible Health Results 2
... synthesis just published in Environmental Reviews reveals ... to address significant environmental, social and economic impacts of ... of climate change on the distribution of invasive alien ... prediction in a warming world" is the collaborative effort ...
... /PRNewswire-iReach/ -- Global Information Inc. (GII) is ... and networking events in the pharmaceuticals and biotechnology ... platform for researchers and decision makers in biotechnology ... learn about significant developments in the biotechnology and ...
... -- Fruit flies don,t have noses, but a huge part ... rely on the sense of smell more than any other ... danger. UW-Madison researchers have discovered that a gene called ... and respond to smells. As reported in the current ...
Cached Biology News:Climate change invites alien invaders Is Canada ready? 22012 Biotechnology and Pharmaceuticals: Forthcoming Conferences and Exhibitions 22012 Biotechnology and Pharmaceuticals: Forthcoming Conferences and Exhibitions 32012 Biotechnology and Pharmaceuticals: Forthcoming Conferences and Exhibitions 4Researchers find gene critical to sense of smell in fruit fly 2Researchers find gene critical to sense of smell in fruit fly 3
(Date:5/5/2015)... 05, 2015 Hayden-McNeil is ... develop custom course materials for smaller courses. This program ... low as 200 students. , “I’m very excited ... of higher education instructors,” said Jeff McCarthy, Hayden-McNeil president. ... can do our part to make education both more ...
(Date:5/5/2015)... , May 5, 2015  Renova™ Therapeutics, ... congestive heart failure and other chronic diseases, has ... independent analysis designed to reflect the healthcare patterns ... This model will be used to characterize the ... could have on those groups of patients and ...
(Date:5/5/2015)... Franz Inc ., the leading supplier of Semantic ... AllegroGraph, has been named a Champion by Bloor Research in ... AllegroGraph is a high performance Semantic Graph Database that enables ... skyrocketing in popularity and have grown by 400% in the ... by DB-Engines. , “We are excited that Graph and ...
(Date:5/5/2015)...   Tocagen Inc. , a clinical-stage immuno-oncology ... , M.D., a venture partner at New Enterprise ... of directors of Tocagen. Dr. Parkinson has more ... development, including leading clinical activities at Amgen and ... cancer therapeutics Gleevec®, Femara®, Zometa®, Kepivance® and Vectibix®, ...
Breaking Biology Technology:Hayden-McNeil Expands Publishing Program to Service Lower Enrollment Courses 2RAND Health Advisory Services modeling heart failure patient outcomes to inform potential impact of Renova Therapeutics lead product candidate 2RAND Health Advisory Services modeling heart failure patient outcomes to inform potential impact of Renova Therapeutics lead product candidate 3Bloor Research Positions AllegroGraph as a ‘Champion’ in Burgeoning Graph Database Market 2Bloor Research Positions AllegroGraph as a ‘Champion’ in Burgeoning Graph Database Market 3Tocagen Appoints David R. Parkinson, M.D., to the Board of Directors 2Tocagen Appoints David R. Parkinson, M.D., to the Board of Directors 3Tocagen Appoints David R. Parkinson, M.D., to the Board of Directors 4
... in 131.4% Increase in Revenue and Positive ... EBITDA for Three Consecutive Quarters, PRINCETON, ... development and protein production company, today,announced record growth in revenues ... period last year and generated positive EBITDA for,the third consecutive ...
... is so 2007. This,year scientists in North Carolina have ... Going Blue., This new charge is coming out ... country,s newest business incubators that,discovers, develops and markets new ... Blue initiative broadens the focus of environmental awareness,from land-based ...
... With Regional Perspective, PHILADELPHIA and LONDON, April ... information solutions to the worldwide,research and business communities, ... been added to Web of Science. The newly ... rather than,international audience by approaching subjects from a ...
Cached Biology Technology:Laureate Pharma Reports Record Growth for 2007 2Laureate Pharma Reports Record Growth for 2007 3When it Comes to Going Green, These N.C. Scientists are Singing the Blues 2Thomson Scientific Begins Expansion of Web of Science 2
... based purification systems provide high speed purification ... They offer increased throughput and reproducible results. ... KingFisher mL and KingFisher 96, covering sample ... system consists of an instrument, specially designed ...
Candida (IgA) -Ab EIA Sample Size: 5 l...
... Principle: The Oxidized LDL Competitive ELISA ... LDL in the sample competes with a fixed ... well for the binding of the biotin- labeled ... 25 l The Oxidized LDL Competitive ...
OptiBuffer is a fully optimised medium, designed for,the electroporation of eukaryotic cells. OptiBuffer,improves both transfection efficiencies and survival,rates over PBS or other standard culture...
Biology Products: