Navigation Links
Protein key to organ growth

When amounts of a small protein called TCTP (translationally controlled tumor protein) are reduced in the cells of fruit flies, they are smaller than normal, indicating that the protein plays a major role in the growth and proliferation of cells, said researchers at Baylor College of Medicine in a report in current issue of the journal Nature.

Work in his laboratory shows that TCTP plays a role in regulating Rheb (Ras homologue enriched in brain), a protein controlling growth and differentiation, and may give clues to treatment of a particular benign disease called tuberous sclerosis that is associated with the control exerted through the same pathway, said Dr. Kwang-Wook Choi, associate professor of molecular and cellular biology at BCM and his colleagues.

When flies completely lack the protein, they do not live very long. However, when flies have only a little TCTP in their cells, they are very small, said Choi. Graduate student Ya-Chieh Hsu, through a series of studies that concentrated on the effect of the protein on the eyes and wings, elucidated the role of TCTP in the cell.

"She was able to show genetically and biochemically that TCTP is directly involved in regulating Rheb function so that it regulates cell size as well as cell numbers. We found that in the case of dysfunction, the eyes and wings get smaller," said Choi. "If you completely knock out this function in the eye, they have no eyes."

TCTP was of interest because it is over-expressed or overabundant in cancer cells.

"If you reduce the levels of TCTP, tumor cells revert to normal in the laboratory," said Choi. However, in their studies of fruit flies, Choi and his colleagues found when the protein is lacking, it has a profound effect on flies. However, too much does not cause tumor growth. Choi is also a faculty member of the BCM Graduate School of Biomedical Sciences.
'"/>

Source:Baylor College of Medicine


Page: 1

Related biology news :

1. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
2. Protein discovery could unlock the secret to better TB treatment
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. An HIV Protein Plays a Surprising Role in Gene Activation
5. Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease
6. New SARS Protein Linked To Important Cell Doorway
7. The Shapes Of Life: NIGMS Project Yields More Than 1,000 Protein Structures
8. PANTHER Protein Classification System Database 5.0
9. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
10. Newly Discovered Compound Blocks Known Cancer-Causing Protein
11. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Protein key organ growth

(Date:4/21/2015)... Canada , April 21, 2015 ... and evolving government policies are boosting access control systems ... According to a recently published report by ... Opportunities, 2020 ", the access control systems market in ... nearly USD1.2 billion by 2020.The access control systems market ...
(Date:4/20/2015)... The announcement comes as demand ... Management (GRM), Ireland,s foremost records management ... built up an impressive track record of clients within the ... the records management sector in Dubai . ... staffbase and employ a further eight staff members at its ...
(Date:4/14/2015)...  HYPR Corp. today announced it has joined ... tm , an industry consortium transforming online authentication ... technology and collaborate to deliver open specifications for ... and private, and easier to use. ... sensitive user information and eliminates the dependency on ...
Breaking Biology News(10 mins):Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3
... Cancer Research Foundation, a non-profit organization focused on ... recipients of the Dale F. Frey Award for ... funding to scientists completing a prestigious Damon Runyon ... highest expectations and are most likely to make ...
... been in use for decades. But manufacturers are ... new developments: Substantial influences of the microscopic material ... directly. The synthetic polymer molecules are simply too ... team of physicists led by professor Andreas Bausch ...
... are developing technology that could ultimately sequence a person,s ... cost of current commercial techniques. The researchers have ... lead to an ultrafast commercial DNA sequencing tool within ... published this month in the journal , Nano Letters ...
Cached Biology News:Damon Runyon Cancer Research Foundation awards breakthrough scientists 2Muscle filaments make mechanical strain visible 2Your genome in minutes: New technology could slash sequencing time 2Your genome in minutes: New technology could slash sequencing time 3
(Date:5/28/2015)... MARLBOROUGH, Mass. , May 28, 2015 ... company focused on discovering and developing innovative therapeutics, primarily ... the pricing of a public offering of 26 million ... per share for gross proceeds of approximately $10.4 million. ... stock, (ii) a 13-month overallotment purchase right to purchase ...
(Date:5/28/2015)...  GenVec, Inc. (Nasdaq: GNVC ) today announced ... , will present a company overview at the Jefferies ... Thursday, June 4, 2015. The live ... available at the following link:  http://wsw.com/webcast/jeff88/gnvc .  This ... access, visit www.genvec.com , click on "Investors and ...
(Date:5/28/2015)... The Fertility Centers of New England is proud to ... on a new and expanded role as Medical Director. ... oversight and quality assurance for the practice. , “We ... of experienced reproductive endocrinologists,” said Fertility Centers of New ... expertise and compassionate, individualized care have helped set FCNE ...
(Date:5/28/2015)... York, NY (PRWEB) May 28, 2015 ... renewed and enhanced its long term partnership with PTI ... work together to provide clients with custom-tailored method ... the art instruments currently available. The agreement includes a ... companies’ employees across organizational lines. This enables a ...
Breaking Biology Technology:RXi Pharmaceuticals Announces $10 Million Public Offering of Common Stock and Warrants 2RXi Pharmaceuticals Announces $10 Million Public Offering of Common Stock and Warrants 3GenVec To Present At The Jefferies Healthcare Conference 2Danielle Vitiello, MD of Fertility Centers of New England, Named New Medical Director 2Whitehouse Labs Renews & Enhances Partnership with PTI Inspection Systems 2Whitehouse Labs Renews & Enhances Partnership with PTI Inspection Systems 3
... (Nasdaq and SWX: BMRN) announced today that Asubio,Pharma ... received marketing,approval from the Japanese Ministry of Health, ... Biopten(R) (sapropterin dihydrochloride), which,contains the same active ingredient ... patients with phenylketonuria (PKU). BioMarin will receive a,milestone ...
... and EM Holdings B.V. (the,"Concerned Shareholders") are disappointed ... in Biovail ,s press release issued earlier today., ... date has been misinformation,coming from Biovail. Once again, ... tactics," stated Bruce Brydon, one of the Concerned ...
... Party Administrators,Alliance (TPAA) announced today the appointment of ... nation,s first alliance of third party,administrators and provides ... its members., Oelschlager brings hands-on experience in ... assets he believes will further the,organization,s reach and ...
Cached Biology Technology:Biopten (Sapropterin Dihydrochloride) Approved by Japanese Ministry of Health for the Treatment of PKU 2Biopten (Sapropterin Dihydrochloride) Approved by Japanese Ministry of Health for the Treatment of PKU 3Biopten (Sapropterin Dihydrochloride) Approved by Japanese Ministry of Health for the Treatment of PKU 4The TPAA Names Mark Oelschlager President 2
... of refrigerated cold traps offers a choice ... volatility/aqueous solvents or high volatility solvents. Ideal ... concentrators/centrifugal evaporators. Also used for maintaining vapor-free ... used in electron microscopes. Can be used ...
96 Well Plate UB, RE bottom; consistent medium binding affinity for hydrophobic complexes and proteins....
Thermo Forma provides an array of accessory Racks for the Cryo/CryoPlus 16" Diameter storage system. To maximise inventory capacity a Jumbo Arrowhead configuration is recommended. You may choose betw...
...
Biology Products: