Navigation Links
Protein key to organ growth

When amounts of a small protein called TCTP (translationally controlled tumor protein) are reduced in the cells of fruit flies, they are smaller than normal, indicating that the protein plays a major role in the growth and proliferation of cells, said researchers at Baylor College of Medicine in a report in current issue of the journal Nature.

Work in his laboratory shows that TCTP plays a role in regulating Rheb (Ras homologue enriched in brain), a protein controlling growth and differentiation, and may give clues to treatment of a particular benign disease called tuberous sclerosis that is associated with the control exerted through the same pathway, said Dr. Kwang-Wook Choi, associate professor of molecular and cellular biology at BCM and his colleagues.

When flies completely lack the protein, they do not live very long. However, when flies have only a little TCTP in their cells, they are very small, said Choi. Graduate student Ya-Chieh Hsu, through a series of studies that concentrated on the effect of the protein on the eyes and wings, elucidated the role of TCTP in the cell.

"She was able to show genetically and biochemically that TCTP is directly involved in regulating Rheb function so that it regulates cell size as well as cell numbers. We found that in the case of dysfunction, the eyes and wings get smaller," said Choi. "If you completely knock out this function in the eye, they have no eyes."

TCTP was of interest because it is over-expressed or overabundant in cancer cells.

"If you reduce the levels of TCTP, tumor cells revert to normal in the laboratory," said Choi. However, in their studies of fruit flies, Choi and his colleagues found when the protein is lacking, it has a profound effect on flies. However, too much does not cause tumor growth. Choi is also a faculty member of the BCM Graduate School of Biomedical Sciences.
'"/>

Source:Baylor College of Medicine


Page: 1

Related biology news :

1. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
2. Protein discovery could unlock the secret to better TB treatment
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. An HIV Protein Plays a Surprising Role in Gene Activation
5. Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease
6. New SARS Protein Linked To Important Cell Doorway
7. The Shapes Of Life: NIGMS Project Yields More Than 1,000 Protein Structures
8. PANTHER Protein Classification System Database 5.0
9. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
10. Newly Discovered Compound Blocks Known Cancer-Causing Protein
11. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Protein key organ growth

(Date:8/29/2014)... Until recently, little has been known about what genetic ... team of scientists, one of whom is a University ... showing that genes controlling the development of the brain ... domestication., The study was published Aug. 28 in ... It is online at http://www.sciencemag.org/ ., The domestication ...
(Date:8/29/2014)... German . ... cycle on Earth and in biological wastewater treatment plants. ... on nitrite as their source of energy. An international ... at the University of Vienna, has now shown that ... of energy. The oxidation of hydrogen with oxygen enables ...
(Date:8/29/2014)... twist them, fold them: modern materials that are light, ... as artificial skin or electronic paper. , Making such ... but a new way of working with copper nanowires ... , Previous success in the field of ultra-lightweight ... precious gold and silver nanowires. , By turning ...
Breaking Biology News(10 mins):New research reveals how wild rabbits were genetically transformed into tame rabbits 2New research reveals how wild rabbits were genetically transformed into tame rabbits 3Hydrogen powers important nitrogen-transforming bacteria 2Hydrogen powers important nitrogen-transforming bacteria 3Copper shines as flexible conductor 2
... years after Columbus, voyage, burning of New World forests and ... decimation of native populations by European diseases. But a new ... fires because both preceded Columbus in many regions worldwide. ... linked previously to the population collapse. We,re saying no, there ...
... Li, MD, PhD, Brigham and Women,s Hospital (BWH) Transplantation Research ... called CD4+ T cells, mature into various subsets of adult ... particular cell surface molecule, known as OX40, is a powerful ... of interleukin-9 (IL-9) (and therefore called TH9 cells) in vitro; ...
... hemiplegia of childhood (AHC) is a very rare disorder ... body and then the other in devastating bouts that ... walking are common among patients with this diagnosis. ... that mutations in one gene cause the disease in ...
Cached Biology News:When the world burned less 2When the world burned less 3When the world burned less 4When the world burned less 5Cell receptor has proclivity for T helper 9 cells, airway inflammation 2Gene discovery set to help with mysterious paralysis of childhood 2Gene discovery set to help with mysterious paralysis of childhood 3
(Date:8/28/2014)... (PRWEB) August 28, 2014 Sterlitech is ... polymeric membranes to its stable of products . ... molecular weight cut-offs and include membrane filters with surface ... increase in customer demand for our membrane process testing ... variety of flat sheet membranes,” explains Sterlitech President Mark ...
(Date:8/28/2014)... (PRWEB) August 28, 2014 A ... around the world is available from Strategic Consulting, ... companies. “ Industrial Microbiology Market Review, Fourth Edition: ... Market ” (IMMR—4) tracks and compares microbiology test ... North America, Europe and Asia, and forecasts future ...
(Date:8/28/2014)... York, NY (PRWEB) August 28, 2014 ... renewed its long term partnership with PTI Inspection ... provide clients with state of the art leak testing ... of the art instruments currently available. As part of ... new High Voltage Leak Detection Instrument developed ...
(Date:8/27/2014)... (PRWEB) August 27, 2014 In ... through Lawrence Livermore National Security LLC ... develop and deliver a state-of-the-art laser system for ... (ELI Beamlines), under construction in the Czech Republic. ... the laser system, called the " High repetition-rate ...
Breaking Biology Technology:Sterlitech Corporation Enhances Its Selection of Flat Sheet Membrane Filters 22 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 22 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 3Whitehouse Labs Renews Partnership with PTI Inspection Systems 2Whitehouse Labs Renews Partnership with PTI Inspection Systems 3LLNL Synchs up with ELI Beamlines on Timing System 2LLNL Synchs up with ELI Beamlines on Timing System 3
... Jan. 3 Cambrex,Corporation (NYSE: CBM ) ... President and Chief Executive Officer, will make a ... on January 8, 2008 at,9:00 a.m. PST at ... (Logo: http://www.newscom.com/cgi-bin/prnh/20000613/CAMBREXLOGO ), A live ...
... Thoratec,Corporation (Nasdaq: THOR ), a world leader ... it will be participating in the JP,Morgan Healthcare ... president and chief executive officer, will provide an,update ... Standard Time (11:30,a.m., Eastern Standard Time)., The ...
... Calif., Jan. 3 /Xinhua-PRNewswire-FirstCall/ --,Kiwa Bio-Tech Products ... its Fertilizer Products in Dingxing, Hebei on ... large volume distribution,businesses in 7 counties in ... agreements were reached with local dealers to ...
Cached Biology Technology:Kiwa Bio-Tech Products Group Holds a Fertilizer Products Exhibition in Hebei 2Kiwa Bio-Tech Products Group Holds a Fertilizer Products Exhibition in Hebei 3