Navigation Links
Protein helps regulate the genes of embryonic stem cells

New research from University of North Carolina at Chapel Hill shows how a protein may be crucial to the regulation of genes in embryonic stem cells. The protein, called "eed," is needed for an essential chemical modification of many genes. Embryos cannot survive without the modification. The findings appear in the May 24 issue of the journal Current Biology.

The research offers an important contribution to a new wave of thinking in genetics: that not all human disease states are due to alterations in DNA sequence. Dr. Terry Magnuson - Sarah Graham Kenan professor, chairman of genetics and director of the Carolina Center for Genome Sciences in UNC's School of Medicine - led the research.

Researchers five decades ago worked to crack the genetic code, the nucleic acid sequence of As, Cs, Gs and Ts making up the DNA of genes. Today, Magnuson's team is trying to unravel a different, newly appreciated mode of inheritance: epigenetics.

"Epigenetic inheritance is heritable information passed down through generations of cells that is not encoded by the DNA sequence," said Nathan D. Montgomery, a graduate student in Magnuson's laboratory and first author of the paper.

This information is in the form of chemical modifications on any of four core histone proteins that group together to provide a molecular scaffold supporting the roughly 35,000 genes in the nucleus of every human cell. Histone modifications affect gene activity and include methylation, in which a methyl component is attached to the histone protein.

The prevailing model is that methylation on histones serves as a docking site for proteins that "read" this histone modification, and it's those proteins that directly have an impact on gene expression - either by activating or silencing a gene.

"Diversity is determined by different types of chemical modifications and also by the number of modifications," Montgomery said. "And those modifications are the unit of epigeneti
'"/>

Source:University of North Carolina School of Medicine


Page: 1 2

Related biology news :

1. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
2. Protein discovery could unlock the secret to better TB treatment
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. An HIV Protein Plays a Surprising Role in Gene Activation
5. Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease
6. New SARS Protein Linked To Important Cell Doorway
7. The Shapes Of Life: NIGMS Project Yields More Than 1,000 Protein Structures
8. PANTHER Protein Classification System Database 5.0
9. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
10. Newly Discovered Compound Blocks Known Cancer-Causing Protein
11. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Protein helps regulate the genes embryonic stem cells

(Date:9/2/2014)... Taiyuan, China, have substantially improved the health of people ... in costs associated with loss of life and disability ... Columbia Center for Children,s Environmental Health (CCCEH) at the ... the Center of Diseases Control and Prevention of Taiyuan ... , The study is the first to document the ...
(Date:9/2/2014)... DURHAM, N.C. -- When you accidentally touch a hot ... know the basic neural circuits involved in sensing and ... out the molecular players. , Duke researchers have made ... molecule involved in pain in worms, and have built ... Sept. 2 in Nature Communications , may help ...
(Date:9/1/2014)... Dietary quality in the U.S. has improved steadily in ... intakebut overall dietary quality remains poor and disparities continue ... a new study from Harvard School of Public Health ... to date that the extensive efforts by many groups ... some payoff, but it also indicates that these efforts ...
Breaking Biology News(10 mins):Clean air halves health costs in Chinese city 2Surprising new role for calcium in sensing pain 2Surprising new role for calcium in sensing pain 3Quality of US diet shows modest improvement, but overall remains poor 2Quality of US diet shows modest improvement, but overall remains poor 3
... what you know often comes at the price of learning ... easy for many, but not for those with conditions such ... simple routines. Using brain scans in monkeys, Duke ... monkeys will switch from exploiting a known resource to exploring ...
... Taylor Chair of Chemistry Barry Dellinger was recently awarded a ... Health Sciences, or NIEHS, to support a Superfund Research Center ... health. It is the only center ever awarded by this ... school of public health. "This grant is the result of ...
... semi-decayed vegetation matter, has been used by commercial growers ... century. Peat is added to potting soil to help ... for peat grew, acres of peat bogs were being ... of extracting peat from wetlands are mounting. And as ...
Cached Biology News:Monkey brains signal the desire to explore 2LSU receives $3.6 million to fund center studying hazardous waste cleanup and health impacts 2For peat's sake: Alternative growing media 2
(Date:8/31/2014)... -- Wockhardt Limited today announces a major boost to ... two of its drugs, WCK 771 and WCK 2349, ... from U.S. Food & Drug Administration (FDA).  QIDP status ... have a high degree of unmet need in their ... (a top U.S. government health and safety body).  QIDP ...
(Date:8/31/2014)... 31, 2014 2014 Market ... a professional and in-depth research report on ... Polyacrylamide information, including Polyacrylamide definition, classification, application, ... industry overview. This research covers the international ... as global industry analysis covering macroeconomic environment ...
(Date:8/30/2014)... 31, 2014 The Global and ... and in-depth study on the current state of ... China. , The report provides a basic overview ... chain structure. Global market analysis and Chinese domestic ... history, developments, trends and competitive landscape of the ...
(Date:8/29/2014)... on electrons, but one of the most promising technologies ... based on light (photons) instead of electrons. First, it ... of single photons and control their direction. Researchers around ... achieve this control, but now scientists at the Niels ... of photons emitted one at a time and in ...
Breaking Biology Technology:U.S. FDA Grants QIDP Status for Wockhardt Anti-Infective Drug Discovery Program 2U.S. FDA Grants QIDP Status for Wockhardt Anti-Infective Drug Discovery Program 3International Polyacrylamide Industry & Copper Iodide Market Data Analysis Now Available at DeepResearchReports.com 2International Polyacrylamide Industry & Copper Iodide Market Data Analysis Now Available at DeepResearchReports.com 3Electrical Insulating Varnish Market World, China Regional Analysis & 2020 Forecasts Available at DeepResearchReports.com 2Electrical Insulating Varnish Market World, China Regional Analysis & 2020 Forecasts Available at DeepResearchReports.com 3Breakthrough in light sources for new quantum technology 2
... 25 /Xinhua-PRNewswire-FirstCall/ -- 3SBio Inc.,(Nasdaq: SSRX ... researching,developing, manufacturing and marketing biopharmaceutical products,primarily in ... with the Chinese,State Food and Drug Administration ... formulation of EPIAO for the treatment of ...
... be Used for Advancement of Cancer Stem Cells and Other ... ... Inc., a privately,held biotechnology company that develops immunotherapeutics to treat,autoimmune disorders, ... in a Series D-2 financing. The round, led by,Nextech Venture, included ...
... COLLINS, Colo., Sept. 24 InVitria,( http://www.InVitria.com ... Annual "Optimizing Cell Culture Development" Conference on,September ... most recent,results optimizing cell culture media using ... ingredients.,( http://www.healthtech.com/ocb/overview.aspx?c=562 ), In a presentation ...
Cached Biology Technology:3SBio Inc. Files for SFDA Approval of High-dose (36,000 IU) EPIAO 23SBio Inc. Files for SFDA Approval of High-dose (36,000 IU) EPIAO 3MacroGenics Raises $25M in Series D-2 Financing 2MacroGenics Raises $25M in Series D-2 Financing 3MacroGenics Raises $25M in Series D-2 Financing 4InVitria Touts Product Advantages at Cambridge's Cell Culture Conference 2