Navigation Links
Protein found to shield pancreatic cancer cells from self-destruction

cases, the result was a drastic reduction of TG2 expression (up to 94 percent) and telltale signs of autophagy in the cancer cells, which became riddled with cavities called vacuoles.

When autophagy occurs, a double membrane forms around a cell organ, or organelle. This autophagosome then merges with a digestive organelle called a lysosome and everything inside is consumed, leaving the vacuole and a residue of digested material. If enough of this happens, the cell dies.

Gabriel Lopez-Berestein, M.D., professor of experimental therapeutics and study co-author, notes that the research also shows that the self-consuming cell death prevented by TG2 is independent of a prominent molecular pathway also known to regulate autophagy called the mammalian target of rapamycin.

"Targeting TG2, or its activating protein PKC, or both, presents a novel and potentially effective approach to treating patients with pancreatic cancer," Lopez-Berestein said. Research in the mouse model remains in the early stages, the researchers caution.

The researchers also show that the TG2 pathway also is separate from another, better known, form of programmed cell death called apoptosis.

Apoptosis, like autophagy, is a normal biological defense mechanism that systematically destroys defective cells by forcing them to kill themselves. In apoptosis, the cells die via damage to their nucleus and DNA, with other cellular organelles preserved. Autophagy kills by degrading those other organelles while sparing the nucleus.

Mehta's lab reported in a Cancer Research paper last September that TG2 overexpression also activates a protein called nuclear factor-kB known to play a role in regulating cell growth, metastasis and apoptosis. This pathway, Mehta explained, could make TG2 an attractive target for other forms of cancer as well.
'"/>

Source:University of Texas M. D. Anderson Cancer Center


Page: 1 2

Related biology news :

1. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
2. Protein discovery could unlock the secret to better TB treatment
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. An HIV Protein Plays a Surprising Role in Gene Activation
5. Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease
6. New SARS Protein Linked To Important Cell Doorway
7. The Shapes Of Life: NIGMS Project Yields More Than 1,000 Protein Structures
8. PANTHER Protein Classification System Database 5.0
9. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
10. Newly Discovered Compound Blocks Known Cancer-Causing Protein
11. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
Post Your Comments:
(Date:12/16/2009)... cells, molecules form an intricate network of interactions. ... measure individual molecular reactions outside the cells. Since ... in the laboratory, scientists suspect that the kinetics ... from external probes. We expected the cellular reaction ... Dieter Braun. "However, our novel optical approach showed ...
(Date:12/16/2009)... for more than 4 billion years before humans showed ... eons more. That suggests they may have something to ... bacteria expert Prof. Eshel Ben-Jacob of the Raymond and ... the study of bacteria, presents compelling evidence to suggest ... not automatically opt for the swine flu H1N1 shot. ...
(Date:12/16/2009)... NEW YORK, Dec. 1 iQor, a global ... in the 2009 InfoWorld 100 Awards Top ... system, TeQ21. This was the first submission for iQor. ... prestigious list of companies," said Vikas Kapoor, president and ... we do business, allowing us to work faster, smarter ...
Breaking Biology News(10 mins):Looking for the heartbeat of cellular networks 2Bacteria wouldn't opt for a swine flu shot 2Bacteria wouldn't opt for a swine flu shot 3iQor Named to InfoWorld 100 List of Top IT Projects of 2009 2VIVUS Announces Pricing of Public Offering of Common Stock 57604 1VIVUS Announces Pricing of Public Offering of Common Stock 57604 2You Gotta Wash Your Hands is the Word Out 21 57601 1You Gotta Wash Your Hands is the Word Out 21 57601 2Extended Antiviral May Benefit Kidney Transplant Patients 57599 1
... nations willing to collectively spend about $1 billion annually could ... of carbon dioxide per year for the next 25 years, ... much money to put an end to a tenth of ... contributors to greenhouse gas emissions, researchers estimate. , If adopted, ...
... renowned scientists from 12 countries including the U.S., Russia, ... fossils, from July 27 to Aug. 2. ... the field of ancient life," said summit organizer J. William ... and Planetary Physics, Center for the Study of Evolution and ...
... and Technology (NIST) have developed a technique to ... protein-based pharmaceuticals. This first systematic study* clarifies the ... their instruments are faithfully measuring the formation of ... impact on quality control and safety in biologic ...
Other Biology News:Paying to save tropical forests could be a way to reduce global carbon emissions 2Paying to save tropical forests could be a way to reduce global carbon emissions 3Paying to save tropical forests could be a way to reduce global carbon emissions 4UCLA 'world summit' to explore ancient life on Earth, and beyond 2NIST trumps the clumps: Making biologic drugs safer 2
(Date:12/17/2009)... in 2010, puts healthcare cost control at the head of the ... , ... New York, NY (Vocus) December 17, 2009 -- ... in 2010, puts healthcare cost control at the ... ahead. , , , , ,“Healthcare typically lags trends in the ...
(Date:12/17/2009)... revamped website from Cleveland-based Life Line Screening allows users to ... screening, learn what to expect at a health screening, share ... Facebook, Twitter, and YouTube. The health screening company’s ... , ... Cleveland, OH (PRWEB) December ...
(Date:12/17/2009)... TOLEDO will be exhibiting the latest particle size distribution technologies, ... Pharmaceutical Scientists’ Annual Meeting, AAPS 2010. , ... ... be exhibiting at the American Association of Pharmaceutical Scientists’ ... 14-18, 2010. Visit Booth 612 at AAPS 2010 to ...
(Date:12/16/2009)... has passed as fact among historians, journalists and politicians, ... the floor of the U.S. Congress: British forces used ... , But that claim has never been fully ... a historian at Colgate University. According to Douglas,s research, ... of Modern History , no such incident ever occurred. ...
Breaking Biology Technology:Squeezing Costs out of Healthcare Tops PricewaterhouseCoopers' List of Health Industry Issues in 2010, 2Squeezing Costs out of Healthcare Tops PricewaterhouseCoopers' List of Health Industry Issues in 2010, 3Squeezing Costs out of Healthcare Tops PricewaterhouseCoopers' List of Health Industry Issues in 2010, 4Squeezing Costs out of Healthcare Tops PricewaterhouseCoopers' List of Health Industry Issues in 2010, 5Website Redesign Enhances Global Health Screening Service's Online Presence 2Website Redesign Enhances Global Health Screening Service's Online Presence 3Particle Size Distribution Technologies at American Association of Pharmaceutical Scientists (AAPS) Annual Meeting 2010 2Despite claims, UK did not gas Iraqis in the 1920s, new research finds 2Despite claims, UK did not gas Iraqis in the 1920s, new research finds 3Despite claims, UK did not gas Iraqis in the 1920s, new research finds 4
... Board: TBIO) announces the following Webcast: , What: ... Conference Call, When: ... Where: http://www.transgenomic.com/events.asp?id=6 , How: ... the address above., ...
... Sigma-Aldrich Corporation (Nasdaq: SIAL ) will be ... Healthcare Conference on Wednesday, May 13th at 2:00 PM Eastern ... listen via live audio broadcast over the Internet available at ... the "Webcast" icon to access this file. About Sigma-Aldrich: ...
... ESTATES, Calif., May 7 The Sixth Annual Healthcare ... Business Innovation (TCBI), will feature the coming together of ... medicine . The Conference will take place ... June 22-23, 2009. Attendees will include a diverse ...
Other Biology Technology:Webcast Alert: Transgenomic Inc. Announces First Quarter 2009 Earnings Release Conference Call Webcast 2Sigma-Aldrich to Present at the Bank of America and Merrill Lynch 2009 Healthcare Conference on Wednesday, May 13, 2009 2Sixth Annual Healthcare Unbound Conference to Focus on Remote Monitoring, Home Telehealth & eHealth for Chronic Care Management & Wellness Promotion 2Sixth Annual Healthcare Unbound Conference to Focus on Remote Monitoring, Home Telehealth & eHealth for Chronic Care Management & Wellness Promotion 3
... pump available in single head (T2-04 SH) or ... in portable air and gas applications. Delivering flow ... in environments where DC operation, high performance, low ... Offers ultra-compact size, long life, and high ...
... and ballscrew technologies, the XRS ... that include all the necessary ... , XY and XYZ ... cabling for power, signals, and ...
... building blocks, Parker can create economical ... that are ideal for pick-and-place and ... Parker can also integrate pneumatic axes, ... ,guarding., Standard or custom configurations ...
Normal Hamster Serum...
Biology Products: