Navigation Links
Protein finding could lead to treatment for inflammatory diseases

A protein that undesirably shields a skin poxvirus from the immune system may become the key ingredient in a new topical treatment for inflammatory diseases, say medical researchers at the University of Illinois at Urbana-Champaign.

In a study appearing this month in the Journal of Virology, the scientists revealed both the function of the protein (MC160) and how it works on a molecular level to inhibit inflammatory responses.

MC160 is so named because it was the 160th gene of the molluscum contagiosum virus (MCV) sequence. "This is a really important protein for a couple of reasons," said Joanna L. Shisler, a professor of microbiology in the U. of I. College of Medicine at Urbana-Champaign who studies poxviruses.

"MC160 first piqued our curiosity because it has a homologue in humans and in herpes viruses, and each of these homologues regulate NF-kappaB" she said. NF-kB is a cellular transcription factor that activates the expression of genes involved in inflammation. Shisler's lab was interested in determining whether MC160 also acted on NF-kB.

In their study -- funded by the National Institutes of Health -- Shisler and Daniel Brian Nichols, a doctoral student in microbiology, treated human embryonic kidney cells with cytokines known to activate NF-kB. Cytokines are chemicals made by immune cells that boost the immune system by stimulating inflammation to fight infectious pathogens.

"We found that the NF-kB levels were always lower in MC160-expressing cells," Shisler said. "This was an exciting new finding because no one had previously found a function for MC160. Currently, Brian and I think that this protein's role is to inhibit NF-kB activation in MCV-infected skin cells, to prevent cytokines from boosting the immune system. MC160 is probably helping the virus persist."

Upon further examination, Shisler and Nichols discovered that MC160 shuts down the NF-kB-triggered inflammatory response by degrading a subunit of t
'"/>

Source:University of Illinois at Urbana-Champaign


Page: 1 2 3

Related biology news :

1. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
2. Protein discovery could unlock the secret to better TB treatment
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. An HIV Protein Plays a Surprising Role in Gene Activation
5. Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease
6. New SARS Protein Linked To Important Cell Doorway
7. The Shapes Of Life: NIGMS Project Yields More Than 1,000 Protein Structures
8. PANTHER Protein Classification System Database 5.0
9. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
10. Newly Discovered Compound Blocks Known Cancer-Causing Protein
11. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Protein finding could lead treatment for inflammatory diseases

(Date:4/1/2015)... Medisafe ™, the leading global medication management platform with ... Android smartphones and tablets, announces today that ... allow patients to track and correlate their adherence directly ... be able to visualize in real-time how taking medication ... glucose levels and blood pressure. "Patients need ...
(Date:3/31/2015)... NEW YORK , March 31, 2015   ... announced the launch of the Post-Surgical Pain Management TRACKER, ... data products tracking usage trends in the medical device ... monthly access to data including treatment volumes, market share, ... manage the pain associated with joint surgery. ...
(Date:3/26/2015)... March 26, 2015 The Granite ... recreation and athletic club, today announced it has implemented ... freedom of movement for members and staff, while restricting ... comprehensive process, we selected FST,s IMID Access system because ... for our members and staff, in addition to unparalleled ...
Breaking Biology News(10 mins):Medisafe Announces Launch of Biometric Integration, Enabling Patients to Stay Adherent to Their Meds and See Tangible Health Results 2Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2
... Scientists at The Scripps Research Institute have discovered that ... schizophrenic subjects. The findings suggest that drugs already ... a treatment for schizophrenia and related conditions in the elderly. ... Nature journal, Translational Psychiatry , shows the ...
... of many serious diseases such as cancer, Alzheimer,s, arteriosclerosis ... to excessive amounts of electrically charged, aggressive oxygen compounds. ... processes, but also in the case of ongoing stress, ... stress is too high, it overwhelms the body,s natural ...
... fish crawling on stumpy limbs from a shrinking desert ... a leading theory for the evolutionary transition between fish ... adaptation to changing environmental conditions, however, may, itself, be ... Oregon scientist Gregory J. Retallack, professor of geological sciences, ...
Cached Biology News:Scripps Research scientists discover a brain cell malfunction in schizophrenia 2Scripps Research scientists discover a brain cell malfunction in schizophrenia 3Scripps Research scientists discover a brain cell malfunction in schizophrenia 4A new theory emerges for where some fish became 4-limbed creatures 2
(Date:5/4/2015)... - New Massive Open Online Course (MOOC) ... United States Medical Licensing Examination Elsevier ... information products and services, announced today that it has ... to help medical students prepare for the United States ... most daunting of the three exams medical students must ...
(Date:5/4/2015)... 2015   Intrexon Corporation (NYSE: XON ... financial results after the market closes on May 11, ... day at 5:30 PM ET to discuss the results ... conference call may be accessed by dialing 1-888-346-3959 (Domestic ... "Intrexon Conference Call."  Participants may also access the live ...
(Date:5/4/2015)... Illinois (PRWEB) May 04, 2015 ... options for patients with arm and hand impairments ... exoskeleton at its Oakbrook Terrace network site. , ... the Armeo®Spring is a highly-regarded treatment option for ... acquiring the Armeo®Spring, Marianjoy becomes one of just ...
(Date:5/1/2015)... (PRWEB) May 01, 2015 OncoTAb, ... (UNC Charlotte) spin-out company, announced that Pinku Mukherjee, Ph.D. ... the UNC Board of Governors’ highest faculty honor. Mukherjee ... humanity’s welfare , for her innovative research and development ... Gardner Award represents a crowning moment in my scientific ...
Breaking Biology Technology:Elsevier's Free MOOC Prepares Med Students for Licensing Exam 2Elsevier's Free MOOC Prepares Med Students for Licensing Exam 3Intrexon to Announce First Quarter 2015 Financial Results on Monday, May 11, 2015 2Marianjoy Acquires Armeo®Spring Arm and Hand Rehabilitation Exoskeleton at Oakbrook Terrace Facility 2OncoTAb CSO Awarded the University of North Carolina’s O. Max Gardner Award 2
... Volker Wippersteg, Katja Kapp, Werner Kunz, ... D-40225 Dsseldorf, Germany, , , ... Schistosomes are parasitic helminths that cause ... a tropical disease of worldwide significance (Savioli et al.1997). , ...
... Peter M Kilby, Roche Discovery Welwyn, 40 Broadwater Road, Welwyn , ... Syngenta, Jealotts Hill International Research Centre, Bracknell, Berkshire, , ... , Abstract , ... (Figure 1) for , running 2-D SDS-PAGE slab gels ...
... Jacqueline Boultwood, Gail M. Abrahamson, and J.,S. Wainscoat, Leukemia Research Fund, ... Kingdom , , ... Tumor diagnoses, DNA fingerprinting, ... For,example, peripheral blood may be used as a source from solid,tumors, ...
Cached Biology Technology:Biolistic Gene Transfer to Generate Transgenic Schistosomes, Rev A 2Biolistic Gene Transfer to Generate Transgenic Schistosomes, Rev A 3Biolistic Gene Transfer to Generate Transgenic Schistosomes, Rev A 4Biolistic Gene Transfer to Generate Transgenic Schistosomes, Rev A 5Biolistic Gene Transfer to Generate Transgenic Schistosomes, Rev A 6Biolistic Gene Transfer to Generate Transgenic Schistosomes, Rev A 7Biolistic Gene Transfer to Generate Transgenic Schistosomes, Rev A 8Biolistic Gene Transfer to Generate Transgenic Schistosomes, Rev A 9Use of the PROTEAN Plus Dodeca Cell for Second-Dimension SDS-PAGE, Rev A 2Use of the PROTEAN Plus Dodeca Cell for Second-Dimension SDS-PAGE, Rev A 3Use of the PROTEAN Plus Dodeca Cell for Second-Dimension SDS-PAGE, Rev A 4Use of the PROTEAN Plus Dodeca Cell for Second-Dimension SDS-PAGE, Rev A 5PFGE Analysis of Chromosomal DNA From a Single Hair Root 2
...
... The Mini-PROTEAN II multiscreen apparatus is used to ... cm) gels. The apparatus can screen up to ... cut the blot into strips. The apparatus includes ... that accommodate one or two 8 x 7 ...
Fingerprinting II database sharing tools is an optional module for the Fingerprinting II Basic software package that enables peer-to-peer data exchange over the internet and provides external databas...
... II Informatix dimensioning ... optional module that ... analysis, multidimensional scaling, ... MANOVA, and self-organizing ...
Biology Products: