Navigation Links
Protein discovery targets antibiotic-resistant bacteria

A new type of protein discovered by Queen’s University researchers may be useful in developing treatments for antibiotic-resistant bacteria, such as those that cause food poisoning and typhoid.

By solving the structure and activity of the protein ?called YihE or RdoA ?a team of professors and students from the departments of Biochemistry and Microbiology & Immunology has opened up possibilities for new drug development.

“Our group is the first to solve the structure and to begin to understand the function of this particular protein,?says Dr. Nancy Martin (Microbiology & Immunology), who coordinated the study with Dr. Zongchao Jia (Biochemistry). “It turns out to be a potentially good target in a wide range of bacteria that cause infectious diseases.?Because of the increasing number of antibiotic-resistant strains of many different types of bacteria, such as salmonella, she notes, new approaches to antibiotic therapy are needed.

The Queen’s findings are published in the on-line edition of the journal Molecular Microbiology. Also on the team, from Biochemistry, are PhD student Jimin Zheng and post-doctoral fellow Vinay Singh; and Microbiology & Immunology Master’s student Chunhua He.

The group is studying sensory pathways used by bacteria that enter our bodies and move from the stomach into the gastro-intestinal tract. “If we can block the sensory pathway, then the bacteria can’t adapt to that change in their environment, and won’t be able to infect,?says Dr. Martin.

In North America, the people treated for food poisoning with drugs tend to be elderly or “immune compromised?where there is a need for antibiotics to clear the infection. Since the organism that causes salmonellosis is related to that responsible for typhoid fever ?a huge problem in less developed countries ?the model being developed at Queen’s could potentially be a target for treating typhoid as well. The underlying goal is to control, if not clear, the infection.

“It’s basic science that we are doing, but we’re using that as a foundation for trying to develop approaches that will have positive impacts on human health,?says Dr. Martin.
'"/>

Source:Queen's University


Related biology news :

1. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
2. Protein discovery could unlock the secret to better TB treatment
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. An HIV Protein Plays a Surprising Role in Gene Activation
5. Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease
6. New SARS Protein Linked To Important Cell Doorway
7. The Shapes Of Life: NIGMS Project Yields More Than 1,000 Protein Structures
8. PANTHER Protein Classification System Database 5.0
9. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
10. Newly Discovered Compound Blocks Known Cancer-Causing Protein
11. UF Researchers Map Bacterial Proteins That Cause Tooth Loss

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2016)... --  EyeLock LLC , a market leader of iris-based ... IoT Center of Excellence in Austin, Texas ... embedded iris biometric applications. EyeLock,s iris authentication ... with unmatched biometric accuracy, making it the most proven ... platform uses video technology to deliver a fast and ...
(Date:4/28/2016)... , April 28, 2016 Infosys ... (NYSE: INFY ), and Samsung SDS, a global ... that will provide end customers with a more secure, fast ...      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ) , ... but it also plays a fundamental part in enabling and ...
(Date:4/19/2016)... UAE, April 20, 2016 The ... as a compact web-based "all-in-one" system solution for all ... fingerprint reader or the door interface with integration authorization ... access control systems. The minimal dimensions of the access ... into the building installations offer considerable freedom of design ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... 2016  Liquid Biotech USA ... a Sponsored Research Agreement with The University of ... from cancer patients.  The funding will be used ... with clinical outcomes in cancer patients undergoing a ... be employed to support the design of a ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... While the ... such as the Cary 5000 and the 6000i models are higher end machines that ... the height of the spectrophotometer’s light beam from the bottom of the cuvette holder. ...
(Date:6/23/2016)... , June 23, 2016   Boston Biomedical ... novel compounds designed to target cancer stemness pathways, ... been granted Orphan Drug Designation from the U.S. ... of gastric cancer, including gastroesophageal junction (GEJ) cancer. ... designed to inhibit cancer stemness pathways by targeting ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... YM (Yeast and Mold) microbial test has received AOAC Research Institute approval 061601. ... microbial tests introduced last year,” stated Bob Salter, Vice President of Regulatory and ...
Breaking Biology Technology: