Navigation Links
Protein averts cell suicide but might contribute to cancer

research, Fiala developed a new way to sequence very short lengths of DNA. "This allowed us to pin down exactly what mistakes Dpo4 makes," he says.

The findings reveal why the enzyme makes mistakes.

DNA resembles a spiral staircase that is made from separate halves, with half-steps protruding from each. The half-steps fit together down the center to form the complete staircase.

In DNA, the half-steps are known as the bases ?the ‘A's, ‘C's, ‘G's and ‘T's ?that run the length of a DNA helix. A complete step is formed by pairs of bases according to a rule: ‘A' always pairs with ‘T,' and ‘C' always pairs with ‘G.'

When cells make new DNA, the two strands separate, and each old half becomes a template for a new partner. The DNA-making machinery travels along the old half, building the new half according to the bases it finds on the old half. When it meets an ‘A' on the old half, it pairs it with a ‘T' on the new half (and vice versa); when it meets a ‘G' on the old half, it pairs it with a ‘C' on the new strand. In the end, there are two complete DNA molecules instead of one, each made up of an old half and a new half.

But trouble arises during the building if one of the bases ?one of the half steps ?is missing. When the DNA replication machine encounters the gap, it stalls. If the standstill continues, the cell will self-destruct.

It's at this point when Dpo4 jumps in. It adds a base opposite the gap and then leaves, allowing the DNA-making machinery to bypass the damage and continue construction.

The action averts cell suicide, but the gap ?and the stop-gap base ?might become a mutation that, in conjunction with later genetic damage, causes the cell to eventually become cancerous.

"The objective of this enzyme is to allow replication to continue, not to repair the damage," says Fiala. The damage will persist, and cells might try to repair it later. But as long as DNA replication can
'"/>

Source:Ohio State University


Page: 1 2 3

Related biology news :

1. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
2. Protein discovery could unlock the secret to better TB treatment
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. An HIV Protein Plays a Surprising Role in Gene Activation
5. Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease
6. New SARS Protein Linked To Important Cell Doorway
7. The Shapes Of Life: NIGMS Project Yields More Than 1,000 Protein Structures
8. PANTHER Protein Classification System Database 5.0
9. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
10. Newly Discovered Compound Blocks Known Cancer-Causing Protein
11. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Protein averts cell suicide but might contribute cancer

(Date:3/24/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/hdgz7h/global_iris ) has ... Market 2015-2019" report to their offering. ... grow at a CAGR of 23.5 percent over the ... scenario and the growth prospects of the Global Iris ... market size, the report considers the revenue generated from ...
(Date:3/23/2015)... March 23, 2015   HOYOS Labs , a ... today announced that the Company will demonstrate multiple biometrics-based ... and consumers at Connect:ID on March 23 through 25, ... Labs will highlight the IEEE Biometric Open Protocol Standard; ... and enterprise access control system. BOPS was invented by ...
(Date:3/20/2015)... OXFORD, Conn. , March 20, 2015 ... "Company"), a biometric authentication company focused on the growing ... Wocket® smart wallet is one of the products featured ... today, March 20th at 11:00 PM EST on the ... travels to Las Vegas , site ...
Breaking Biology News(10 mins):Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 2NXT-ID's Wocket Biometric Smart Wallet to Air on "I Want That" International CES Special 3
... Medical Center clinical researchers will present findings about a ... Francisco at the Interscience Conference on Antimicrobial Agents and ... research team is presenting data in two poster presentations ... killing 99.9 percent of infectious airborne germs. Findings from ...
... to newly placed sod may result in nutrient runoff into ... to apply fertilizer and what kind is the best for ... team of scientists from Texas A&M AgriLife Research: Dr. Jacqui ... Ben Wherley, assistant professor of turfgrass science and ecology; Dr. ...
... principal cause of global warming? A new study by two ... keeps sea urchins in check will in turn allow kelp forests to ... amount of CO 2 from the atmosphere than if it were ... theory is outlined in a paper released online today (September 7, 2012) ...
Cached Biology News:Research finds novel airborne germ-killing oral spray effective in fighting colds and flu 2Turf study to monitor runoff, establish fertilizer management practices 2UC Santa Cruz study shows how sea otters can reduce CO2 in the atmosphere 2
(Date:4/30/2015)... (PRWEB) April 30, 2015 Clinovo ... 2015 PharmaSUG Annual Conference held in Orlando, FL ... Staffing Solutions along with Leslie Kolman, Manager of Staffing ... latest Clinovo news at Booth #17. , “We ... Conference again this year”, Says Trisha Heredia, Senior Director ...
(Date:4/29/2015)... USA (PRWEB) April 29, 2015 ... sensing, and imaging on the East Coast, reaffirmed its ... managers, researchers, applications developers, and industry suppliers to meet ... imaging for multiple applications. , The event included 55 ... commercial and scientific sensing and imaging -- and an ...
(Date:4/29/2015)... N.J. , April 29, 2015 Cambrex Corporation ... results will be released on Friday, May 1, 2015 before ... The Company will host a conference call to ... When: , Friday, May 1, ... , 1-888-468-2440 for U.S.1-719-325-2454 for International  Passcode:  7993632 ...
(Date:4/29/2015)... Gene therapy can clip out genetic material ... gene in human cardiac cells, according to a study led ... of Medicine at Mount Sinai. The study is published in ... mutations, the small random, changes in the genetic code making ... seen in patients with heart failure,” says Roger J. Hajjar, ...
Breaking Biology Technology:Clinovo Exhibits at the 2015 PharmaSUG Annual Conference on May 17-20th in Orlando, FL 2Clinovo Exhibits at the 2015 PharmaSUG Annual Conference on May 17-20th in Orlando, FL 3SPIE DSS provides venue for collaboration vital to research, applications advances 2SPIE DSS provides venue for collaboration vital to research, applications advances 3SPIE DSS provides venue for collaboration vital to research, applications advances 4Gene Therapy Clips Out Heart Failure Causing Gene Mutations 2Gene Therapy Clips Out Heart Failure Causing Gene Mutations 3Gene Therapy Clips Out Heart Failure Causing Gene Mutations 4
... Jan. 24 Quintiles,Transnational Corp. today announced the ... support the company,s continued,growth under the leadership of ... and the management team. Gillings and global private,investment ... the lead,investors in Quintiles, with 3i also becoming ...
... of chemistry and biochemistry at The University of Texas ... Chemistry jointly with Professor William Moerner of Stanford University. ... Professor Yuli Tamir, was given to the two scientists ... single-molecule spectroscopy and imaging. , The $100,000 prize will ...
... ... - Non-GAAP Diluted EPS Up 15%, GAAP Diluted ... VARI) today reported first quarter 2008 revenues of $237.4,million, representing an increase ... year 2007. The increase was broad-based,with growth in sales of products for ...
Cached Biology Technology:Quintiles Completes Previously Announced New Investor Partnership, Co-Led by Founder, Chairman and CEO Dennis Gillings, Bain Capital, TPG and 3i 2Quintiles Completes Previously Announced New Investor Partnership, Co-Led by Founder, Chairman and CEO Dennis Gillings, Bain Capital, TPG and 3i 3Varian, Inc. Reports First Quarter 2008 Results 2Varian, Inc. Reports First Quarter 2008 Results 3Varian, Inc. Reports First Quarter 2008 Results 4Varian, Inc. Reports First Quarter 2008 Results 5Varian, Inc. Reports First Quarter 2008 Results 6Varian, Inc. Reports First Quarter 2008 Results 7Varian, Inc. Reports First Quarter 2008 Results 8Varian, Inc. Reports First Quarter 2008 Results 9Varian, Inc. Reports First Quarter 2008 Results 10Varian, Inc. Reports First Quarter 2008 Results 11Varian, Inc. Reports First Quarter 2008 Results 12Varian, Inc. Reports First Quarter 2008 Results 13Varian, Inc. Reports First Quarter 2008 Results 14Varian, Inc. Reports First Quarter 2008 Results 15Varian, Inc. Reports First Quarter 2008 Results 16Varian, Inc. Reports First Quarter 2008 Results 17Varian, Inc. Reports First Quarter 2008 Results 18
B-FABP (FL-132)...
... Phosphatase ( l-PPase) is ... with activity towards phosphorylated ... residues. It is the ... the ORF221 open reading ...
... Innovative HL-2000 HybriLinker combines the benefits of a ... self-contained, space saving unit. , ... Laboratory allows crosslinking ,and hybridization at one location ... HL-2000 operate independently of each other , ...
... traps a wide variety of solvent vapors that ... glass condensation flask (GCF400) allows for the collection ... easy draining. Rapid cooling time minimizes waiting period., ... quick solvent changes , -50?C ...
Biology Products: