Navigation Links
Protein averts cell suicide but might contribute to cancer

research, Fiala developed a new way to sequence very short lengths of DNA. "This allowed us to pin down exactly what mistakes Dpo4 makes," he says.

The findings reveal why the enzyme makes mistakes.

DNA resembles a spiral staircase that is made from separate halves, with half-steps protruding from each. The half-steps fit together down the center to form the complete staircase.

In DNA, the half-steps are known as the bases ?the ‘A's, ‘C's, ‘G's and ‘T's ?that run the length of a DNA helix. A complete step is formed by pairs of bases according to a rule: ‘A' always pairs with ‘T,' and ‘C' always pairs with ‘G.'

When cells make new DNA, the two strands separate, and each old half becomes a template for a new partner. The DNA-making machinery travels along the old half, building the new half according to the bases it finds on the old half. When it meets an ‘A' on the old half, it pairs it with a ‘T' on the new half (and vice versa); when it meets a ‘G' on the old half, it pairs it with a ‘C' on the new strand. In the end, there are two complete DNA molecules instead of one, each made up of an old half and a new half.

But trouble arises during the building if one of the bases ?one of the half steps ?is missing. When the DNA replication machine encounters the gap, it stalls. If the standstill continues, the cell will self-destruct.

It's at this point when Dpo4 jumps in. It adds a base opposite the gap and then leaves, allowing the DNA-making machinery to bypass the damage and continue construction.

The action averts cell suicide, but the gap ?and the stop-gap base ?might become a mutation that, in conjunction with later genetic damage, causes the cell to eventually become cancerous.

"The objective of this enzyme is to allow replication to continue, not to repair the damage," says Fiala. The damage will persist, and cells might try to repair it later. But as long as DNA replication can
'"/>

Source:Ohio State University


Page: 1 2 3

Related biology news :

1. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
2. Protein discovery could unlock the secret to better TB treatment
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. An HIV Protein Plays a Surprising Role in Gene Activation
5. Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease
6. New SARS Protein Linked To Important Cell Doorway
7. The Shapes Of Life: NIGMS Project Yields More Than 1,000 Protein Structures
8. PANTHER Protein Classification System Database 5.0
9. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
10. Newly Discovered Compound Blocks Known Cancer-Causing Protein
11. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Protein averts cell suicide but might contribute cancer

(Date:12/15/2014)... 12, 2014 Research and Markets ... the "Global Facial Recognition Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 Facial recognition is ... Facial recognition system measures the overall facial feature ... mouth, and the distance between eyes. Facial recognition ...
(Date:12/10/2014)... NEW YORK , Dec. 8, 2014 You,ve ... online banking account but can,t remember your password, site key ... birthday? Who was your first grade teacher? ... launches the app that will finally put an ... PINs – 1U TM . 1U leverages a ...
(Date:12/10/2014)...     Jifflenow ...   Jifflenow, a leading provider ... business-to-business (B2B) events, today announced a partnership with ... communication (NFC), Bluetooth low energy (BLE), and cloud-based ... Jifflenow will integrate its meeting scheduling ...
Breaking Biology News(10 mins):Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3
... North America are under attack. Since 2006, more than a ... them, because there has not been enough evidence to implicate ... the fungus Geomyces destructans is the causal agent of White-nose ... The study is coauthored by Justin Boyles, a post-doctoral research ...
... from the stomach and covers the intestines provides nutrients that ... research team based at the University of Chicago in the ... Ovarian cancer, the fifth leading cause of cancer deaths ... opposed to distant organs. In 80 percent of women, by ...
... at a school beside an informal electronic waste salvage ... lead, cadmium and other health-threatening pollutants over 50 times ... church headquarters and a soccer field are likewise polluted ... metal site, where electronic trash is scavenged for valuable ...
Cached Biology News:UT scientist helps confirm link between fungus and bat epidemic 2Fat cells in abdomen fuel spread of ovarian cancer 2High toxic levels found at school, market neighboring informal e-waste salvage site in Africa 2High toxic levels found at school, market neighboring informal e-waste salvage site in Africa 3High toxic levels found at school, market neighboring informal e-waste salvage site in Africa 4High toxic levels found at school, market neighboring informal e-waste salvage site in Africa 5
(Date:12/22/2014)... (PRWEB) December 22, 2014 Fertility Associates ... Donor Egg Bank USA , a network of more ... Through this partnership, patients have fast access to a ... vitro fertilization, IVF . Fertility Associates of Memphis is ... this fertility treatment option. , Dr. William Kutteh ...
(Date:12/19/2014)... Charm Sciences is pleased to announce that its ... M1 in raw commingled milk is the first lateral ... peer reviewed report of the validation by Technology and ... Fisheries Research (ILVO-T&V) has been published by the Taylor ... toxic aflatoxin and a known carcinogen, can be passed ...
(Date:12/19/2014)... Ill. , Dec. 19, 2014 Naurex ... develop novel drugs for diseases of the central nervous ... president and chief executive officer, will present at the ... Riedel,s presentation will take place at 3:00 p.m. PST ... Francis in San Francisco, Calif. ...
(Date:12/19/2014)... Calif. , Dec. 19, 2014 Bina Technologies, ... USA) announced today that they have been acquired by ... is a privately held company that provides a ... next generation sequencing (NGS) data for the academic and ... Roche Sequencing Unit, and will continue to focus on ...
Breaking Biology Technology:Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2Naurex to Present at 33rd Annual J.P. Morgan Healthcare Conference 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... For the second consecutive year, the City ... most digitized and online-accessible municipalities in the country. , ,In ... Digital Government , a national research and advisory institute on ... honored the city as the top user of technology in ...
... Internet symposium presented last week at the Milwaukee ... as impressive as their messages. , ,Mary Glass ... and is championing the issue for Milwaukee neighborhoods, delivered ... give everyone the critical opportunity to take advantage of ...
... doesn't even have a patent and she's excited about the ... ,Sieber-Blum, a professor of cell biology, neurobiology, and anatomy at ... team that has applied for a patent on its work ... a new type of adult stem cell that appears to ...
Cached Biology Technology:Handicapping Milwaukee's wireless initiative 2Handicapping Milwaukee's wireless initiative 3Handicapping Milwaukee's wireless initiative 4Handicapping Milwaukee's wireless initiative 5Researcher wants to commercialize adult stem cell discovery 2Researcher wants to commercialize adult stem cell discovery 3
... 10X BlueJuice Gel ... for easy loading and ... in agarose or native ... buffer features higher density ...
... Immunogen: Synthetic peptide derived ... JAB1 (Jun activation domain-binding protein ... for the JAB1 protein. ... Jurkat cell lysates). Applications: ...
... TOPO Cloning is ... available for cloning PCR ... and Zero Blunt TOPO ... and activated with topoisomerase ...
... Antibody Production Conjugated peptides or ... ten-week protocol to produce antibodies in 2 rabbits. ... antiserum) ELISA test until the titer reaches ... target titer Protein G purification Antibodies ...
Biology Products: