Navigation Links
Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease

It's all in the packaging. How nature wraps and tags genes determines if and when they become active, according to researchers from Harvard and the Massachusetts Institute of Technology (M.I.T.). They did the largest, most detailed study to date of the protein structure that surrounds the human genome.

Their findings reveal surprising and previously unknown specifics of how genes get switched on during development of the human body and in diseases such as cancer.

"Each type of cell in our bodies contains the same genes. What makes them do different things involves which genes are turned on," notes Bradley Bernstein, a pathologist at Harvard Medical School. He is also a research associate at the Broad Institute of Harvard and M.I.T., where a complex analysis of packaging of two entire human chromosomes was done for the first time.

Besides Bernstein, the investigators included Morris Loeb Professor of Chemistry Stuart Schreiber; Michael Kamal, Eric Lander, and others at the Broad Institute; and their colleagues from Affymetrix, a California technology company.

The analysis shows a striking and surprising exception in the way some critical genes are activated by the protein packaging. These proteins act like spools for the long strings of DNA that contain our genes and form chromosomes. The researchers studied chemical tags that are attached to the spools and switch on the genes they wrap. In most cases, they found these tags turn genes on and off individually. The big surprise involves clusters of so-called "HOX" genes, which apparently work in concert to control how we develop in the womb. Instead of being activated individually like most genes, the HOX genes appear to be turned on in groups by massive numbers of tags.

HOX genes also are deeply involved in cancer, making the findings particularly important. Some of the proteins that regulate HOX genes are capable of causing or suppressing tumors.

Technological breakthrou
'"/>

Source:Harvard University


Page: 1 2 3

Related biology news :

1. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
2. Protein discovery could unlock the secret to better TB treatment
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. An HIV Protein Plays a Surprising Role in Gene Activation
5. New SARS Protein Linked To Important Cell Doorway
6. The Shapes Of Life: NIGMS Project Yields More Than 1,000 Protein Structures
7. PANTHER Protein Classification System Database 5.0
8. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
9. Newly Discovered Compound Blocks Known Cancer-Causing Protein
10. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
11. Protein offers way to stop microscopic parasites in their tracks
Post Your Comments:
(Date:12/10/2014)... NEW YORK , Dec. 8, 2014 You,ve ... online banking account but can,t remember your password, site key ... birthday? Who was your first grade teacher? ... launches the app that will finally put an ... PINs – 1U TM . 1U leverages a ...
(Date:12/10/2014)... Dec. 08, 2014 Research and Markets ... of the "Biometrics Market in Japan 2014-2018" ... http://photos.prnewswire.com/prnh/20130307/600769 The integration ... as rural banking and upgradation of the driver,s ... in the market. Besides the aforementioned projects, biometrics ...
(Date:12/4/2014)... PALM BEACH GARDENS, Fla. , Dec. 3, ... identity management solutions, today announced that its DigitalPersona ... 4500 fingerprint readers have been deployed throughout ... Carolina , South Carolina ... network headquartered in Southern Pines, North ...
Breaking Biology News(10 mins):The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3
... the University of Leeds, has found that a common ... monoxide poisoning. Animal studies have shown that the ... deaths from arrhythmias irregular or abnormally paced heartbeats ... The findings could have important implications for the development ...
... August 6, 2012 Individuals with mutations in BRCA1 and ... and ovarian cancers. Families at risk have been seeking ... but the standard method of direct sequencing is labor-intensive, costly, ... BRCA2 genes. A group of Canadian scientists has developed ...
... is able to source food from the land as well as ... University of London has found. Scientists analysed the behaviour of ... the water level of the lake was low, the crayfish found ... journal PLoS ONE today (3 August 2012). Lead ...
Cached Biology News:Anti-angina drug shows protective effects from carbon monoxide 2Anti-angina drug shows protective effects from carbon monoxide 3New method provides fast, accurate, low cost analysis of BRCA gene mutations in breast cancer 2Crayfish species proves to be the ultimate survivor 2
(Date:12/24/2014)... On Friday, December 19, 2014, President ... and Continuing Resolution Appropriations Act of 2015, which ... eligible to receive funding through the Congressionally Directed ... of Defense (DoD). The Hydrocephalus Association (HA), working ... is celebrating this victory for the over 1 ...
(Date:12/24/2014)... CA (PRWEB) December 23, 2014 Pipette.com ... where their Twitter followers can submit their #HolidayInTheLab pictures ... and their lab mates. , For those struggling to ... mates, the Pipette.com Holiday in the Lab Contest provides ... Pipette.com Twitter followers to send pictures of their ...
(Date:12/24/2014)... -- Rock Creek Pharmaceuticals, Inc., (NASDAQ: RCPI ) ... Application (CTA) with the United Kingdom,s ... approval to initiate clinical trials for the continued development ... on the Company receiving CTA regulatory approval, the Company ... the safety, tolerability and dose escalation of Anatabine Citrate ...
(Date:12/22/2014)... HILL, N.C. , Dec. 22, 2014 /PRNewswire/ ... today announced that it has signed a letter ... company that has developed and patented a nanotechnology-based ... medical diagnostics products that enable rapid on-site collection ... alcohol use/abuse and health issues in an immediate, ...
Breaking Biology Technology:Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2Major Pipette Distributor Pipette.com Announces their Holiday in the Lab Contest 2Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 2Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 3ALNE Announces Intention To Acquire BioTechPharma 2
... ... has linked a developmental checkpoint in the differentiation of hematopoietic progenitors into specific T cell ... this week, the discovery lends support to a new model for the development of blood ... (PRWeb UK) ...
... Mass. , July 1 X-Chem, Inc. ... with Roche to apply X-Chem,s proprietary platform to the ... high-value therapeutic targets. As part of the agreement, Roche ... discovery milestones, and technology access fees. Roche will have ...
... June 30 RSB Spine, LLC, a medical device company ... disc disease, today announced a 50% sales increase for the second quarter ... the company reported record sales for the month of June. , ... RSB Spine Chief Executive Officer ...
Cached Biology Technology:The Last Checkpoint to T Cell Fate 2X-Chem and Roche Enter Into Drug Discovery Collaboration and License Agreement 2
... DNA Engine Opticon 2 real-time PCR detection ... for fluorescence excitation (470-505 nm) and two ... 540-700 nm). The Opticon 2 system is ... which includes a thermal gradient feature. This ...
Fingerprinting II Basic software is used for analyzing fingerprint sample types (electrophoretic gels, HPLC and other chromatographic patterns, spectrophotometric and densitometric curves)....
Fingerprinting II database sharing tools is an optional module for the Fingerprinting II Basic software package that enables peer-to-peer data exchange over the internet and provides external databas...
... identification and library manager ... that adds capabilities for ... identification of unknowns against ... of the same taxon ...
Biology Products: