Navigation Links
Protein Discovery Could Unlock The Secret To Better TB Treatment

UCL scientists have found a protein that could unlock the secret to quicker, more effective treatment of TB by waking TB bacteria in the body. Once the TB bacteria are active again, the disease becomes treatable using common drugs like antibiotics. Scientists believe that uncovering the molecular structure of this protein will lead the way to designing drugs which enable treatment of dormant and multidrug resistant TB.

In England and Wales around 400 people die each year from the disease. The top challenge for TB control in the European region is multidrug-resistant TB (MDR-TB). Eight per cent of the bacteria causing TB in patients are resistant to one or more drugs and one per cent show multidrug resistance. Left untreated, a person with infectious TB of the lungs infects around 10 to 15 people every year.

In a study published on 1st March 2005 in Nature Structural & Molecular Biology, a combined team discovered the structure of a protein known as resuscitation promoting factor (Rpf). Five versions of the Rpf protein exist in TB bacteria. The paper's unveiling of the molecular structure of Rpf could be crucial to the treatment of TB in the future.

Dr John Ward, Dept of Biochemistry and Molecular Biology at UCL, said: "The discovery of Rpf in the TB bacteria could allow the development of methods to 'wake-up' all dormant bacteria in a patient allowing antibiotics to kill the bacteria and cure the disease."

The team includes Prof Brian Henderson at the UCL Eastman Dental Institute, Nicholas Keep from Birkbeck, University of London, and John Ward at UCL as well as researchers from INSERM Montpellier.


'"/>

Source:University College London


Page: 1

Related biology news :

1. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
2. Protein discovery could unlock the secret to better TB treatment
3. Researchers Uncover Key Step In Manufacture of Memory Protein
4. An HIV Protein Plays a Surprising Role in Gene Activation
5. Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease
6. New SARS Protein Linked To Important Cell Doorway
7. The Shapes Of Life: NIGMS Project Yields More Than 1,000 Protein Structures
8. PANTHER Protein Classification System Database 5.0
9. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
10. Newly Discovered Compound Blocks Known Cancer-Causing Protein
11. UF Researchers Map Bacterial Proteins That Cause Tooth Loss
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Protein Discovery Could Unlock The Secret Better Treatment

(Date:7/9/2014)... children with traumatic injuries have identified an immune ... develop a hospital-acquired infection. The study, led by ... in June in the journal Shock , ... lead to the clinical implementation of quick-turnaround immune ... immune system damage following critical illness or injury ...
(Date:7/9/2014)... Ill. With over 100 diseases that can attack ... top of the most wanted list? University of Illinois ... that more research is needed on the fungus that ... with cool, damp growing conditions but Macrophomina phaseolina ... and dry drought conditions. , "As the climate continues ...
(Date:7/9/2014)... Adlie penguins shows that the population is 3.79 ... previously estimated. Adlie penguins have long been considered ... the effects of climate change and fishing in ... imagery, researchers from Stony Brook University and University ... permits regular monitoring of Adlie penguins across their ...
Breaking Biology News(10 mins):Immune function predicts infection risk among child trauma patients 2Immune function predicts infection risk among child trauma patients 3Climate change provides good growing conditions for charcoal rot in soybeans 2Climate change provides good growing conditions for charcoal rot in soybeans 3New study finds that Adélie penguin population is on the rise 2New study finds that Adélie penguin population is on the rise 3
... CLEVELAND, Nov. 21, 2011 Already partnering with 43 ... world,s Top 100 Innovators, NineSigma today announced a record ... innovation is critical to their long-term growth. ... that never hesitate in their quest to innovate," said ...
... to measure their abundance has never been simple. A new ... and eight other scientists shows that expanding ocean dead zones ... wrinkle to that science. In the December 4 paper ... these scientists sound an alarm that expanding ocean dead zones ...
... Virginie Stevens ( CNRS ), Jean Clobert (CNRS), Michel ... show that interactions between dispersal and life-histories are complex, ... open access paper in the journal Ecology ... role in gene flow among populations, its evolutionary dynamics ...
Cached Biology News:Surging Demand for Innovation Services Leads to Record Expansion for NineSigma 2Surging Demand for Innovation Services Leads to Record Expansion for NineSigma 3Expanding dead zones shrinking tropical blue marlin habitat 2Expanding dead zones shrinking tropical blue marlin habitat 3Butterflies: 'Twice-punished' by habitat fragmentation and climate change 2
(Date:1/15/2014)... , "The interface is the device," Nobel laureate ... properties to be found at the junctures where ... world of nanotechnology, the interfaces between layers of ... in such high-tech favorites as spintronics, high-temperature superconductors, ...
(Date:1/15/2014)... 15, 2014 Cynvenio, a cancer diagnostics ... the genomic analysis of tumor cells in the bloodstream, ... web-based cancer decision support application powered by CollabRx, Inc. ... ClearID™ genomic test, Therapy Finder will provide breast cancer ...
(Date:1/15/2014)... 2014 More than 5 million Americans ... in 3 seniors will die with Alzheimer’s or another ... figures have shocked many Americans into looking for ways ... these tragic age-related cognitive disorders. Jonathan Weisman, president of ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 Freeslate, ... solutions, today announced that Lupin Limited, one of India’s ... CM Protégé PharmD System for high throughput ... India, is focused on a wide range of quality, ...
Breaking Biology Technology:A deeper look at interfaces 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3
... Wis. - NameProtect , a Madison-based supplier ... Wednesday it has entered a partnership with Corillian ... state of Oregon. , ,The companies will jointly market ... streamlining and improving both companies' anti-fraud solutions. The pairing ...
... is taking the business world by storm, or so it ... outsourcing topics featured in business and IT publications and websites. ... two recently released studies on outsourcing published by leading consulting ... accentuate the negative aspects of this management practice. , ,Both ...
... Madison, Wis. - Alfalight, Inc. , a ... and telecommunications markets, has been awarded $1.4 million in ... Diode Sources program, sponsored by the Defense Advanced ... the project is to increase a laser's power conversion ...
Cached Biology Technology:Is outsourcing reaching its limits or simply pausing for breath? 2Is outsourcing reaching its limits or simply pausing for breath? 3Is outsourcing reaching its limits or simply pausing for breath? 4Alfalight garners $1.4 million defense funding for diode program 2