Navigation Links
Protease inhibitors reach beyond HIV

The immunodeficiency that arises in HIV may be due to excessive programmed cell death of immune CD4 T cells. HIV protease inhibitors (PI) can block programmed cell death in virus-infected T cells in vitro, but have also been shown to induce programmed cell death at higher concentrations. The mechanisms for these paradoxical data are unclear, as is whether PI therapy would aid CD4 T cell reconstitution in HIV patients in vivo.

In a study appearing online on June 2 in advance of the print publication of the July 1 print issue of the Journal of Clinical Investigation, Andrew Badley and colleagues from Mayo Clinic examine whether PIs can inhibit programmed cell death in vivo and the mechanisms involved. The authors show that HIV PIs block programmed cell death induced by three relevant, virus-independent mouse models ?mice with experimental hepatitis, Staphylococcal-induced shock, and experimental stroke.

In each model, HIV PIs block programmed cell death and improve histology, survival, and function. The PIs prevent programmed cell death by maintaining mitochondrial integrity. These data show that PIs block programmed cell death in vivo and that related compounds may be useful for non-HIV disorders also characterized by excessive programmed cell death.


'"/>

Source:JCI


Page: 1

Related biology news :

1. HIV Patients May Be at Risk of Heart Problems When Taking Protease Inhibitor Drugs
2. Anthrax inhibitors identified by Burnham team
3. Enzyme inhibitors block replication of SARS virus
4. Sweet water taste paradoxically predicts sweet taste inhibitors
5. COX-2 inhibitors significantly reduce risk of cancer
6. Public collections of DNA and RNA sequence reach 100 gigabases
7. Natural vitamin E tocotrienol reaches blood at protective levels
8. NC State researchers redesign life for Mars and beyond
9. New classification of eukaryotes has implications for AIDS treatment, agriculture and beyond
10. Avian influenza virus in mammals spreads beyond the site of infection to other organ systems
11. Therapeutic prospects beyond Vioxx
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/15/2016)... 2016  A new partnership announced today will ... decisions in a fraction of the time it ... high-value life insurance policies to consumers without requiring ... Force Diagnostics, rapid testing (A1C, Cotinine and HIV) ... pressure, weight, pulse, BMI, and activity data) available ...
(Date:3/31/2016)... , March 31, 2016   ... ("LegacyXChange" or the "Company") LegacyXChange is excited ... of its soon to be launched online site for ... https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also provide potential shareholders a ... DNA technology to an industry that is notorious for ...
(Date:3/22/2016)... March 22, 2016 ... Sensors Market for Consumer Industry by Type (Image, ... Application (Communication & IT, Entertainment, Home Appliances, ... Forecast to 2022", published by MarketsandMarkets, the ... to reach USD 26.76 Billion by 2022, ...
Breaking Biology News(10 mins):
(Date:5/26/2016)... ... 2016 , ... FireflySci has been manufacturing quartz and glass ... the globe. Their cute firefly logo has been spreading to more and more ... calibration standards that never require recalibration. These revolutionary standards have changed many ...
(Date:5/25/2016)... ... May 25, 2016 , ... The American Medical Informatics ... of the National Coordinator for Health IT (ONC) outlining a measurement approach to ... were available when and where it was needed. The organization of health informatics ...
(Date:5/24/2016)... Mass. (PRWEB) , ... May 24, 2016 , ... ... heart attacks, diabetes, and traumatic injuries, will be accelerated by research at Worcester ... cells into engines of wound healing and tissue regeneration. , The novel method, ...
(Date:5/23/2016)... Ohio (PRWEB) , ... May 23, 2016 , ... ... Trends That Will Drive Precision Farming in 2017 and Beyond. The paper outlines ... practitioners in the precision ag industry. , “We’ve witnessed a lot of highs ...
Breaking Biology Technology: