Navigation Links
Prostate cancer uses Wnt signaling proteins to promote growth of bone tumors

Prostate cancer is a cruel disease. Left untreated, prostate cancer cells often metastasize, or spread, to bone where they form fracture-prone tumors that are extremely painful.

More than 80 percent of men who die from prostate cancer die with metastatic disease in their bones. But scientists know very little about how migrating prostate cancer cells set up housekeeping in bone tissue and produce the dense bony lesions characteristic of prostate cancer.

Now, new research by scientists at the University of Michigan's Comprehensive Cancer Center suggests that prostate cancer manipulates an important group of signaling proteins called Wnts (pronounced "wints") to establish itself in bone. By changing the amount and activity of Wnt proteins, prostate cancer cells upset the normal balance between formation and destruction of bony tissue.

"There is strong evidence that Wnt proteins play a central role in regulating normal skeletal development in an embryo," says Christopher L. Hall, Ph.D., a senior research fellow in urology at U-M. "But this is the first time Wnts have been shown to be involved in abnormal bone production in adult animals with prostate cancer."

Hall is first author of a paper to be published in the Sept. 1 issue of Cancer Research, which presents results from U-M studies of Wnt proteins in human prostate cancer cell lines and in laboratory mice injected with prostate cancer cells.

"Normal bone growth and remodeling depends on a controlled balance between production of new bone and resorption of existing bone," says Evan T. Keller, D.V.M., Ph.D., a professor of urology and pathology in the U-M Medical School, who directed the U-M study. "When a tumor forms in bone, it upsets this balance."

Several types of cancer metastasize to bone, according to Keller, but most of them tip the balance toward destruction ?producing what scientists call osteolytic lesions, or holes in the bone. Prostate cancer is unique in
'"/>

Source:University of Michigan Health System


Page: 1 2 3

Related biology news :

1. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
2. Estrogen-like Component of Plastic Stimulates Growth of Certain Prostate Cancer Cells
3. Penn Surgeons Use Completely Robotic Surgery to Successfully Treat Prostate Cancer
4. Viral DNA sequence a possible trigger for breast cancer
5. Enzyme, lost in most mammals, is shown to protect against UV-induced skin cancer
6. Its not all genetic: Common epigenetic problem doubles cancer risk in mice
7. Columbia research lifts major hurdle to gene therapy for cancer
8. Combination therapy boosts effectiveness of telomere-directed cancer cell death
9. Mitochondrial DNA mutations play significant role in prostate cancer
10. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
11. BRCA1 causes ovarian cancer through indirect, biochemical route
Post Your Comments:
(Date:7/11/2014)... Research awarded Michael F. Holick, PhD, MD, of Boston ... V. Avioli Award. Holick, a professor of medicine, physiology ... the understanding of vitamin D and its role in ... of the American Society for Bone and Mineral Research ... research. It is named for ASBMR,s first president and ...
(Date:7/11/2014)... researchers from The Chinese University of Hong Kong, BGI ... soybean linked to salt tolerance, with implication for improving ... study published online in Nature Communications provides ... crop improvement. , Soybean is an important crop for ... soybeans have less genetic diversities than their wild counterparts. ...
(Date:7/11/2014)... 11, 2014 Researchers have pioneered a revolutionary ... new technology, called Virtual Finger, allows scientists to ... neurons and synapses using the flat surface of ... 3D imaging studies orders of magnitude more efficient, ... level across many areas of experimental biology. The ...
Breaking Biology News(10 mins):BUSM's Michael F. Holick receives American Society for Bone and Mineral Research award 2BGI reports a novel gene for salt tolerance found in wild soybean 2Virtual finger enables scientists to navigate and analyze complex 3D images 2
... from the University California, San Diego (UCSD) Branch of ... Systems have developed an efficient method to identify thousands ... a study published today in Nature. , Genes are ... Thus the 'promoter' - a DNA sequence that controls ...
... States have found evidence of lichen-like symbiosis in 600-million-year-old ... lichen was 400 million years old, discovered in Scotland. ... of fungi and raises new questions about lichen evolution. ... of Geology and Palaeontology; Shuhai Xiao, assistant professor of ...
... Asian tsunami tragedy should be allowed to recover naturally ... some of the world's leading scientists. , The scientists, ... upon Tyne, and who set out their views in ... historical records of major coral reef devastation by cyclones ...
Cached Biology News:Whole genome promoter mapping - Human Genome Project v2.0? 2Evidence of 600-million-year old fungi-algae symbiosis discovered in marine fossils 2Evidence of 600-million-year old fungi-algae symbiosis discovered in marine fossils 3Tsunami-damaged coral reefs should be left to recover naturally, say scientists 2
(Date:7/10/2014)... (PRWEB) July 10, 2014 Unraveling life’s ... together. The Archer Family purchased a DNA ... DNA, but ended up with a lifetime of memories, ... within the family members’ DNA genuinely brought the family ... to search deeper into genetic history and prior to ...
(Date:7/10/2014)... OMICS Group’s 5th International conference and exhibition ... at Double Tree by Hilton Beijing, China is all ... & Bioanalytical research methods only to facilitate improved living ... Dr. Srinubabu Gedela, MD of OMICS Group Inc has ... one in bringing a unique and international mix of ...
(Date:7/10/2014)... Senior supply chain management executives from over 50 ... of “Reducing Cost, Lead Time, & Defects in the ... the partnership of the Bio Supply Management Alliance ( ... SCMI) of the University of San Diego in ... Institute of Peace and Justice in San Diego, Devendra ...
(Date:7/10/2014)... , July 10, 2014 On ... Dmitry Medvedev , presented Russia,s ... BIOCAD . The Company is developing a unique project ... project BIOCAD develops a number of innovative drugs based ... diseases. The ceremony took place at the International Exhibition ...
Breaking Biology Technology:Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2
... Fla., Feb. 12 CORD:USE Cord Blood Bank,is proud ... Jimmie Johnson has joined its team. "We,re honored to ... states Dr. Edward,Guindi, President and CEO of CORD:USE. Jimmie ... "Help Win the Race for Life(TM)",campaign., "I,m excited ...
... Powerful Multi-Modal Fusion Platform Includes Innovative Biometric ... ... Virginia, February 12 WCC Smart Search & Match,a leading ... with Retica Systems, a leader in providing,innovative eye biometric technology ...
... Feb. 12 /PRNewswire/ - Halogen Software Inc., a ... software,today announced that 2007 marked another record year ... quarter of 2007, included record,revenue with the company ... an offering that provides enterprise-level functionality to,organizations of ...
Cached Biology Technology:Two-time Defending NASCAR Sprint Cup Series Champion Jimmie Johnson Joins the Team at CORD:USE Cord Blood Bank to Help Win the Race for Life 2WCC Smart Search & Match and Retica Announce Global Collaboration 2Halogen Announces Record Year - Company Solidifies Leadership Position, Secures Strategic Wins Over Competition 2Halogen Announces Record Year - Company Solidifies Leadership Position, Secures Strategic Wins Over Competition 3
... MagicMark XP Western Protein Standards are ... protein molecular weight estimation directly on ... an IgG binding site, allowing direct ... used to detect your target protein ...
... TOPO Cloning is ... available for cloning PCR ... and Zero Blunt TOPO ... and activated with topoisomerase ...
... Conjugated peptides or recombinant proteins ... to produce antibodies in 2 rabbits. pre-immune ... ELISA test until the titer reaches 1:4,000 ... Protein G purification Antibodies are eluted ...
... Immunogen: Recombinant human IDO ... for the ~44 kDa human ... (positive control: IFN-Gamma-stimmulated Human peripheral ... homology reactivity with mouse and ...
Biology Products: