Navigation Links
Promising new West Nile therapy cures disease in mice

West Nile virus alarmed Americans when it made its first U.S. appearance in New York City in 1999. It has since spread from coast to coast, sickened more than 16,000 Americans and killed more than 600. As the virus spread, medical investigators hastened research to develop an effective vaccine or therapy. None currently exist, but a newly published paper by researchers at Washington University in St. Louis points to a promising treatment. This research, published today online by Nature Medicine, was funded in part by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

The research team developed an infection-fighting antibody that mimics one produced by people whose immune systems successfully fend off the West Nile virus. The researchers tested their antibody in mice and say its success warrants further development and testing in people with West Nile disease.

"West Nile virus has emerged in the United States as a regular seasonal threat, particularly for people over 50. We currently do not have a proven therapy for people with serious West Nile disease, so we will continue to aggressively pursue all promising leads for an effective treatment," says Anthony S. Fauci, M.D., director of NIAID.

Scientists do not know why some people infected with West Nile virus have no symptoms or a mild flu-like illness, while in others the virus invades the central nervous system and causes paralysis or coma. "We could give this antibody to mice as long as five days after infection, when West Nile virus had entered the brain, and it could still cure them," says Washington University senior investigator Michael Diamond, M.D., Ph.D., who headed the research team, which is supported in part by the NIAID-funded Midwest Regional Center of Excellence for Biodefense and Emerging Infectious Diseases. "It also completely protected the mice against death."

The researchers decided to develop the potential treatment--known as a monoclonal antibody--after finding that antibodies taken from the blood of people who recovered from West Nile fever could cure mice infected with West Nile virus. But antibodies derived from human blood have potential disadvantages: they vary in their ability to fight the disease, and although all precautions are taken to purify the antibodies, the blood might harbor other potentially dangerous infectious agents.

The Washington University scientists made 46 monoclonal antibodies against West Nile virus and then eliminated the less effective ones through a tedious molecular-level screening process. They then turned to Rockville, MD-based MacroGenics Inc., to create a human-like version of the most effective antibody. MacroGenics stitched the part of the antibody that cripples the West Nile virus into the scaffold of a human antibody. The monoclonal antibody was several hundred times more potent in cell culture tests than antibodies obtained from people who had recovered from West Nile virus infection.


'"/>

Source:NIH


Related biology news :

1. Another Look Finds Promising Proteomics Test is Not Biologically Plausible
2. Promising therapies for haemophilia & heart disease
3. Promising cell protein may play role in infection and dry eye
4. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
5. Columbia research lifts major hurdle to gene therapy for cancer
6. Combination therapy boosts effectiveness of telomere-directed cancer cell death
7. Gene therapy converts dead bone graft to new, living tissue
8. Study identifies predictors of HIV drug resistance in patients beginning triple therapy
9. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
10. Muscle-targeted gene therapy reverses rare muscular dystrophy in mice
11. New therapy for HIV/AIDS eliminates needles and excessive toxicity
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/7/2017)... , March 7, 2017   HireVue , the ... global companies identify the best talent, faster, today announced ... Sales Officer (CSO) and Diana Kucer as ... out a seasoned executive team poised to drive continued growth ... on a year of record bookings in 2017. ...
(Date:3/2/2017)... 2, 2017 Australian stem cell and regenerative ... has signed an agreement with the Monash Lung Biology ... Discovery Institute and Department of Pharmacology at Monash University, ... preclinical study to support the use of Cymerus™ mesenchymal ... Asthma is a chronic, long term lung ...
(Date:2/27/2017)... , Feb. 27, 2017   Strategic Cyber Ventures ... it has led a $3.5 million investment in  Polarity ... Strategic Cyber Ventures is DC based and is led ... Hank Thomas . Ron Gula , also a ... also participated in this series A round of funding. ...
Breaking Biology News(10 mins):
(Date:3/22/2017)... , March 22, 2017   iSpecimen ®, ... announced that Doctors Pathology Service (DPS), a ... of the United States , has ... Delaware Health Information Network (DHIN) to make human ... The novel program, announced in 2015 as ...
(Date:3/22/2017)... March 22, 2017   VWR ... of product and service solutions to laboratory ... has acquired EPL Archives, Inc., an international ... the entire regulated product research, development and ... storage and ancillary services. EPL Archives is ...
(Date:3/22/2017)... ... March 21, 2017 , ... ... more than tripling its goal and raising over $30,000 in the first 40 ... grows nutritious veggies & herbs fast, easy, and affordably, anywhere. , “Simply add ...
(Date:3/22/2017)... Iowa (PRWEB) , ... March 22, 2017 , ... March ... is time for another green revolution, one that utilizes technological innovation in smart, sustainable ... tangible aspects of life such as aesthetics and environmental stability. This paper is the ...
Breaking Biology Technology: