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Promiscuous Catalytic Activity Possessed by Novel Enzyme Structure

oduct in mind, they could feed interesting compounds to the enzyme and see what comes out. But researchers could also turn Orf2 into a more customized tool by using the techniques of genetic engineering to narrow its activity and tell it exactly which reactions to carry out.

“The big advantage that we have with our system is that it’s a small, soluble, easy-to-work-with bacterial protein that seems to be able to do reactions that you can find somewhere else in nature, but where people have not been able yet to isolate the proteins,?said Stéphane Richard. “So it’s kind of a short-cut ?it’s a way to bypass what is done already in nature, but for which we don’t have the tools yet that nature has.?/p>

The Salk Institute for Biological Studies in La Jolla, California, is an independent nonprofit organization dedicated to fundamental discoveries in the life sciences, the improvement of human health and the training of future generations of researchers. Jonas Salk, M.D., whose polio vaccine all but eradicated the crippling disease poliomyelitis in 1955, founded the Institute in 1960 on land donated by the City of San Diego and with the financial support of the March of Dimes.


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