Navigation Links
Promiscuous Catalytic Activity Possessed by Novel Enzyme Structure

Nature is a seemingly endless storehouse of interesting ?and potentially life-saving ?biological molecules. But tracking down and harvesting those chemicals in their natural form can be time-consuming, expensive and unreliable.

Now Salk scientists have discovered a new way of bringing “bio-prospecting?out of the rainforest and into the lab. Their findings are published in the June 16th edition of the journal Nature.

Stéphane Richard, Joseph Noel and Tomohisa Kuzuyama isolated and examined a totally new enzyme that can mix and match biological chemicals to create a wide range of different molecules that could be used as the basis for new drugs. The enzyme, named Orf2, takes chemical building blocks known as small aromatic molecules and changes them by adding a fat-like molecule called a prenyl group. That modification can have a huge impact on where the aromatic molecule goes within the cell, and what sort of effects it has when it reaches its target.

“When you make that so-called hybrid molecule, all the chemistry associated with the original compound changes,?said Noel. He explained that the addition of a prenyl group, also known as prenylation, produces a relatively large change in the chemical’s biological properties. “The molecule becomes a little bit more greasy, and so the kinds of targets that it might interact with change completely.?/p>

“We actually have in our hands now the ability to do things that a chemist might not be able to do, or if a chemist was able to do it, it could be expensive and time-consuming,?said Noel. “I think it’s a completely novel way to approach the whole area of bio-prospecting and new natural medicines.?/p>

The group was interested in manipulating the properties of small aromatic molecules because these bacteria- and plant-derived compounds are involved in a wide variety of important biological processes. Some are potent cancer-fighting anti-oxidants, while others have antibiotic or anti-fungal proper
'"/>

Source:Salk


Page: 1 2 3

Related biology news :

1. Noise And Delays Explain Why Some Genes Oscillate In Activity
2. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
3. Novel technology detects human DNA mutations
4. Novel antiviral technology inhibits RSV infection in mice
5. Novel Enzyme Shows Potential As An Anti-HIV Target
6. Novel Therapy Tested in Mice Could Chase Away Cat Allergies
7. Discovery Could Lead To Novel Approaches In HIV Treatment
8. Novel ultrafast laser detection of cancer cells also may improve understanding of stem cells
9. Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer
10. Novel gene-silencing nanoparticles shown to inhibit Ewings sarcoma
11. Novel live reporting system to track cells
Post Your Comments:
(Date:8/6/2015)... Germany , August 6, 2015 ... Instruments (SMI) shows the world,s first Eye ... on Epson,s Moverio BT-200 see-through head mounted display and ... solution, unprecedented quality and efficiency is brought to personalized ... For the first time, professionals and researchers can integrate ...
(Date:8/5/2015)... , Aug. 5, 2015 The biosensors ... growth in applications, penetration into newer sectors, and development ... The global biosensors space has seen the entry of ... market so far. (Photo - http://photos.prnewswire.com/prnh/20150805/255570 ... Sullivan, Analysis of the Global Biosensors Market ...
(Date:7/31/2015)... 2015 Den 10. internationale konference om Genomik ... 22. - 25. oktober i Shenzhen ... fødselsdag i år. Siden starten i 2006 er ICB ... ,omik,-feltet, og er en af de mest dynamiske, entusiastiske ... på nylige gennembrud og fremskridt inden for ,omik,-forskning, som ...
Breaking Biology News(10 mins):SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 2SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 3Innovative Biosensors Incite Use in Non-Traditional Applications 2Innovative Biosensors Incite Use in Non-Traditional Applications 3Innovative Biosensors Incite Use in Non-Traditional Applications 4Den 10. internationale konference om Genomics (ICG-10) åbner i oktober 2
... researchers from the National University of Singapore and the ... carotenoids to decreased hip fracture risk in elderly, lean ... In the study, the researchers examined the association between ... range of BMI in elderly Chinese men and women ...
... Favorable results have led to crizotinib gaining approval for ... cancer (NSCLC) in Japan, the United States, Canada, and ... identification of an effective therapy for ALK-positive NSCLC places ... find patients with this subtype of lung cancer. A ...
... 2012 A fast growing, flesh-eating fungus killed 5 ... according to two new studies based on genomic sequencing ... U.S. Centers for Disease Control and Prevention (CDC). ... the fungus Apophysomyces , according to the studies, ...
Cached Biology News:Study shows immunohistochemistry is reliable screening tool for ALK rearrangement 2Fungus responsible for 5 deaths in the wake of massive tornado 2Fungus responsible for 5 deaths in the wake of massive tornado 3
(Date:8/28/2015)... Brooklyn, NY (PRWEB) , ... August 28, 2015 , ... Since the initial launch of ... with their quirky humor and excellent customer service. Images such as the Fonz in ... website to add some flavor to the humdrum spectroscopy field. , FireflySci is ...
(Date:8/27/2015)... 27, 2015 /PRNewswire/ - Portage Biotech Inc. ("Portage") ... Biohaven Pharmaceutical Holding Company Limited (Biohaven), announced today ... study of BHV-0223, a glutamate modulating agent. Biohaven ... and recently obtained clearance from the U.S. Food ... testing. Portage holds 54% equity interest in Biohaven, ...
(Date:8/27/2015)... , Aug. 27, 2015 HUYA Bioscience ... meeting of the Japan Society of HTLV-1, held this ... Auditorium. The purpose of the Society is to promote ... the development of medical technology and research related to ... welfare. "HUYA is proud to support this ...
(Date:8/27/2015)... N.C. , Aug. 27, 2015 ... decision by FedEx, UPS and The US Postal ... biological specimens classified as ,select agents, by the ... history of handling these sensitive shipments. ... global transportation regulations, trained and certified personnel to ...
Breaking Biology Technology:Cuvette Manufacturer FireflySci Launches Back to School Deals with Complimentary Shipping On All Orders 2Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 2Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 3Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 4HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 2HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 3HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 4Marken Ensures Safe Transportation Of Select Agents And Toxins 2
... thought of as,a technology used only for computer ... technology are now being used for the,serious business ... Computing (BOINC), one of the leading distributed computing,platforms ... tap the massively parallel,processing power of NVIDIA GPUs ...
... Calif., Dec. 17 Senetek PLC,(OTC Bulletin Board: SNKTY), ... that target the science of healthy aging, today,announced that ... proposed at the Annual General Meeting of Shareholders held ... "We are pleased with the results of the ...
... 17 In a recent customer satisfaction,survey of over ... was voted by its customers as the "Top Of ... and pathologists who,subscribe to ADVANCE chose bioMerieux over other ... technical support," "reliable,instruments," and "quick response time." , ...
Cached Biology Technology:NVIDIA CUDA Technology Dramatically Advances the Pace of Scientific Research 2NVIDIA CUDA Technology Dramatically Advances the Pace of Scientific Research 3NVIDIA CUDA Technology Dramatically Advances the Pace of Scientific Research 4NVIDIA CUDA Technology Dramatically Advances the Pace of Scientific Research 5NVIDIA CUDA Technology Dramatically Advances the Pace of Scientific Research 6Senetek PLC Announces 2008 Annual General Meeting Voting Results 2Laboratory Customers Name bioMerieux 'Top Of Class' for Microbiology 2
...
...
... to CRF The antibody ... CRF sequence that it was ... are found in the paraventricular ... in colchicine treated 4% FA ...
...
Biology Products: