Navigation Links
Progress being made in exploring potential use of stem cells to treat heart disease

Scientists are making headway in exploring the potential future use of stem cells to treat heart disease, according to a review article in the current issue of Nature (June 29, 2006).

Authored by Gladstone Institute of Cardiovascular Disease Director Deepak Srivastava, MD, and Gladstone Institutes postdoctoral scholar Kathryn Ivey, PhD, the paper cites a better understanding of the following areas of research:

  • the developmental processes within the heart that can be reproduced using pluripotent embryonic stem cells (these are early stem cells that can grow into almost any cell type)
  • the cues that control multipotent cardiac stem cells (these stem cells, which have less developmental potential than embryonic stem cells, produce different types of cells that make up the heart)
  • the ability of circulating progenitor cells (early-stage cells that have not yet differentiated, or specialized) to produce factors that are sufficient to invoke cell survival or repair responses in damaged heart cells

"The use of stem cells to generate replacement cells for damaged heart muscle, valves, vessels and conduction cells holds great potential," says Srivastava, who is also a UCSF professor of pediatrics and the Wilma and Adeline Pirag Distinguished Professor in Pediatric Developmental Cardiology. "Although there are clearly many obstacles to overcome, it is significant that a roadmap of the derivation and use of stem cells for human heart disease is now conceivable."

In the Nature article, Srivastava and Ivey point to several challenges ahead:

  • Developing the ability not only to guide and expand stem cells into the cardiac lineage but also to repress alternative cell fates
  • Developing methods for safe delivery and proper integration of stem cells within patients' heart tissue to avoid such complications as arrhythmias (irregular heart beat)
  • Solving immunological issues surrounding rejection

    "Exciting new findings over the past 5 years indicate that stem cells could prove effective as protective or regenerative cardiac therapies," says Ivey, who was named in April one of seven current postdoctoral fellows participating in the Gladstone's new stem cell training program, funded by the California Institute for Regenerative Medicine. "The adult heart seems to have reservoirs of cardiac progenitor cells--adult stem cells that are destined to become cardiovascular cells--that may be able to replace a slow loss of cells over a lifetime. The coming years will undoubtedly bring new developments and technologies to unravel these processes, leading to clinical applications of stem cell-based therapies for heart disease."


    '"/>


Source:Gladstone Institutes


Related biology news :

1. Bevacizumab Combined With Chemotherapy Improves Progression-Free Survival for Patients With Advanced Breast Cancer
2. AIDS Public Awareness Campaign Expands Following Report Of Rapidly Progressive HIV
3. Progress on HIV/AIDS significant but insufficient
4. Progress made in HIV vaccine development
5. Progress toward artificial photosynthesis?
6. Emergence of cancer as major cause of childhood death in developing countries is not being adequately addressed
7. When it comes to cell entry, being average has its advantages
8. Sperm stem cells closer to being like embryonic stem cells
9. Nanotechnology being used to improve biocompatibility of human prosthetics and implants
10. Fat stem cells being studied as option for breast reconstruction
11. DNA layer reduces risk of reserve parts being rejected
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/23/2017)... Research and Markets has announced the addition of the ... Forecast to 2025" report to their offering. ... The Global Vehicle Anti-Theft System ... over the next decade to reach approximately $14.21 billion by 2025. ... forecasts for all the given segments on global as well as ...
(Date:3/22/2017)... , March 21, 2017 Optimove ... used by retailers such as 1-800-Flowers and AdoreMe, ... — Product Recommendations and Replenishment. Using Optimove,s machine learning ... personalized product and replenishment recommendations to their customers ... on predictions of customer intent drawn from a ...
(Date:3/20/2017)... At this year,s CeBIT Chancellor Dr. Angela Merkel visited the ... the DERMALOG stand together with the Japanese Prime Minster Shinzo Abe. ... largest German biometrics company the two government leaders could see the three ... as DERMALOG´s multi-biometrics system.   Continue Reading ... ...
Breaking Biology News(10 mins):
(Date:6/15/2017)... , ... June 15, 2017 , ... ... auxin herbicides give farmers new options for managing Palmer amaranth and other broadleaf ... (WSSA) say special precautions are necessary. Auxin herbicides are known to drift and ...
(Date:6/15/2017)... , ... June 15, 2017 , ... ... Gallery (EKG) follows an artist’s journey through creative experimentation and interdisciplinary collaboration. Feature ... runs through July 22nd. An opening reception will be held at EKG, located ...
(Date:6/15/2017)... ... June 15, 2017 , ... ... DuPont Biofuels, will be speaking at Bloomberg’s 2017 Sustainable Business Summit: Seattle ... leading environmental and sustainability officials on a panel titled “Developing a Corporate Renewables ...
(Date:6/14/2017)... ... June 14, 2017 , ... ... discuss the initiative steered by the executive search firm, “Building Value in Precision ... Board of Directors of Foundation Medicine, led an open discussion with expert panelists ...
Breaking Biology Technology: