Navigation Links
Progress being made in exploring potential use of stem cells to treat heart disease

Scientists are making headway in exploring the potential future use of stem cells to treat heart disease, according to a review article in the current issue of Nature (June 29, 2006).

Authored by Gladstone Institute of Cardiovascular Disease Director Deepak Srivastava, MD, and Gladstone Institutes postdoctoral scholar Kathryn Ivey, PhD, the paper cites a better understanding of the following areas of research:

  • the developmental processes within the heart that can be reproduced using pluripotent embryonic stem cells (these are early stem cells that can grow into almost any cell type)
  • the cues that control multipotent cardiac stem cells (these stem cells, which have less developmental potential than embryonic stem cells, produce different types of cells that make up the heart)
  • the ability of circulating progenitor cells (early-stage cells that have not yet differentiated, or specialized) to produce factors that are sufficient to invoke cell survival or repair responses in damaged heart cells

"The use of stem cells to generate replacement cells for damaged heart muscle, valves, vessels and conduction cells holds great potential," says Srivastava, who is also a UCSF professor of pediatrics and the Wilma and Adeline Pirag Distinguished Professor in Pediatric Developmental Cardiology. "Although there are clearly many obstacles to overcome, it is significant that a roadmap of the derivation and use of stem cells for human heart disease is now conceivable."

In the Nature article, Srivastava and Ivey point to several challenges ahead:

  • Developing the ability not only to guide and expand stem cells into the cardiac lineage but also to repress alternative cell fates
  • Developing methods for safe delivery and proper integration of stem cells within patients' heart tissue to avoid such complications as arrhythmias (irregular heart beat)
  • Solving immunological issues surrounding rejection

    "Exciting new findings over the past 5 years indicate that stem cells could prove effective as protective or regenerative cardiac therapies," says Ivey, who was named in April one of seven current postdoctoral fellows participating in the Gladstone's new stem cell training program, funded by the California Institute for Regenerative Medicine. "The adult heart seems to have reservoirs of cardiac progenitor cells--adult stem cells that are destined to become cardiovascular cells--that may be able to replace a slow loss of cells over a lifetime. The coming years will undoubtedly bring new developments and technologies to unravel these processes, leading to clinical applications of stem cell-based therapies for heart disease."


    '"/>


Source:Gladstone Institutes


Related biology news :

1. Bevacizumab Combined With Chemotherapy Improves Progression-Free Survival for Patients With Advanced Breast Cancer
2. AIDS Public Awareness Campaign Expands Following Report Of Rapidly Progressive HIV
3. Progress on HIV/AIDS significant but insufficient
4. Progress made in HIV vaccine development
5. Progress toward artificial photosynthesis?
6. Emergence of cancer as major cause of childhood death in developing countries is not being adequately addressed
7. When it comes to cell entry, being average has its advantages
8. Sperm stem cells closer to being like embryonic stem cells
9. Nanotechnology being used to improve biocompatibility of human prosthetics and implants
10. Fat stem cells being studied as option for breast reconstruction
11. DNA layer reduces risk of reserve parts being rejected
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/24/2017)... 2017 The Controller General of Immigration from Maldives ... Algeen have received the prestigious international IAIR Award for the most ... Reading ... Maldives ... Abdulla Algeen (small picture on the right) have received the IAIR award ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based and ... 2022", published by MarketsandMarkets, the market is expected to be worth USD 18.98 ... Continue Reading ... ...      ...
(Date:3/22/2017)...   Neurotechnology , a provider of high-precision ... the release of the SentiVeillance 6.0 ... recognition using up to 10 surveillance, security and ... new version uses deep neural-network-based facial detection and ... a Graphing Processing Unit (GPU) for enhanced speed. ...
Breaking Biology News(10 mins):
(Date:8/17/2017)... ... August 17, 2017 , ... ... market news outlet had provided a research update on Aytu Bioscience and cited ... product. , According to Soulstring, prescription rates for Natesto® have more than doubled ...
(Date:8/16/2017)... ... August 16, 2017 , ... ... Fluidnatek® Electrospinning and Electrospraying line of nanofiber and ... table-top equipment for the lab to fully automated pilot plants and equipment ...
(Date:8/16/2017)... (PRWEB) , ... August 16, 2017 , ... ... beneficial microbe delivery system, announced it has secured $2M in funding from an ... City Angels, Carmen Innovations, and SVG Thrive Fund. With this investment, 3Bar is ...
(Date:8/16/2017)... OXFORD, England , Aug. 16, 2017 /PRNewswire/ ... biotech executive search and leadership development, and Virdis Group, global ... created an exclusive alliance that enables clients to leverage the ... "For our clients here in the ... to a diverse population of leadership talent throughout the US, ...
Breaking Biology Technology: