Navigation Links
Program finds lost genes in nematode genome

becoming clear that machines can beat human annotators and analysts, on average," he said.

Because of the increasing speed of computers, the TWINSCAN analysis of C. Elegans is able to use more accurate models of intron length than previous analyses. This is important for finding exons, which house the coding machinery of proteins. While getting intron length is helpful for gene annotation, the process is 15 times slower than the typical, less accurate methods. Being able to define intron length has implications for the human genome, which is much larger than C. elegans and has an average intron length of about 4,000 base pairs, compared with an average intron length of a couple hundred base pairs in C. elegans.

Brent and colleagues from the Dana-Farber Cancer Institute and Harvard Medical School published their findings in the April, 2005 issue of Genome Research. Brent's graduate student, Chaochun Wei, is first author on the paper. The research was supported by grants from NIH, NSF, the National Cancer Institute, the National Human Genome Research Institute, and the National Institute of General Medical Sciences.
Michael Brent
Michael Brent

Brent has brought his bioinformatics skills to many genomes, including those of mammals, other nematode species and most recently the fungus Cryptococcus neoformans. Brent's approach to gene prediction stands traditional genome annotation on its head because it starts with a computer analysis of the genome sequence, using that as a hypothesis designing experiments to test the hypothesis. The traditional modus operandi is a data-driven approach that starts with sequencing a random sample of tens of thousands of cDNA clones. Whereas the traditional approach leads to sequencing some genes thousands of times and others not at all, Brent's approach is to sequence each predicted gene once.

"I've been building a case that we should start with predictions," he said. "Each gene sequence is mor
'"/>

Source:Washington University in St.Louis


Page: 1 2 3

Related biology news :

1. Applied Biosystems Introduces Advanced Gene Expression Service Provider Program
2. Programmable cells: Engineer turns bacteria into living computers
3. Current human embryonic stem cell lines contaminated UCSD/Salk team finds
4. Study finds more than one-third of human genome regulated by RNA
5. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
6. Same mutation aided evolution in many fish species, Stanford study finds
7. NC State scientist finds soft tissue in T. rex bones
8. Genrate: a generative model that finds and scores new genes and exons in genomic microarray data
9. Genetically modified rice in China benefits farmers health, study finds
10. Survey finds silver contamination in North Pacific waters
11. Anti cancer virotherapy well tolerated in first human administration, research finds
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Program finds lost genes nematode genome

(Date:7/11/2014)... 2014, Shenzhen, China Researchers from Salk Institute for ... first time evaluated the safety and reliability of ... developed a new method, TALEN-HDAdV, which could significantly ... cell (hiPSC). This study published online in ... foundation for stem cell-based gene therapy. , The ...
(Date:7/11/2014)... 2014 The increased risk of kidney injury related ... fluids reflects the mass of HES molecules, according to ... journal of the International Anesthesia Research Society (IARS). , ... effect of HES on cultured human renal proximal tubule ... Wunder and colleagues of University Hospital Wrzburg, Austria. ...
(Date:7/11/2014)... 11, 2014 Research and Markets ... Technology Market - Industry Analysis Size Share Growth Trends ... http://photos.prnewswire.com/prnh/20130307/600769 ... created a need for high level security in both ... authentication such as username and passwords, tokens etc. are ...
Breaking Biology News(10 mins):A new genome editing method brings the possibility of gene therapies closer to reality 2In lab studies, hydroxyethyl starch has direct harmful effects on kidney cells 2International Biometrics Technology Market - Industry Analysis Size Share Growth Trends and Forecast to 2019 2
... , PHILADELPHIA - A recently identified immune cell that ... role in regulating the immune system in both health ... of Medicine have discovered how a stimulatory molecule and ... cell make T helper 17 cells multi-taskers of sorts. ...
... USA - Scientists have discovered in China the first ... land animals the sauropod dinosaurs. The new species, ... flood plains around Lufeng in the Yunnan Province of ... helps explain how the iconic four-footed, long-necked sauropod dinosaurs ...
... branches of trees hemming the shorelines during the deadly ... in Indonesia, India, Thailand and Sri Lanka. In the ... from the U.S. Geological Survey (USGS) decided to explore ... up valuable forest ecosystems called mangroves -- safeguard lives, ...
Cached Biology News:Penn study shows 2-sided immune cell could be harnessed to shrink tumors 2Found: First complete remains of early sauropod dinosaur 2Root of the matter: A new map shows life-saving forests' scarcity defies past estimates 2Root of the matter: A new map shows life-saving forests' scarcity defies past estimates 3Root of the matter: A new map shows life-saving forests' scarcity defies past estimates 4Root of the matter: A new map shows life-saving forests' scarcity defies past estimates 5
(Date:7/10/2014)... lithium-ion batteries that power our laptops and electric vehicles ... single charge with the help of a sponge-like silicon ... replace the graphite traditionally used in one of the ... the energy storage capacity of graphite. A paper describing ... published today in Nature Communications . , "Silicon ...
(Date:7/10/2014)... for crude 3-D glasses, polarized glasses, and shutter ... devices, used to trick the brain into perceiving ... obsolete with the introduction of new holography technology ... doctoral students Yuval Yifat, Michal Eitan, and Zeev ... nanoantennas that could be used for security as ...
(Date:7/10/2014)... and NPL collaborate to bring together their track record ... academic strengths., Working with BIS and NPL the successful ... the UK. The establishment of a Graduate Institute, which ... provide a pipeline of skilled researchers. Working with the ... be grown through the creation of a series of ...
(Date:1/15/2014)... , "The interface is the device," Nobel laureate ... properties to be found at the junctures where ... world of nanotechnology, the interfaces between layers of ... in such high-tech favorites as spintronics, high-temperature superconductors, ...
Breaking Biology Technology:Silicon sponge improves lithium-ion battery performance 2Silicon sponge improves lithium-ion battery performance 3Projecting a 3-dimensional future 2Projecting a 3-dimensional future 3Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 2Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 3A deeper look at interfaces 2
... Powerful effects seen in all subjects including those ... of myocardial infarct patients, TSX Exchange Symbol: ... or the "Company") (TSX:RVX) announced today that results from the ... by successfully concluding the drug, RVX-208, is safe and tolerable. ...
... fills the world,s landfills into biofuel may be the ... tackling carbon emissions, claim scientists in Singapore and Switzerland. ... , reveals how replacing gasoline with biofuel from processed ... Biofuels produced from crops have proven controversial because they ...
... ARBOR, Mich.---University of Michigan physicists have created the ... step toward the goal of producing "designer dots" ... Quantum dots---often called artificial atoms or nanoparticles---are tiny ... photovoltaic cells, light-emitting devices and other technologies. Each ...
Cached Biology Technology:Resverlogix RVX-208 Second Clinical Trial Demonstrates Success on Key Reverse Cholesterol Transport Markers 2Resverlogix RVX-208 Second Clinical Trial Demonstrates Success on Key Reverse Cholesterol Transport Markers 3Resverlogix RVX-208 Second Clinical Trial Demonstrates Success on Key Reverse Cholesterol Transport Markers 4Resverlogix RVX-208 Second Clinical Trial Demonstrates Success on Key Reverse Cholesterol Transport Markers 5U-M physicists create first atomic-scale map of quantum dots 2
RayBio Human Atherosclerosis Antibody Array 1.1 (4) with Accessory, detects 40 inflammatory factors (for lysate) Class: Antibody Array Products Product Group: Antibody Array...
Ultra Pure Grade. Used in conjunction with IPTG to identify bacterial colonies that contain recombinant plasmids by blue/white selection. X-Gal forms an intense blue precipitate in the presence of be...
Request Info...
4-Hydroxy-3-nitrophenylacetyl hapten is conjugated to SSA (Sheep serum albumin) lysine through amide bonds. This product is homologous to NP-BSA....
Biology Products: