Navigation Links
Products containing specific probes for detecting alternative splice forms protected

ExonHit Therapeutics, today announced the grant of a major patent, US # 6,881,571, by the United States Patent and Trademark Office on microarray products allowing the specific detection of mRNAs produced by alternative splicing, covering microarrays optimised for the discovery of alternative RNA splicing events. The patent protects the probe configuration of a unique set of five oligonucleotides for the detection of each splice variant. There are many applications for this patent, including drug discovery, diagnostics, and compound screenings for efficacy or toxicity as well as screening patients for potential efficacy of therapeutics.

Alternative RNA Splicing is a critical step in the expression of most genes, which can result in the expression of several mRNAs encoding proteins with different functions from a single gene. Splicing events are implicated in numerous pathologies and can be altered by various stress events such as virus, toxic agents, and drug exposure.

The genome-wide patented probe configuration described in the patent is the basis for the microarrays in ExonHit's SpliceArray product line launched earlier this year. The genome profiling market is rapidly growing, and SpliceArrays are the only commercially available microarrays designed to detect alternative splicing. Current SpliceArray products include GPCR, Ion Channel, and Nuclear Receptor family SpliceArrays, as well as custom design services. An Apoptosis and Cytokine gene family array will be launched in the coming months. SpliceArrays are manufactured for ExonHit by Agilent Technologies.

The granting of this patent solidifies ExonHit's leadership in the field of expression profiling and positions the company as the only partner for the conception or use of gene profiling microarrays that include alternative RNA splicing. "The granting of these claims build on the company's core assets further expanding our IP position in the field of gene expression and profiling," sta ted Bruno Tocque, President and CEO, ExonHit Therapeutics. "This is a significant event for ExonHit as we have been quite successful in leveraging strategic assets in multiple arenas, including the therapeutic, diagnostic and research tool markets ?areas in which these claims will further increase our market share."


'"/>

Source:ExonHit


Related biology news :

1. Metal-containing compounds show promise as HIV weapon
2. Preventing a pandemic: Study suggests strategies for containing a flu outbreak
3. Rapid response was crucial to containing the 1918 flu pandemic
4. Scientists generate patient-specific stem cells, Science study says
5. Identification of specific genes predicts which patients will respond to Hepatitis C treatment
6. Eating, body weight regulated by specific neurons
7. Tool developed to silence genes in specific tissues using RNAi
8. Gene-specific Ebola therapies protect non-human primates from lethal disease
9. Unique dual target specificity of kinase inhibitor key for success against cancer
10. Serotonin, acting in a specific brain region, promotes sleep in fruit flies
11. A new male-specific gene in algae unveils an origin of male and female
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2017)... , April 13, 2017 According to a new ... Authentication, Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, ... IAM Market is expected to grow from USD 14.30 Billion in 2017 ... (CAGR) of 17.3%. ... MarketsandMarkets Logo ...
(Date:4/11/2017)... N.Y. , April 11, 2017 ... fingerprints, but researchers at the New York University ... College of Engineering have found that partial similarities ... security systems used in mobile phones and other ... thought. The vulnerability lies in the ...
(Date:4/5/2017)... SEATTLE , April 5, 2017  The Allen ... the Allen Cell Explorer: a one-of-a-kind portal and dynamic ... large-scale 3D imaging data, the first application of deep ... edited human stem cell lines and a growing suite ... the platform for these and future publicly available resources ...
Breaking Biology News(10 mins):
(Date:4/27/2017)... Monterey, California (PRWEB) , ... April 27, 2017 ... ... a new infographic explaining why mass flow controllers based on capillary thermal mass ... for industrial gas mass flow control applications. Over 80% of all industrial ...
(Date:4/27/2017)... , April 27, 2017  Kinexum, a distinguished resource ... today announces the appointment of Thomas C. Seoh ... ("Zan") Fleming, M.D., Kinexum founder, who becomes Executive Chairman ... to Kinexum clients. Thomas Seoh ... the Kinexum mission and lead the firm,s remarkable team ...
(Date:4/26/2017)... ... April 26, 2017 , ... Baltimore bio tech ... mail security screening solution at the National Postal Forum 2017 in Baltimore, Maryland, ... fast, highly accurate, easy to use and low cost threat detection solution for ...
(Date:4/25/2017)... (PRWEB) , ... April 25, 2017 , ... ... (AI), leading supplier of Common Lisp (CL) development tools, and market leader for ... which includes key performance enhancements now available within the most effective system for ...
Breaking Biology Technology: