Navigation Links
Probing the promise and perils of nanoparticles

recently, Leroueil studied other types of charged nanoparticles called polycationic polymers---already being used to deliver drugs and genes---to see if they behaved like dendrimers. "It turns out that they cause the same permeability and, in general, they cause membrane destruction as well," said Banaszak Holl. Neutral polymers, however, did not damage membranes.

Both Leroueil's work and the earlier research used model membranes to probe the effects of nanoparticles. Now, the research group is exploring their interactions with living cells.

"Just because we see hole formation in the model system doesn't mean that it really happens in the cell," said Banaszak Holl. But early results of experiments with living cells suggest that the same types of nanoparticles that punch holes in model membranes also damage membranes in living cells and make the membranes more permeable. Hong is now trying to learn more about the biological mechanisms involved. The usual explanation for how polycationic polymers and similar nanoparticles get into cells involves a process called polycation-mediated endocytosis. But Hong's experiments suggest that nanoscale hole formation may be at least as important in allowing materials to travel through membranes.

The work that Banaszak Holl, Hong and Leroueil will discuss is one of several major research programs under way in the U-M Center for Biologic Nanotechnology---a multi-disciplinary group includes researchers from the Medical School, the College of Engineering, and the College of Literature, Science, and the Arts, and focuses on biomedical applications of nanomaterials. Collaborators on this work include James R. Baker, Jr., the Ruth Dow Doan Professor of Biologic Nanotechnology; Bradford Orr, professor of physics and director of the Applied Physics Program; research associate Jennifer Peters and research investigators Anna Bielinska and Istvan Majoros.


'"/>

Source:University of Michigan


Page: 1 2

Related biology news :

1. Probing The Promise And Perils Of Nanoparticles
2. Priming embryonic stem cells to fulfill their promise
3. Polymers with copper show promise for implanted sensors
4. New drug shows promise as powerful anticancer agent
5. Test for early detection of prostate cancer shows promise
6. Confocal imaging promises early detection of skin cancer
7. Its electric: Cows show promise as powerplants
8. Unusual antibiotics show promise against deadly superbugs
9. Novel compounds show promise as safer, more potent insecticides
10. Compound from Chinese medicine shows promise in head and neck cancer
11. Discovery of T-cell traffic control boosts new drug promise
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Probing the promise and perils nanoparticles

(Date:5/22/2013)... biodiversity of pollinating insects and wild plants have slowed ... Researchers led by the University of Leeds and the ... of dramatic reductions in the diversity of species in ... 1980s. , But the picture brightened markedly after 1990, ... among bees, hoverflies and wild plants. , ...
(Date:5/21/2013)... considered in the management of natural resources, and ... help them recognize and respond to the relationships ... , Place-Based Conservation: Perspectives from the Social ... Northwest Research Station,s Linda Kruger, can help managers ... is published by Springer Verlag and is available ...
(Date:5/21/2013)... Northwestern University researchers have developed a new method ... temporary holes in the cell surface. The technique ... and related biological fields. , Bulk electroporation ... through reversible nanopores in the cell membrane that ... is an increasingly popular method of cell ...
Breaking Biology News(10 mins):Encouraging signs for bee biodiversity 2Encouraging signs for bee biodiversity 3Single-cell transfection tool enables added control for biological studies 2
... - (BRONX, NY) - The fact that they eat a lot ... mammals are protected from the majority of fungal pathogens, according to ... The research, published in the Journal of Infectious Diseases ... familiar 98.6o F or 37o C in people is too ...
... made a discovery that promises to deliver a new approach ... all mammals not just humans or another particular species. ... biological ,barcodes, of infectious microbes such as food poisoning bacteria, ... be made to prevent a particular disease in all mammals. ...
... Oct. 15 issue of the Journal of Clinical Sleep ... program may benefit obese patients with mild to moderate obstructive ... Results show improvement in typical OSA symptoms including ... mood after the completion of a 16-week diet and exercise ...
Cached Biology News:Do 3 meals a day keep fungi away? 2Bug barcode readers hold out promise of universal vaccines 2Improved diet and exercise alone unlikely to cure obstructive sleep apnea in obese patients 2
(Date:5/22/2013)... AudioNotch is the ... treatment. AudioNotch is pleased to announce a partnership ... in both British Columbia and Alberta, Destination Hearing ... services. AudioNotch's tinnitus treatment program is now available ... Destination Hearing clinic, patients have the detection of ...
(Date:5/22/2013)... Alton Housing Authority was hit by bed bugs. A report ... presence has already caused the company $35,000 for treatment. Wanting ... My Cleaning Products shared a way how to kill ... report that to clear the infestation , the company ... also attended a mandatory training on bed bugs, it added. ...
(Date:5/22/2013)... 2013 The ability to sequence ... information they encode. There are now a suite ... of ribosome protected fragments) that dramatically expand our ... speakers include Dr. Jonathan Weissman, an Investigator with ... Hughes Medical Institute, who will present recent applications ...
(Date:5/21/2013)... WEST PALM BEACH, Fla. , May 21, ... Inc. (NYSE: FCN ), the global ... and enhance their enterprise value (the "Company"), announced ... sciences focused personnel that were formerly included within ... Forensic and Litigation Consulting segment to form a ...
Breaking Biology Technology:AudioNotch Tinnitus Treatment Launches Partnership With Destination Hearing 2Bed Bugs Cost Alton Housing Authority $35,000; New Help, How to Kill Bed Bugs With Less Expense, Introduced by My Cleaning Products 2Monitoring Protein Synthesis One Codon at a Time Through Ribosome Profiling, a Webinar Hosted by Xtalks 2FTI Consulting Releases Realigned Segment Information Reflecting Newly Combined Health Solutions Practice 2
... DALLAS, February 1, 2012 The report ... -   Global Trends, Opportunities & Forecasts (2011   - ... and studies the major market drivers, restraints, and opportunities in ... Browse market data tables and in-depth TOC ...
... 2012 New Report Added in ... Global Markets The report provides ... DDS and future opportunities (2011-2021).  Persons with a financial ... to learn how advances in nanotechnology research and development ...
... in Dayton, Ohio, has experimentally confirmed a theory by ... of interesting properties about nanotube growth: That the chirality ... and that armchair nanotubes should grow the fastest. ... the mysteries inherent in what Yakobson calls the "DNA ...
Cached Biology Technology:MarketsandMarkets: Global Biomarkers Market worth $25.79 Billion by 2016 2MarketsandMarkets: Global Biomarkers Market worth $25.79 Billion by 2016 3ResearchMoz: Nanotech Enabled Drug Delivery Therapeutics Market Will be $136 Billion by the Year 2021: Nanotechnology in Drug Delivery: Global Markets 2ResearchMoz: Nanotech Enabled Drug Delivery Therapeutics Market Will be $136 Billion by the Year 2021: Nanotechnology in Drug Delivery: Global Markets 3ResearchMoz: Nanotech Enabled Drug Delivery Therapeutics Market Will be $136 Billion by the Year 2021: Nanotechnology in Drug Delivery: Global Markets 4Rice professor's nanotube theory confirmed 2Rice professor's nanotube theory confirmed 3