Navigation Links
Probing the promise and perils of nanoparticles

For all its promise, the prospect of using nanoparticles in biomedical applications and consumer products has raised concerns about possible harmful effects of the miniscule materials. Scientists at the University of Michigan are addressing those concerns by investigating how certain kinds of nanoparticles damage cell membranes---enough to cause cell death in some cases---and how the damage can be prevented.

"If you're inventing these sorts of materials, you need to be concerned about their impact," said Mark Banaszak Holl, a U-M professor of chemistry and of macromolecular science and engineering. "We're trying to do both: make important new materials and be excited about what can be done with them, but at the same time, understand what their potential downsides might be." Banaszak Holl and graduate students Pascale Leroueil and Seungpyo Hong will discuss their research at the 229th national meeting of the American Chemical Society in San Diego March 13-17.

In collaboration with other researchers at U-M's Center for Biologic Nanotechnology, Banaszak Holl's lab has been studying nanoparticles known as dendrimers, tiny spheres whose width is ten thousands times smaller than the thickness of a human hair. Dendrimers have shown promise for precisely delivering drugs to their targets inside the body, but high concentrations of these nanoparticles can be toxic. In earlier work, U-M researchers discovered that dendrimers punch nanoscale holes in cell membranes, making the membranes more permeable. At high enough concentrations, they can completely destroy the membranes, killing cells in the process. But the damage can be prevented by engineering dendrimers in particular ways, such as modifying their surfaces to make them neutral instead of charged, the scientists found. And, added Banaszak Holl, "not only does engineering make them less harmful, but it also makes them better at what we want them to do. You don't lose anything; it's all a gain."

More
'"/>

Source:University of Michigan


Page: 1 2

Related biology news :

1. Probing The Promise And Perils Of Nanoparticles
2. Priming embryonic stem cells to fulfill their promise
3. Polymers with copper show promise for implanted sensors
4. New drug shows promise as powerful anticancer agent
5. Test for early detection of prostate cancer shows promise
6. Confocal imaging promises early detection of skin cancer
7. Its electric: Cows show promise as powerplants
8. Unusual antibiotics show promise against deadly superbugs
9. Novel compounds show promise as safer, more potent insecticides
10. Compound from Chinese medicine shows promise in head and neck cancer
11. Discovery of T-cell traffic control boosts new drug promise
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Probing the promise and perils nanoparticles

(Date:5/21/2015)... , May 21, 2015 The Sync ... of music for health, today announced a collaborative partnership ... The partnership will center on collaboration on original research, ... first step in the collaboration, The Sync Project and ... "Music as Medicine" in the 2015-2016 academic year.  ...
(Date:5/20/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... LLC, a company engaged in biometric identification is an ... portion of the recently awarded TIES (Technical Information Engineering ... Army. 3D-ID LLC has a suite of ... and security agencies. Gino Pereira , ...
(Date:5/19/2015)... 19, 2015  Technology is rapidly advancing, outpacing enterprises, ... the cloud. Passwords and their management are soon to ... standards-based specifications such as those developed by the FIDO ... passwords presents for BYOD, COPE, IoT, and mobile payments, ... protocol. In response to the call ...
Breaking Biology News(10 mins):The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 2The Sync Project Announces Partnership with Berklee College of Music's Institute for Creative Entrepreneurship 3NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 2NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 3HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 2HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 3
... report released today by the University of Victoria ranks ... to the environment. It is the first study to ... unlabeled options in the marketplace. "How Green ... sort through competing sustainability claims and better identify those ...
... bane of picky eaters everywhere, broccoli,s taste is not just ... easily taste a bitter compound in the vegetable that others ... helped uncover the evolutionary history of one of the genes ... the gene, the researchers discovered something unexpected: something other than ...
... of additional radioactive leaks from Fukushima nuclear power plants, ... from the plants remains unclear. But a new study ... radioactivity discharged from the facility in the first four ... about the history of contaminant releases to the ocean., ...
Cached Biology News:New study puts eco-labels to the test 2Penn geneticists help show bitter taste perception is not just about flavors 2Penn geneticists help show bitter taste perception is not just about flavors 3Researchers assess radioactivity released to the ocean from the Fukushima nuclear facility 2Researchers assess radioactivity released to the ocean from the Fukushima nuclear facility 3
(Date:5/21/2015)... , May 21, 2015 ... inner feelings - and those of others. Being able ... senses. Analyze and read people to anticipate their thoughts ... your deepest emotions and feelings to create unique abstract ... of responsive games. Get inside a first-person-shooter as it ...
(Date:5/21/2015)... May 20, 2015 Research and Markets ... of the "2015 Global Survey on Flow ... The primary goal of this research ... instruments and reagents. Key information the survey seeks ... of flow cytometers, predominantly used applications for flow ...
(Date:5/20/2015)... , May 20, 2015 Research and Markets ... the "Top Technologies in HW_Technical Insights" report ... this report evaluated technology trends in the Health and ... are likely to have an impact in the year ... of the top 10 health and wellness technologies that ...
(Date:5/20/2015)... May 20, 2015  Health eCareers, the healthcare ... organizations with job seekers looking for the flexibility ... new mobile and online tool dedicated exclusively to ... SHIFT enables employers to quickly find ... nursing, per diem and other temporary positions, eliminating ...
Breaking Biology Technology:5 Days to Meet ARGUS - The World's First Contactless Emotions Scanner 2Global Survey on Flow Cytometry Adoption Trends 2015 2Top Technologies in the Health and Wellness Industry 2015 2Health eCareers Launches SHIFT Mobile and Online Tool to Match Healthcare Employers with Temporary Job Seekers 2Health eCareers Launches SHIFT Mobile and Online Tool to Match Healthcare Employers with Temporary Job Seekers 3
... 2011  MacroGenics, Inc., a privately held biotechnology company ... that it will receive a milestone payment from ... part of an agreement executed in October 2010 ... on MacroGenics, Dual-Affinity Re-Targeting (DART) platform.  The amount ...
... in everyday materials, polymers and the field of ... U.S. economy. Polymers possess unique properties and processing ... For these reasons, advances in polymer science ... 21st century challenges of energy, sustainability, clean water, ...
... /PRNewswire-Asia-FirstCall/ -- China Cord Blood Corporation (NYSE: CO ) ... blood banking operator in China, today announced the results of ... 19, 2011, in Hong Kong. At the Annual ... and Dr. Yungang (Ken) Lu to serve on the Board ...
Cached Biology Technology:MacroGenics Receives Milestone Payment as Part of Its Global DARTâ„¢ Alliance with Boehringer Ingelheim 2Research and education success earns more NSF funding 2Research and education success earns more NSF funding 3China Cord Blood Corporation Announces Results of 2011 Annual General Meeting 2
Mouse Anti-Amyloid beta [1-16], clone 6E10, Monoclonal Antibody...
The pCDF Expression System 1 plus Competent Cells contains 10 µg of pET-45b(+) DNA. pET-45b carries an N-terminal His•Tag ® coding sequence that is cleavable with enterokinase as well...
Nucleobindin 1 [NUCB1]...
Request Info...
Biology Products: