Navigation Links
Prion disease treatable if caught early

to neuronal function and survival in prion-infected mice we have shown here support targeting neuronal [prion protein] directly as a therapeutic approach," wrote Mallucci and colleagues.

"Our findings of early reversible neurophysiological and cognitive deficits occurring prior to neuronal loss open new avenues in the prion field," they wrote. "To date, prion infection in mice has conventionally been diagnosed when motor deficits reflect advanced neurodegeneration. Now the identification of earlier dysfunction helps direct the study of mechanisms of neurotoxicity and therapies to earlier stages of disease, when rescue is still possible.

"Eventually it may also enable preclinical testing of therapeutic strategies through cognitive endpoints. These data now lead to the hope that early intervention in human prion disease will not only halt clinical progression but allow reversal of early behavioral and cognitive abnormalities," wrote the scientists.
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Fibril Shape Is The Basis Of Prion Strains And Cross-species Prion Infection
2. Active Vaccine Prevents Mice From Developing Prion Disease
3. Prions rapidly remodel good protein into bad, Brown study shows
4. Prion find points way to test for human mad cow disease
5. Neuronal traffic jam marks early Alzheimers disease
6. Scientists detect probable genetic cause of some Parkinsons disease cases
7. Ecological destruction fuels emerging diseases
8. Newly discovered virus linked to childhood lung disorders and Kawasaki disease
9. U of M researcher examines newly emerging deadly disease
10. Marburg virus disease in Angola - update
11. Molecular machine may lead to new drugs to combat human diseases
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Prion disease treatable caught early

Breaking Biology News(10 mins):Brooding fishes take up nutrients from their own children 2Plate-eating good: Université de Montréal professor designs edible tableware 2Study finds new relationship between gene duplication and alternative splicing in plants 2Study finds new relationship between gene duplication and alternative splicing in plants 3IMAGINE Software Unveils Advanced IMAGINEradiology 28TM 29 Features 47841 1IMAGINE Software Unveils Advanced IMAGINEradiology 28TM 29 Features 47841 2MEDRAD Introduces Manage Report Advances Evidence Based Decision Making 47836 1MEDRAD Introduces Manage Report Advances Evidence Based Decision Making 47836 2MEDRAD Introduces Manage Report Advances Evidence Based Decision Making 47836 3New From the Heinz Family Philanthropies 3A 10 Questions and Valuable Answers to Help Families Manage Long Term Care 47831 1New From the Heinz Family Philanthropies 3A 10 Questions and Valuable Answers to Help Families Manage Long Term Care 47831 2New From the Heinz Family Philanthropies 3A 10 Questions and Valuable Answers to Help Families Manage Long Term Care 47831 3New From the Heinz Family Philanthropies 3A 10 Questions and Valuable Answers to Help Families Manage Long Term Care 47831 4New From the Heinz Family Philanthropies 3A 10 Questions and Valuable Answers to Help Families Manage Long Term Care 47831 5