Navigation Links
Primitive yeast yields secrets of human cholesterol and drug metabolism

erol is essential for cell survival.

To show that Dap1 directly works with P450s and not through some other biochemical steps, Espenshade’s team tested the ability of human Dap1 protein to bind to four of the 57 known human P450 enzymes, essentially challenging Dap1 to bind to P450s that perform totally different functions in different cells as a way to see how far-reaching its control might be.

Dap1 locked on to all four P450s, including one required for clearing half of all known drugs from the body, another involved in making bile and one required for making natural steroid hormones in the adrenal glands.

“Collectively, our experiments suggest that Dap1 acts as a common regulator of cytochrome P450s in mammals,?says Espenshade.

Because Dap1 affects one particular P450 responsible for drug metabolism, Espenshade suspects that genetic variations in the genetic blueprint coding for Dap1 may provide clues to how and why different people react differently to certain drugs.

“Understanding the molecular underpinnings of so-called pharmacogenetic variation will have a big impact on the future of medicine,?he says.
'"/>

Source:Johns Hopkins Medical Institutions


Page: 1 2

Related biology news :

1. Examination of internal wiring of yeast, worm, and fly reveals conserved circuits
2. Navigating an integrated yeast network
3. After the yeast is gone bacteria continue to develop flavor of sparkling wine
4. GlycoFi announces the first production of antibodies with human glycosylation in yeast
5. From a lowly yeast, researchers divine a clue to human disease
6. GlycoFi and Dartmouth report full humanization of yeast glycosylation pathway in Science
7. Engineered yeast speeds ethanol production
8. Hives ferment a yeasty brew, attract beetle pest
9. Genome-wide mouse study yields link to human leukemia
10. Marine sponge yields nanoscale secrets
11. Small worm yields big clue on muscle receptor action
Post Your Comments:
(Date:7/25/2014)... factor characterized by the existence of numerous isoforms ... to the protein deeply different characteristics. NRG1 plays ... during development and the different phases occurring after ... regrowth, remyelination and target reinnervation, Researchers at the ... soluble NRG1 upregulation observed in Schwann cells immediately ...
(Date:7/25/2014)... tractography (DTT), which is derived from diffusion tensor ... motor tracts, such as the corticospinal tract, the ... The corticospinal tract is known to be a ... human brain. Several studies have reported on injury ... addition, some studies have demonstrated recovery of a ...
(Date:7/25/2014)... MOResearchers at the Stowers Institute for Medical Research ... pheromone receptors, and found pheromones crucial to triggering the ... of receptors helps a male mouse detect pheromones that ... of receptors lets him know if the female mouse ... pheromones are critical to trigger mating. Stowers, researchers believe ...
Breaking Biology News(10 mins):It takes two to court 2It takes two to court 3
... technologies are repairing the human body in ways never ... leaving an increasing population of patients who are newly ... have become a formidable clinical opponent, and foremost among ... a new text from ASM Press. "This ...
... This Christmas season, think twice about spending money on ... good, old-fashioned methodkeeping your tree in a container of ... tree green and healthy. Researchers have determined that some ... fact, in several cases the chemical retardants sped up ...
... In light of recent developments that threaten to lead to ... daily satellite images of the ice shelf available to the ... to monitor the developments as they occur. The Wilkins ... coast of the Antarctic Peninsula, has undergone many changes in ...
Cached Biology News:New text focuses on formidable opportunistic fungus 2Flame retardants prove ineffective on fresh-cut Christmas trees 2
(Date:7/26/2014)... Canada Endoscopy Visualization Systems Market Outlook ... Canada Endoscopy Visualization Systems market. The report provides ... units) and average prices (in US dollars) within ... Endoscopy Visualization Systems and Low-End Endoscopy Visualization Systems. ... , The report also provides company shares and ...
(Date:7/25/2014)... bacteria live in each person,s digestive tract. Scientists believe ... stave off harmful infections, but their role in human ... light on the role of these bacteria, a team ... recently tracked fluctuations in the bacterial populations of two ... in the July 25 issue of the journal ...
(Date:7/25/2014)... New York (PRWEB) July 25, 2014 ... Market Research, "Biological Drugs Market - Global Industry Analysis, ... the global biological drugs market is estimated at USD ... at a CAGR of 10.1% from 2014 to 2020, ... in 2020. , The biological drugs market is witnessing ...
(Date:7/25/2014)... Livermore, California (PRWEB) July 25, 2014 ... been named to Thomson Reuters list of " The ... Pitz are part of the 3,000 researchers who were ... years to recognize those who published the highest-impact work ... numerous research papers on combustion modeling . , ...
Breaking Biology Technology:Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 2Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 3Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 4Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 5Monitoring the rise and fall of the microbiome 2Monitoring the rise and fall of the microbiome 3Biological Drugs Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Biological Drugs Market: Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3Scientists Burst onto Influential List for Combustion Research 2Scientists Burst onto Influential List for Combustion Research 3Scientists Burst onto Influential List for Combustion Research 4
... is a missing link in the capital food chain, and Bill ... devoured by it. , ,Payne, an entrepreneur-in-residence for the Kauffman ... to address the June 25 Wisconsin Alumni Research Foundation's ... the capital food chain for entrepreneurs, and he's familiar with all ...
... have pleaded guilty in Milwaukee to charges of criminal ... $6 million in counterfeit Rockwell Automation computer ... Alice Fisher for the Criminal Division and U.S. Attorney ... announced that Robert Koster of Jonesboro, Ark. pleaded ...
... print still captures the imagination of consumers - even consumers ... clearer example than Blurb . I first discussed Blurb ... than a brief PowerPoint deck. We met at ... unwound a vision for consumer-generated books that well pre-dates the ...
Cached Biology Technology:Investor warns of angel-venture funding gap 2Investor warns of angel-venture funding gap 3Two convicted of selling $6 million in counterfeit Rockwell software on eBay 2Blurb shows that print still captures imaginations 2Blurb shows that print still captures imaginations 3
...
...
... monoclonal [F30 P7 D7 F5] to ... tested applications). Antigen: ... Ovalbumin, corresponding to amino acids 462 ... Entrez Gene ID: 6259 ...
Pancreatic Cell Cryopreservation Medium (2X) is intended for the cryopreservation of LT2 Immortalized Pancreatic Mesenchymal Cells (SCR013) and VIT1 Primary Pancreatic Mesenchymal Cells (SCR014)....
Biology Products: