Navigation Links
Primitive yeast yields secrets of human cholesterol and drug metabolism

erol is essential for cell survival.

To show that Dap1 directly works with P450s and not through some other biochemical steps, Espenshade’s team tested the ability of human Dap1 protein to bind to four of the 57 known human P450 enzymes, essentially challenging Dap1 to bind to P450s that perform totally different functions in different cells as a way to see how far-reaching its control might be.

Dap1 locked on to all four P450s, including one required for clearing half of all known drugs from the body, another involved in making bile and one required for making natural steroid hormones in the adrenal glands.

“Collectively, our experiments suggest that Dap1 acts as a common regulator of cytochrome P450s in mammals,?says Espenshade.

Because Dap1 affects one particular P450 responsible for drug metabolism, Espenshade suspects that genetic variations in the genetic blueprint coding for Dap1 may provide clues to how and why different people react differently to certain drugs.

“Understanding the molecular underpinnings of so-called pharmacogenetic variation will have a big impact on the future of medicine,?he says.
'"/>

Source:Johns Hopkins Medical Institutions


Page: 1 2

Related biology news :

1. Examination of internal wiring of yeast, worm, and fly reveals conserved circuits
2. Navigating an integrated yeast network
3. After the yeast is gone bacteria continue to develop flavor of sparkling wine
4. GlycoFi announces the first production of antibodies with human glycosylation in yeast
5. From a lowly yeast, researchers divine a clue to human disease
6. GlycoFi and Dartmouth report full humanization of yeast glycosylation pathway in Science
7. Engineered yeast speeds ethanol production
8. Hives ferment a yeasty brew, attract beetle pest
9. Genome-wide mouse study yields link to human leukemia
10. Marine sponge yields nanoscale secrets
11. Small worm yields big clue on muscle receptor action
Post Your Comments:
(Date:8/3/2015)... JOSE, Calif. , Aug. 3, 2015 ... of human interface solutions, today announced that members of ... community at the Pacific Crest Global Technology Leadership Forum ... Time. The conference will be held at the Sonnenalp ... The presentation may include forward-looking information. An ...
(Date:7/31/2015)... de julio de 2015 La 10 th ... por medio de BGI del 22 al 25 de octubre de ... Este año, la conferencia celebra su décimo aniversario. Desde ... en una de las reuniones anuales más influyentes del mundo ... reuniones más dinámicas, entusiastas y mejores a nivel científico. ...
(Date:7/27/2015)... , July 27, 2015  Synaptics Inc. ... human interface solutions, today announced that Huawei has ... touchscreen solution for its stylish smartwatch. Huawei chose ... proven reliability, low power and highly responsive human ... finger. Huawei designers also required a classic round ...
Breaking Biology News(10 mins):La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 2La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 3Synaptics Touchscreen Solution Powers New Huawei Watch 2Synaptics Touchscreen Solution Powers New Huawei Watch 3
... in Oregon,s Willamette Basin to protect at-risk animals won,t ... will absorb more carbon from the atmosphere and vice ... study, to be published this month in the ... hypothetical payments that were given to landowners to voluntarily ...
... UC San Diego are collaborating with scientists from ... map patterns of biodiversity and land use in ... with climate models, will project how climate change ... for setting aside conservation easements. Wildlife, people ...
... Francisco Gonzlez, president of the BBVA Foundation: "One of the ... the environment and, especially, of biodiversity. This is a task ... all play our part. At BBVA, we believe it is ... of the natural resource base" United States researchers ...
Cached Biology News:Incentives for carbon sequestration may not protect species 2Biodiversity maps developed by UCSD scientists will help guide conservation measures in East Africa 2Biodiversity maps developed by UCSD scientists will help guide conservation measures in East Africa 3BBVA Foundation Awards for Biodiversity Conservation 2BBVA Foundation Awards for Biodiversity Conservation 3BBVA Foundation Awards for Biodiversity Conservation 4
(Date:8/3/2015)... , ... August 03, 2015 , ... Nine field days ... Illinois and Indiana. Hosted by the Soil Health Partnership , the field days ... environmental benefits while potentially increasing farm productivity and income. , Brent Bible has practiced ...
(Date:8/3/2015)... 2015 E-QURE Corp. (OTCQB: EQUR), ... Bio-electrical Signal Therapy device ("BST Device"), a new and ... heal chronic wounds, today announced that the Company has ... distributor specializing in medical devices, for the marketing and ... a 70 years old, sales, marketing and distribution company ...
(Date:8/3/2015)... -- According to a new market report ... Asia to Witness Highest Growth by ... culture market was valued at US$ 586.1 Mn in 2014 ... 29.1% to account for US$ 2,717.6 Mn by 2020. ... 3D cell culture refers to a process ...
(Date:8/3/2015)... ... 2015 , ... Sterlitech Corporation introduces the compact, quiet, and ... laboratory equipment. With optimized features, such as PTFE-coated contact surfaces, an oil-free design, ... solution for a broad range of vacuum filtration applications. , Featuring a 1/7 ...
Breaking Biology Technology:Soil Health Field Days Kick Off Throughout Midwest 2Soil Health Field Days Kick Off Throughout Midwest 3E-QURE Corp Signs Second Distribution Agreement in Israel 2E-QURE Corp Signs Second Distribution Agreement in Israel 3Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 2Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 3Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 4Sterlitech Launches New Line of Vacuum Pumps 2
... June 30, 2011 Dendreon Corporation (Nasdaq: ... support broad availability for on-label use of PROVENGE® ... treatment of asymptomatic or minimally symptomatic metastatic castrate ... The U.S. Food and Drug ...
... 2011 ( HCCS ) Health Care Compliance Strategies, ... competency training, today announced the release of an update ... SimPL - The Simple Platform for Learning. This ... existing online training and eLearning functions. (Logo: ...
... National Parkinson Foundation (NPF) has awarded more than $1 ... individual investigators awards program, NPF is supporting work to advance ... biomarker study, 2) a clinical trial to treat memory impairment, ... for sleep apnea in PD. "Each of these ...
Cached Biology Technology:Dendreon Announces Increased Capacity and Significant Reimbursement Decisions Supporting Broad Availability of PROVENGE 2Dendreon Announces Increased Capacity and Significant Reimbursement Decisions Supporting Broad Availability of PROVENGE 3Dendreon Announces Increased Capacity and Significant Reimbursement Decisions Supporting Broad Availability of PROVENGE 4HCCS Releases Classroom Management Features for Low Cost Learning Management System 2National Parkinson Foundation Awards More Than $1 Million for Research 2National Parkinson Foundation Awards More Than $1 Million for Research 3
Mycoplasma and virus tested...
Bethyl Laboratories Ready-To-Use IHC Bluing Reagent is used following IHC hematoxylin counterstaining with immunohistochemical procedures. Shelf-Life: 1 year from date of receipt...
Edited by Benjamin Lewin (1997) • This book gives an integrated account of the structure and function of genes in both prokaryotic organisms and is thoroughly up to date with the latest thinking...
... is the most effective ... PCR products. TOPO TA ... TOPO vectors are supplied ... topoisomerase I. This enables ...
Biology Products: