Navigation Links
Prevention is the best option: fighting autoimmune diseases

Centenary scientist Associate Professor Barbara Fazekas de St. Groth, a leader in inflammatory bowel disease research, has demonstrated for the firsttime the important role of T cells in the prevention of autoimmune diseases in humans.

In a study involving 38 patients with Crohn's disease and ulcerative colitis, the two common forms of inflammatory bowel disease (IBD), and 43 healthy controls, Assoc Prof Fazekas and colleagues found that healthy individuals have up totwice the number of disease-fighting regulatory T cells compared with IBDpatients at the onset of disease.

"It is important to have more regulatory T cells, especially when you are young, as individuals with a deficiency are more susceptible to disease and frequency of diseaseis higher in the young," says Assoc Prof Fazekas.

"Our results also indicate that the activity of these cells is increased in IBD patients during the later stages of disease in an attempt to fight it."

IBD is usually diagnosed in children and young adults. It affects 1 in 200 people and an estimated 100,000 Australians and there is no cure.

"Regulatory T cells have previously been difficult to quantify in humans and conventional methods could identify fewer than a third of the total number. The blood test we have developed allows us for the first time to accurately count thenumber of regulatory T cells in the body," says Assoc Prof Fazekas.

The highly accurate identification and isolation of regulatory T cells was made possible using sophisticated flow cytometry equipment at the Centenary Institute.

The machines use laser beams and advanced optics and electronics toanalyse and purify many kinds of cells at a rate of over 25,000 cells every second. This technology is able to produce results that cannot be obtained by any other method as it allows every cell to be identified and sorted on an individual basis.

"The ability to detect regulatory T cell deficits in inflammato ry diseases such as IBD means that we can now identify individuals at risk of developing disease. The test can also be used to assess the effect of new preventative treatments in the future."

The researchers are using the test to study regulatory T cell levels in autoimmune, inflammatory and allergic diseases such as multiple sclerosis, Type 1 diabetes, rheumatoid arthritis, asthma and eczema, to determine the risk of disease in patients and their families.


Source:Research Australia

Related biology news :

1. NYCs First Rapid HIV Drug-resistant AIDS Case Prompts Call to Step Up HIV Prevention
2. Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries
3. Researchers find promising cancer-fighting power of synthetic cell-signaling molecule
4. Experiment station researchers to explore genome of disease-fighting fungus
5. Bacterial genome sheds light on synthesizing cancer-fighting compounds
6. Anthrax stops body from fighting back, study shows
7. Scientists develop fungus-fighting vaccine
8. Radioactive scorpion venom for fighting cancer
9. UVa researchers seek to unlock broccolis cancer fighting secret
10. Hope for major advance in fighting world killer disease
11. Unique tomatoes tops in disease-fighting antioxidants
Post Your Comments:

(Date:11/18/2015)... York , November 18, 2015 ... Research has published a new market report titled  Gesture ... Trends, and Forecast, 2015 - 2021. According to the report, ... 2014 and is anticipated to reach US$29.1 bn by ... 2021. North America dominated ...
(Date:11/17/2015)... 2015 Pressure BioSciences, Inc. (OTCQB: PBIO) ("PBI" ... sale of broadly enabling, pressure cycling technology ("PCT")-based sample ... announced it has received gross proceeds of $745,000 from ... (the "Offering"), increasing the total amount raised to date ... closings are expected in the near future. ...
(Date:11/12/2015)... 11, 2015   Growing need for low-cost, ... has been paving the way for use of ... discrete analytes in clinical, agricultural, environmental, food and ... used in medical applications, however, their adoption is ... to continuous emphasis on improving product quality and ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... 2015 Studies reveal the differences ... and pave the way for more effective treatment for one ...   --> --> ... problems in cats, yet relatively little was understood about the ... have been conducted by researchers from the WALTHAM Centre for ...
(Date:11/25/2015)... IN (PRWEB) , ... November 25, 2015 , ... ... (AMA) and the Organization of Black Aerospace Professionals (OPBAP) has been formalized with ... and other AMA team leaders met with OPBAP leaders Capt. Karl Minter and ...
(Date:11/24/2015)... , Nov. 24, 2015  Asia-Pacific (APAC) ... research organisation (CRO) market. The trend of outsourcing ... lower margins but higher volume share for the ... and scale, however, margins in the CRO industry ... (CRO) Market ( ), finds that ...
(Date:11/24/2015)... , Nov. 24, 2015 /CNW/ - iCo Therapeutics ("iCo" ... reported financial results for the quarter ended September ... in Canadian dollars and presented under International Financial ... States ," said Andrew Rae , ... regarding iCo-008 are not only value enriching for ...
Breaking Biology Technology: