Navigation Links
Prevention is the best option: fighting autoimmune diseases

Centenary scientist Associate Professor Barbara Fazekas de St. Groth, a leader in inflammatory bowel disease research, has demonstrated for the firsttime the important role of T cells in the prevention of autoimmune diseases in humans.

In a study involving 38 patients with Crohn's disease and ulcerative colitis, the two common forms of inflammatory bowel disease (IBD), and 43 healthy controls, Assoc Prof Fazekas and colleagues found that healthy individuals have up totwice the number of disease-fighting regulatory T cells compared with IBDpatients at the onset of disease.

"It is important to have more regulatory T cells, especially when you are young, as individuals with a deficiency are more susceptible to disease and frequency of diseaseis higher in the young," says Assoc Prof Fazekas.

"Our results also indicate that the activity of these cells is increased in IBD patients during the later stages of disease in an attempt to fight it."

IBD is usually diagnosed in children and young adults. It affects 1 in 200 people and an estimated 100,000 Australians and there is no cure.

"Regulatory T cells have previously been difficult to quantify in humans and conventional methods could identify fewer than a third of the total number. The blood test we have developed allows us for the first time to accurately count thenumber of regulatory T cells in the body," says Assoc Prof Fazekas.

The highly accurate identification and isolation of regulatory T cells was made possible using sophisticated flow cytometry equipment at the Centenary Institute.

The machines use laser beams and advanced optics and electronics toanalyse and purify many kinds of cells at a rate of over 25,000 cells every second. This technology is able to produce results that cannot be obtained by any other method as it allows every cell to be identified and sorted on an individual basis.

"The ability to detect regulatory T cell deficits in inflammato ry diseases such as IBD means that we can now identify individuals at risk of developing disease. The test can also be used to assess the effect of new preventative treatments in the future."

The researchers are using the test to study regulatory T cell levels in autoimmune, inflammatory and allergic diseases such as multiple sclerosis, Type 1 diabetes, rheumatoid arthritis, asthma and eczema, to determine the risk of disease in patients and their families.


'"/>

Source:Research Australia


Related biology news :

1. NYCs First Rapid HIV Drug-resistant AIDS Case Prompts Call to Step Up HIV Prevention
2. Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries
3. Researchers find promising cancer-fighting power of synthetic cell-signaling molecule
4. Experiment station researchers to explore genome of disease-fighting fungus
5. Bacterial genome sheds light on synthesizing cancer-fighting compounds
6. Anthrax stops body from fighting back, study shows
7. Scientists develop fungus-fighting vaccine
8. Radioactive scorpion venom for fighting cancer
9. UVa researchers seek to unlock broccolis cancer fighting secret
10. Hope for major advance in fighting world killer disease
11. Unique tomatoes tops in disease-fighting antioxidants
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/15/2016)... 2016 Transparency Market Research ... Market by Application Market - Global Industry Analysis Size Share ... the report, the  global gesture recognition market  was ... is estimated to grow at a CAGR of ... Increasing application of gesture recognition technology ...
(Date:6/2/2016)... , June 2, 2016 The ... has awarded the 44 million US Dollar project, for ... Embossed Vehicle Plates including Personalization, Enrolment, and IT Infrastructure ... leader in the production and implementation of Identity Management Solutions. ... January, however Decatur was selected for ...
(Date:5/20/2016)... MINNEAPOLIS , May 20, 2016  VoiceIt ... technology partnership with VoicePass. By working ... user experience.  Because VoiceIt and VoicePass take slightly ... two engines increases both security and usability. ... expressed excitement about this new partnership. ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... CA (PRWEB) , ... June 27, 2016 , ... ... for clinical trials, announced today the Clinical Reach Virtual Patient Encounter CONSULT ... care circle with the physician and clinical trial team. , Using the CONSULT module, ...
(Date:6/27/2016)... June 27, 2016   Ginkgo Bioworks , a ... engineering, was today awarded as one of the ... the world,s most innovative companies. Ginkgo Bioworks is ... the real world in the nutrition, health and ... directly with customers including Fortune 500 companies to ...
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita Politecnica delle Marche ... with peritoneal or pleural mesothelioma. Their findings are the subject of a new article ... Diagnostic biomarkers are signposts in the blood, lung fluid or tissue of mesothelioma patients ...
(Date:6/23/2016)... June 23, 2016 /PRNewswire/ - FACIT has announced ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" ... commercialization of a portfolio of first-in-class WDR5 inhibitors ... such as WDR5 represent an exciting class of ... precision medicine for cancer patients. Substantial advances have ...
Breaking Biology Technology: