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Predicting successful outcomes in living-donor liver transplants

onors and recipients after LDLT than conventional liver function tests indicate," the authors conclude.

In an accompanying editorial, Jürg Reichen, M.D., of the University Hospital, University of Berne in Switzerland notes that ICG clearance as measured in the first study can predict poor outcomes and might be useful for LDLT recipients, while the second study points out that liver regeneration might not be complete for donors, even though the liver achieves its full size within four weeks of transplant. "Whether the about 10 percent loss of function compared to preoperative values will translate into clinically relevant impairment of liver function ?in particular with respect to drug metabolism as suggested by the authors ?has yet to be determined," he states. He also notes that the multiple blood sampling used by the second study is quite labor intensive when compared to the device used in the first study, which is more apt to make its way into clinical practice. He concludes: "Before clinical decisions are based upon any of these tests, however, confirmation of the findings in larger patient populations in prospective studies are needed."


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Source:John Wiley & Sons, Inc.


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