Navigation Links
Predicting chemotherapy outcome

Studying the gene-expression profiles of patients with colorectal cancer might help predict their response to chemotherapy. In a study published today in the open access journal Genome Biology, researchers identified in the tumours of colorectal cancer patients almost 700 genes whose expression was different between patients who subsequently responded well to combined chemotherapy and patients who were resistant to the therapy. These findings could be used in clinical practice to complement clinical, biochemical and genetic markers for better treatment of patients with colorectal cancer.

A research group led by Sandrine Imbeaud from the CNRS and Pierre and Marie Curie University, Villejuif, France, used microarrays to analyse the gene-expression patterns of samples from colon tumours and liver metastases collected from 13 patients with colorectal cancer. The microarray analyses were carried out before the patients were treated with combined chemotherapy of folinic acid, 5-fluorouracil and irinotecan.

Imbeaud and colleagues identified 679 genes that were differently expressed in patients who subsequently responded well to chemotherapy compared with patients who were resistant to the therapy. The results were validated by RT-PCR analysis, which confirmed the differential expression of 22 genes selected from the list. The findings were also confirmed by RT-PCR analysis of colon and liver tumour samples collected from two additional patients.

The authors were able to integrate their findings into global and interconnected molecular networks that characterise resistance in patients with colorectal cancer before they are exposed to chemotherapy. They conclude that knowledge of these networks could potentially be used to improve diagnosis and treatment of patients with colorectal cancer.


'"/>

Source:BioMed Central


Page: 1

Related biology news :

1. Predicting success
2. Predicting successful outcomes in living-donor liver transplants
3. USC researchers determine mechanism of action of chemotherapy drug
4. Gene expression profile helps predict chemotherapy response in ovarian cancer patients
5. New device could cut chemotherapy deaths
6. Buckyballs boost antibodys chemotherapy payload
7. Injection may prevent infertility in men receiving cancer chemotherapy
8. First-ever genomic test predicts which lung cancer patients need chemotherapy to live
9. St. Jude finds clues to hearing loss from chemotherapy
10. Researchers examine why food tastes bad to chemotherapy recipients
11. Researchers urge monitoring of bone health during chemotherapy
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... , Apr. 11, 2017 Research and ... Market 2017-2021" report to their offering. ... The global eye tracking market to grow at a ... report, Global Eye Tracking Market 2017-2021, has been prepared based on ... covers the market landscape and its growth prospects over the coming ...
(Date:4/5/2017)... , April 5, 2017  The Allen Institute ... Allen Cell Explorer: a one-of-a-kind portal and dynamic digital ... 3D imaging data, the first application of deep learning ... human stem cell lines and a growing suite of ... platform for these and future publicly available resources created ...
(Date:4/3/2017)... , April 3, 2017  Data ... precision engineering platform, detected a statistically significant ... product prior to treatment and objective response ... the potential to predict whether cancer patients ... to treatment, as well as to improve ...
Breaking Biology News(10 mins):
(Date:4/19/2017)... , ... April 18, 2017 , ... A number of ... This webinar, which is part of the Protein and Cell Analysis Education Webinar ... outline where this technology fits in current and future applications. , Many flow ...
(Date:4/19/2017)... ... April 19, 2017 , ... Nobilis Therapeutics Announces Completion of Landmark ... Clinical Data in its Upcoming Post Traumatic Stress Disorder Trial , Nobilis Therapeutics, ... trial assessing efficacy of its NBTX-001, a xenon-based therapeutic in the treatment of Panic ...
(Date:4/19/2017)... ... April 19, 2017 , ... As part of the ... to novices as well as experienced users, attendees will gain a better understanding ... tests. , Hemostasis testing quality is determined by preanalytical variables which encompass ...
(Date:4/19/2017)... and WESTMINSTER, Colo. ... LLC ("Oxford"), an industry-leading specialty finance firm that ... services companies, today announced the closing of a ... Inc. ("Cerapedics") a privately-held orthobiologics company engaged in ... products for the treatment of orthopedic injuries. ...
Breaking Biology Technology: