Navigation Links
Predicting chemotherapy outcome

Studying the gene-expression profiles of patients with colorectal cancer might help predict their response to chemotherapy. In a study published today in the open access journal Genome Biology, researchers identified in the tumours of colorectal cancer patients almost 700 genes whose expression was different between patients who subsequently responded well to combined chemotherapy and patients who were resistant to the therapy. These findings could be used in clinical practice to complement clinical, biochemical and genetic markers for better treatment of patients with colorectal cancer.

A research group led by Sandrine Imbeaud from the CNRS and Pierre and Marie Curie University, Villejuif, France, used microarrays to analyse the gene-expression patterns of samples from colon tumours and liver metastases collected from 13 patients with colorectal cancer. The microarray analyses were carried out before the patients were treated with combined chemotherapy of folinic acid, 5-fluorouracil and irinotecan.

Imbeaud and colleagues identified 679 genes that were differently expressed in patients who subsequently responded well to chemotherapy compared with patients who were resistant to the therapy. The results were validated by RT-PCR analysis, which confirmed the differential expression of 22 genes selected from the list. The findings were also confirmed by RT-PCR analysis of colon and liver tumour samples collected from two additional patients.

The authors were able to integrate their findings into global and interconnected molecular networks that characterise resistance in patients with colorectal cancer before they are exposed to chemotherapy. They conclude that knowledge of these networks could potentially be used to improve diagnosis and treatment of patients with colorectal cancer.


'"/>

Source:BioMed Central


Page: 1

Related biology news :

1. Predicting success
2. Predicting successful outcomes in living-donor liver transplants
3. USC researchers determine mechanism of action of chemotherapy drug
4. Gene expression profile helps predict chemotherapy response in ovarian cancer patients
5. New device could cut chemotherapy deaths
6. Buckyballs boost antibodys chemotherapy payload
7. Injection may prevent infertility in men receiving cancer chemotherapy
8. First-ever genomic test predicts which lung cancer patients need chemotherapy to live
9. St. Jude finds clues to hearing loss from chemotherapy
10. Researchers examine why food tastes bad to chemotherapy recipients
11. Researchers urge monitoring of bone health during chemotherapy
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/26/2016)... DUBLIN , April 27, 2016 ... of the  "Global Multi-modal Biometrics Market 2016-2020"  report ... ) , The analysts forecast ... a CAGR of 15.49% during the period 2016-2020.  ... a number of sectors such as the healthcare, ...
(Date:4/15/2016)... , April 15, 2016  A new ... make more accurate underwriting decisions in a fraction ... timely, competitively priced and high-value life insurance policies ... screenings. With Force Diagnostics, rapid testing ... lifestyle data readings (blood pressure, weight, pulse, BMI, ...
(Date:4/14/2016)... 2016 BioCatch ™, the ... announced the appointment of Eyal Goldwerger as ... Goldwerger,s leadership appointment comes at a time of ... deployment of its platform at several of the world,s ... discerns unique cognitive and physiological factors, is a winner ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... Columbia , April 27, 2016 ... "NanoStruck") (CSE: NSK) (OTCPink: NSKQB) ( Frankfurt ... Anschluss an ihre Pressemitteilung vom 13. August 2015 ... hat, ihre Finanzen um zusätzliche 200.000.000 Einheiten auf ... Kanadische Dollar zu bringen. Davon wurden 157.900.000 Einheiten ...
(Date:4/27/2016)... ... April 27, 2016 , ... A compact ... Emission Tomography) and MRI (Magnetic Resonance Imaging) in existing third-party MRI systems. PET ... treatments in small animal subjects. Simultaneous PET/MRI imaging offers a solution to many ...
(Date:4/26/2016)... ... April 27, 2016 , ... ... Roca Rothgerber Christie LLP as an associate in the firm’s Intellectual Property practice ... electrical, mechanical and electromechanical patent applications. He has an electrical engineering and computer ...
(Date:4/26/2016)... ... April 26, 2016 , ... This unique "Fertility Happy Hour" ... offer attendees an opportunity to get the lowdown on female fertility and the reproductive ... appetizers, Dr. Jesse Hade, of Boston IVF - The Arizona Center, will give a ...
Breaking Biology Technology: