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Precise Timing Enabled Pig-to-rat Transplants To Cure Diabetes

part of the pancreas, where insulin is made, is different.

"There are no structures similar to the islets of Langerhans, only individual endocrine cells engrafted in the omentum. This is a perfect place for them to release insulin where it will do the most good -- directly into a key blood vessel known as the portal vein," Hammerman explains.

In a collaboration with scientists at the University of Alabama-Birmingham, Hammerman has received funding from the Juvenile Diabetes Research Foundation to transplant pig pancreatic primordia into diabetic primates. If the pig-to-primate work is successful, he hopes to move on to human trials.

Rogers SA, Liapis H, Hammerman MR. Normalization of glucose post-transplantation of pig pancreatic anlagen into non-immunosuppressed rats depends on obtaining anlagen prior to embryonic day 35. Transplant Immunology, vol. 15, issue 1, Sept. 2005.


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Source:Washington University School of Medicine


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