Navigation Links
Precise Timing Enabled Pig-to-rat Transplants To Cure Diabetes

membrane that envelopes the intestines and other digestive organs. When the primordia mature, they replace the missing rat insulin with pig insulin, returning the rats' blood glucose to normal levels.

"The absence of a need for immune suppression after transplanting from one species to another was such an unexpected and encouraging discovery that we wanted to find out more about why that worked and under what conditions it is possible," Hammerman says.

Superficially, there appears to be relatively little difference between pancreatic primordia from 28-day-old and 35-day-old pig embryos. "To put this in perspective, pig gestation is about 120 days, and it takes every bit of that time for the pancreas to fully develop," Hammerman explains. "There is no pancreas before embryonic day 28, and 35-day-old pancreas is still very early-stage tissue."

Hammerman and Rogers have demonstrated that the pancreatic transplants aren't altering the rats' immune systems. They showed that rats with successful pancreatic transplants still reject a transplant of a different type of pig primordia, embryonic kidney tissue, if they are not given immune suppression drugs.

Prior research by other scientists into the immune system's interactions with transplants had suggested that a second unsuccessful organ transplant can "wake up" the immune system and lead it to reject an earlier successful transplant of a different organ. However, this didn't happen in the rats that rejected secondary kidney transplants.

To Hammerman, this suggests that the pancreatic primordia may be effectively invisible to the rat's immune system. He theorizes that this invisibility is a result of the unusual ways 28-day-old tissues differentiate after transplantation. He and Rogers have shown that no part of the digestive components of the pancreas, which are not needed to treat diabetes, develops after cross-species transplantation of such primordia.

Even the endocrine
'"/>

Source:Washington University School of Medicine


Page: 1 2 3

Related biology news :

1. Surgical Robot Scrubs In At UNC, May Be More Precise Than Conventional Surgery
2. Timing is everything: First step in protein building revealed
3. FDA Approves New Drug to Treat Type I and Type II Diabetes
4. First North American Encapsulated Islet Transplant without Long-term Immune Suppression into a Patient with Type 1 Diabetes
5. Single-donor Islet Transplantation Procedure Shows Promise For Patients With Type 1 Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Precise Timing Enabled Pig rat Transplants Cure Diabetes

(Date:5/21/2015)... , May 21, 2015 ... "Thermal Imaging Market by Solutions (Hardware, Software, Services), by ... Automotive & others), by End-Users (Military & Defense ... by MarketsandMarkets, Thermal Imaging Market is expected to ... Million by 2020, at a Compound Annual Growth ...
(Date:5/19/2015)... -- Technology is rapidly advancing, outpacing enterprises, ability to secure ... and their management are soon to be rendered obsolete ... as those developed by the FIDO Alliance™. With the ... BYOD, COPE, IoT, and mobile payments, the interconnected online ... In response to the call for seamless, secure, ...
(Date:5/11/2015)... SAN JOSE, Calif. , May 11, 2015 ... leading developer of human interface solutions, today announced ... Senior Vice President and Chief Financial Officer, reporting ... Mr. Ali replaces Synaptics, current Chief Financial Officer, ... in December 2014. Mr. Ali ...
Breaking Biology News(10 mins):Thermal Imaging Market Worth $9,998.9 Million by 2020 2Thermal Imaging Market Worth $9,998.9 Million by 2020 3Thermal Imaging Market Worth $9,998.9 Million by 2020 4HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 2HYPR Corp. Biometric Security Integration Kit Shields Applications and Devices Across the Internet of Things 3Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2
... AWRE ), a leading technology innovator and supplier ... call to discuss the company,s operating results for the third ... Eastern Time. President and CEO Edmund Reiter and CFO Rick ... call is being webcast by Thomson and can be accessed ...
... slice it, watermelon has a lot going for it ... there,s more. Evidence from a pilot study led by food ... be an effective natural weapon against prehypertension, a precursor to ... its kind in humans. FSU Assistant Professor Arturo Figueroa and ...
... ,URBANA When you think about "wine country," Illinois may not ... big business on the prairie. There are 90 wineries licensed in ... wine grapes can bring as much as $8,000 in sales, though ... produce 90,000 gallons per year, while many produce 3,000 to 10,000 ...
Cached Biology News:Aware, Inc. Announces Q3'10 Earnings Conference Call 2Florida State study finds watermelon lowers blood pressure 2Florida State study finds watermelon lowers blood pressure 3Taming wild grapes for better wine 2Taming wild grapes for better wine 3
(Date:5/20/2015)... 2015  Select Medical Corporation ("Select") (NYSE: ... granted early termination of the waiting period under ... as amended, applicable to the acquisition of Concentra ... venture that Select has created with Welsh, Carson, ... announced, MJ Acquisition Corporation has signed a definitive ...
(Date:5/20/2015)... Agricultural firm H.J. Baker & Bro., ... of Tiger-Sul. Since the purchase of Tiger Industries ... May 2005, H.J. Baker has leveraged the innovation of ... comprehensive portfolio of product offerings and solutions expertise. The ... the innovation of Tiger-Sul, transforming the company into a ...
(Date:5/20/2015)... DIEGO , May 20, 2015  Cypher ... announced a collaboration with Celgene Corporation to apply ... genomic biomarkers that associate with patient response to ... is intended to help accelerate patient access to ... efficiencies in clinical research and development and potentially ...
(Date:5/20/2015)... RESEARCH TRIANGLE PARK, North Carolina ... das weltweit führende Unternehmen für klinische ... geprüften Finanzergebnisse für das Geschäftsjahr 2014, ... abgeschlossen und eingereicht. Das Unternehmen hat ... abgeschlossen. Logo - ...
Breaking Biology Technology:Select Medical Corporation's Proposed Acquisition of Concentra Inc. through Joint Venture with Welsh Carson Receives Antitrust Clearance 2Agricultural Firm H.J. Baker & Bro., Inc., Celebrates 10 Years Since Acquisition Of Tiger-Sul 2Agricultural Firm H.J. Baker & Bro., Inc., Celebrates 10 Years Since Acquisition Of Tiger-Sul 3Cypher Genomics Collaborates with Celgene Corporation to Identify Novel Genomic Biomarkers 2Marken schließt Ergebnisse für das Geschäftsjahr 2014 ab 2
... , SAN DIEGO, Dec. 10 Biomatrica, the ... release of SampleWare 3.1 software system for laboratory inventory, organization ... an audit trail functionality that tracks user and date stamps ... , The addition of the audit trail feature offers ...
... ... center in the country specifically established to treat adolescents and adults and is today the ... in its registry. , ... December 10, 2009 -- The Hertz Family Foundation of Santa Monica has announced that total ...
... Opinion Leaders Examine the Role ... Dec. 9 On Tuesday, December 8, 2009, Scientific American , the ... Decade-2 Education Forum in Washington, D.C. The forum was ... was sponsored by Amgen , a leading biotechnology company committed to science ...
Cached Biology Technology:Biomatrica Launches SampleWare 3.1 2Biomatrica Launches SampleWare 3.1 3Hertz Annual Appeal for Adult Congenital Heart Disease Center At UCLA Passes $2-Million Mark in Funds Raised Over Ten Years 2Hertz Annual Appeal for Adult Congenital Heart Disease Center At UCLA Passes $2-Million Mark in Funds Raised Over Ten Years 3Science Education Experts Discuss Solutions for Global Competitiveness at Scientific American Forum 2Science Education Experts Discuss Solutions for Global Competitiveness at Scientific American Forum 3
... reliable and compact GC-8A is Shimadzu's basic ... and simple to use, the GC-8A supports ... control, on column injection port(s), and analog ... models are available. The GC-8A is only ...
... system combines world-class performance hardware, Cerity Networked ... world-renowned support and columns, as well as ... that lets you reach uncompromising results and ... data. The Agilent 6820 GC system is ...
... Adding an exciting new chapter ... GC leadership, Agilents 7890A GC ... to take your lab to ... and GC/MS performance, including advanced ...
The essence of fluorescence analysis is sensitivity. The high throughput optical system in the RF-5301PC employs a blazed holographic grating, photomultiplier and digital signal processing to provide...
Biology Products: