Navigation Links
Precise Timing Enabled Pig-to-rat Transplants To Cure Diabetes

membrane that envelopes the intestines and other digestive organs. When the primordia mature, they replace the missing rat insulin with pig insulin, returning the rats' blood glucose to normal levels.

"The absence of a need for immune suppression after transplanting from one species to another was such an unexpected and encouraging discovery that we wanted to find out more about why that worked and under what conditions it is possible," Hammerman says.

Superficially, there appears to be relatively little difference between pancreatic primordia from 28-day-old and 35-day-old pig embryos. "To put this in perspective, pig gestation is about 120 days, and it takes every bit of that time for the pancreas to fully develop," Hammerman explains. "There is no pancreas before embryonic day 28, and 35-day-old pancreas is still very early-stage tissue."

Hammerman and Rogers have demonstrated that the pancreatic transplants aren't altering the rats' immune systems. They showed that rats with successful pancreatic transplants still reject a transplant of a different type of pig primordia, embryonic kidney tissue, if they are not given immune suppression drugs.

Prior research by other scientists into the immune system's interactions with transplants had suggested that a second unsuccessful organ transplant can "wake up" the immune system and lead it to reject an earlier successful transplant of a different organ. However, this didn't happen in the rats that rejected secondary kidney transplants.

To Hammerman, this suggests that the pancreatic primordia may be effectively invisible to the rat's immune system. He theorizes that this invisibility is a result of the unusual ways 28-day-old tissues differentiate after transplantation. He and Rogers have shown that no part of the digestive components of the pancreas, which are not needed to treat diabetes, develops after cross-species transplantation of such primordia.

Even the endocrine
'"/>

Source:Washington University School of Medicine


Page: 1 2 3

Related biology news :

1. Surgical Robot Scrubs In At UNC, May Be More Precise Than Conventional Surgery
2. Timing is everything: First step in protein building revealed
3. FDA Approves New Drug to Treat Type I and Type II Diabetes
4. First North American Encapsulated Islet Transplant without Long-term Immune Suppression into a Patient with Type 1 Diabetes
5. Single-donor Islet Transplantation Procedure Shows Promise For Patients With Type 1 Diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Precise Timing Enabled Pig rat Transplants Cure Diabetes

(Date:11/15/2014)... , Nov. 13, 2014  While we may still be ... McCoy used in "Star Trek" to gain instant access to ... to work with smartphones and tablets for monitoring and measuring ... healthcare world. This may seem a tad Orwellian to some, ... adopt some of these technological opportunities into their healthcare regime. ...
(Date:11/7/2014)... conjunction with the Glendale and ... the Verdugos has announced the " GLENDALE - ... to keep the Verdugo Regional Crime Lab operational after its ... existence, the Lab has processed more than 400 DNA samples, ... "Because our number one priority is the wellbeing of ...
(Date:11/6/2014)... November 6, 2014 - Insilico Medicine, Inc, a ... and age related diseases announced a research collaboration ... cancer, Champions Oncology, Inc (OTC: CSBR). , "There ... personalized medicine, but Champions Oncology,s TumorGraft technology is ... the chemotherapy regimen experimentally generating vast amounts of ...
Breaking Biology News(10 mins):Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4Community Foundation Of The Verdugos Unveils Campaign To Fund Glendale-Burbank DNA Justice Project 2Insilico Medicine, Inc announces research collaboration with Champions Oncology, Inc 2
... evolve to survive climate change may depend on the ... mathematical model that simulates the effect of climate change ... early online edition of Evolutionary Applications , are ... change in the past might not be able to ...
... discovered that an active ingredient in the Persian spice saffron ... as multiple sclerosis. Chris Power and a team ... published their findings in the peer-reviewed publication, The Journal ... compound in saffron, known as crocin, that exerts a protective ...
... A new chemical process developed by a team ... Emission Tomography (PET) in creating real-time 3-D images of ... new work by Tobias Ritter, Associate Professor of Chemistry ... possibility of using PET scans to peer into any ...
Cached Biology News:Biodiversity can promote survival on a warming planet 2Medical researchers make important research link between active ingredient in saffron and MS 2Tracing biological pathways 2
(Date:11/21/2014)... USA (PRWEB) November 19, 2014 The ... our lives was shared with more than 200 primary ... postgraduate students from the University of Otago Physics Department ... . The Otago students, members of the university’s OSA/SPIE ... Zealand in early September, giving children from small, rural ...
(Date:11/21/2014)... The report, "Synthetic Biology Market by ... Technology (Bioinformatics, Nanotechnology, Gene Synthesis, Cloning & ... Global Forecast to 2018", analyses and studies ... challenges. , Browse 99 market data tables ... and in-depth TOC of the global synthetic ...
(Date:11/21/2014)... November 21, 2014 2014 Deep ... Industry” is a professional and in-depth research report ... ferrocyanide information, like its definition, classification, application, ... overview. This report covers the international market analysis, ... (such as the US, Europe, Asia, China, Japan ...
(Date:11/21/2014)... and SAN DIEGO , Nov. 20, ... announced that President and CEO Marc Hedrick , M.D. will ... DATE:   Thursday, December 4, 2014 TIME:    11:15 ... here or paste this URL into your browser,s address ... investors pre-register to save time and receive event updates. ...
Breaking Biology Technology:Optics and photonics outreach programs share science, spark fascination with light 2Optics and photonics outreach programs share science, spark fascination with light 3Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 2Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 3Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 4Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 2Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 3Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 2Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 3Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 4
... International Corporation (NASDAQ: PRXL ) announced today that ... in New York.  Josef von Rickenbach, Chairman and Chief Executive ... p.m.  ET on Wednesday, September 7, 2011.   ... Growth Stock Conference in New York.  Josef von Rickenbach, Chairman ...
... Savvier consumers and competition from generic drugs have made ... maturity, more elusive.  At the same time, new technologies ... to support pharmaceutical brand growth. While biopharma ... brands, recent field research from Best Practices, LLC suggests ...
... manufacturer of advanced cell imaging systems, today announced that the ... division of Merck KGaA of Germany.  The transaction is subject ... in the fourth quarter of 2011. The terms of the ... of USD 14 million (EUR 10 million) in 2010 and ...
Cached Biology Technology:PAREXEL International to Present at Robert Baird Healthcare Conference and William Blair Emerging Growth Stock Conference 2Using Public Relations to Launch, Grow, and Extend Pharmaceutical and Biotech Brands 2Amnis Acquired by EMD Millipore - Expands Growth Potential 2Amnis Acquired by EMD Millipore - Expands Growth Potential 3
Component of HyperMu™ Insertion Kit...
...
Request Info...
... Rabbits x 2 , ... bleed x1 /each , Immunizations/Boost injections ... (app. 5 ml) x1 /each , ... /each , Final Bleed ~ 100 ml blood ...
Biology Products: