Navigation Links
Powerful technique for multiplying adult stem cells may aid therapies

dramatically?

Zhang used a microarray platform to search for genes that were active in these newly discovered cells, but not active in similar neighboring cells. Some such genes, he reasoned, might encode secreted proteins that sustained stem cells. Eventually, he located a number of such genes.

In the fall of 2003 and early 2005, Zhang reported in the journal Blood how one of these genes codes for a growth factor protein called IGF-2. When Zhang purified IGF-2 and added it in a solution to hematopoietic stem cells that he had isolated, the stem cells increased eight-fold in number.

Zhang then discovered that two more growth factor proteins, Angiopoietin-like 2 and ?, abbreviated as angpt12 and angpt13, were also abundantly expressed in these stem-cell supporting cells. When Zhang combined these two proteins with IGF-2 and added them to hematopoietic stem cells, the result was a 30-fold increase.

"People have been culturing and working with these cells for years, and never before have we seen such an increase," says Zhang.

A 30-fold expansion, if replicated in human cells, could open up a number of doors for researchers working on adult stem cells. Currently, patients with certain blood diseases are treated with stem cells. These stem cells can be acquired either from a donor's bone marrow, or even from cord blood (donated cord blood, or the patient's own). Still, in both these cases, the actual number of stem cells from a donor often falls short of the number needed to adequately treat the patient. This technique could directly address this problem.

Gene therapy is another area where these findings can be of immediate value, Lodish says.

With gene therapy, a genetic defect is corrected by administering a healthy version of the gene into a patient. For example, a physician isolates hematopoietic stem cells from a patient, introduces a harmless virus into them that expresses a correct version of the m
'"/>

Source:Whitehead Institute for Biomedical Research


Page: 1 2 3

Related biology news :

1. Powerful new tool for studying brain development
2. Powerful genome ID method extended to humans
3. New lab technique identifies high levels of pathogens in therapy pool
4. Brain-mapping technique aids understanding of sleep, wakefulness
5. Study reveals new technique for fingerprinting environmental samples
6. Researchers pioneer new gene therapy technique using natural repair process
7. Newer imaging techniques may lead to over-treatment
8. Gene silencing technique offers new strategy for treating, curing disease
9. Mosaic mouse technique offers a powerful new tool to study diseases and genetics
10. Researchers devise new technique for creating human stem cells
11. New technique rapidly detects illness-causing bacteria
Post Your Comments:
(Date:8/28/2014)... mobile app called TX Invasives is now available from ... of Texas at Austin for identifying harmful non-native plant, ... species in the United States cause about $137 billion ... agricultural crops, clog waterways, kill native plants and more. ... app for reporting where invasive species occur, we,re more ...
(Date:8/28/2014)... German . ... to a striking pattern of blue stripes alternating with golden ... cells, and yellow cells emerge during growth in the skin ... mosaic to compose the characteristic colour pattern. ,While ... interact to form proper stripes, the embryonic origin of the ...
(Date:8/28/2014)... PAUL (August 28, 2014) Researchers at the University ... facioscapulohumeral muscular dystrophy (FSHD) to be used for muscle ... of potential therapies for FSHD. , The research is ... Cell Reports . , There is no treatment for ... most common type of muscular dystrophy. FSHD is an ...
Breaking Biology News(10 mins):Mobile app makes ID of harmful plants, insects in Texas a snap 2How the zebrafish gets its stripes 2How the zebrafish gets its stripes 3UMN researchers find animal model for understudied type of muscular dystrophy 2
... MIT neuroscientists has found that brain scans of patients ... will benefit from cognitive behavioral therapy. Social anxiety ... medications. However, it is currently impossible to predict which ... team of researchers from MIT, Boston University (BU) and ...
... release is available in German . ... Diseases (DZNE) and the University of Bonn have illuminated how ... letting the most important impulses pass," explains Remy. "This produces ... storage." How does this refined control system work? How ...
... Hachinohe, JapanScientific deep sea drilling vessel Chikyu sets a ... samples from deeper than 2,111 meters below the seafloor ... Ocean. The Japan Agency for Marine-Earth Science and Technology ... Chikyu, announced this achievement on 6th September, 2012. ...
Cached Biology News:Predicting how patients respond to therapy 2Predicting how patients respond to therapy 3A brain filter for clear information transmission 2Chikyu sets a new world drilling-depth record of scientific ocean drilling 2
(Date:8/29/2014)... Albany, New York (PRWEB) August 29, 2014 ... be valued at $5.6 billion in 2019. It ... 18.1% from 2013 to 2019, and was valued ... research report published by Transparency Market Research. , ... please visit: http://www.transparencymarketresearch.com/companion-diagnostics-market.html . , The research ...
(Date:8/29/2014)... 29, 2014 /PRNewswire/ - iCo Therapeutics ("iCo" or ... financial results for the six months ended June ... in Canadian dollars and presented under International Financial ... Highlights , Announced top-line results related ... endpoint for subjects enrolled in the Phase 2 ...
(Date:8/29/2014)... 29, 2014 Due to a misstatement posted ... the Adult Stem Cell Technology Center, LLC ( ASCTC ) ... cell therapy research that might benefit ALS patients. Because ... new stem cell technologies and therapeutic applications, FRC listed ASCTC ... Challenge donors who wish not to support research that ...
(Date:8/28/2014)... 2014 SPIE Fellow Glenn Boreman, Professor ... Science and Director of the Center for Optoelectronics and ... Charlotte, and co-founder and Chairman of the Board of ... 2015 Vice President of SPIE, the international society for ... announced recent election results at the Annual General Meeting ...
Breaking Biology Technology:Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 2Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 3iCo Therapeutics Announces Second Quarter 2014 Financial Results 2iCo Therapeutics Announces Second Quarter 2014 Financial Results 3iCo Therapeutics Announces Second Quarter 2014 Financial Results 4The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 2The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 3Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2
... Oct. 10 Wyeth (NYSE: WYE ),announced today ... (Individually,and as Administrator of the Estate of Edna Faye ... found in favor of Wyeth., "We believe this ... an attorney from Reed Smith, who represented Wyeth. "While,Mrs. ...
... Finesse Solutions, LLC, a,manufacturer of measurement and ... to announce improvements to their E-Commerce Store,that makes ... E-Store,can be found at the Finesse web site ... sensors and accessories,on-line, anywhere in the world, and ...
... Oct. 10 Twenty of Britain,s most,innovative technology ... at the fifth annual SETsquared Partnership Showcase 2008. ... George Street, London, from 8am on,Thursday, October 16th, ... information technology, engineering and biotechnology., Six companies ...
Cached Biology Technology:Creators of Britain's Innovation Economy to Showcase the Technologies of the Future at the Fifth SETsquared Partnership Showcase 2008 2Creators of Britain's Innovation Economy to Showcase the Technologies of the Future at the Fifth SETsquared Partnership Showcase 2008 3
Rabbit Polyclonal antibody to Perilipin Applications: This antibody is useful for Western blot anlaysis where a band at ~60 kDa is seen....
Conveniently document gels, films and membranes with a high quality thermal printer. , Compact, footprint printer , Supplies 256 gray scale for high resolution, archive-quality thermal film prints...
... ICE-LAP3 Mch3 Lyophilized ... of enzyme regulation and kinetics, cleavage of target substrates, ... units/mg protein. One unit is defined as ... of Ac-DEVD-pNA Cat. No. 235400 per hour at 37 ...
HLA-DRbeta (DA2)...
Biology Products: