Navigation Links
Powerful technique for multiplying adult stem cells may aid therapies

dramatically?

Zhang used a microarray platform to search for genes that were active in these newly discovered cells, but not active in similar neighboring cells. Some such genes, he reasoned, might encode secreted proteins that sustained stem cells. Eventually, he located a number of such genes.

In the fall of 2003 and early 2005, Zhang reported in the journal Blood how one of these genes codes for a growth factor protein called IGF-2. When Zhang purified IGF-2 and added it in a solution to hematopoietic stem cells that he had isolated, the stem cells increased eight-fold in number.

Zhang then discovered that two more growth factor proteins, Angiopoietin-like 2 and ?, abbreviated as angpt12 and angpt13, were also abundantly expressed in these stem-cell supporting cells. When Zhang combined these two proteins with IGF-2 and added them to hematopoietic stem cells, the result was a 30-fold increase.

"People have been culturing and working with these cells for years, and never before have we seen such an increase," says Zhang.

A 30-fold expansion, if replicated in human cells, could open up a number of doors for researchers working on adult stem cells. Currently, patients with certain blood diseases are treated with stem cells. These stem cells can be acquired either from a donor's bone marrow, or even from cord blood (donated cord blood, or the patient's own). Still, in both these cases, the actual number of stem cells from a donor often falls short of the number needed to adequately treat the patient. This technique could directly address this problem.

Gene therapy is another area where these findings can be of immediate value, Lodish says.

With gene therapy, a genetic defect is corrected by administering a healthy version of the gene into a patient. For example, a physician isolates hematopoietic stem cells from a patient, introduces a harmless virus into them that expresses a correct version of the m
'"/>

Source:Whitehead Institute for Biomedical Research


Page: 1 2 3

Related biology news :

1. Powerful new tool for studying brain development
2. Powerful genome ID method extended to humans
3. New lab technique identifies high levels of pathogens in therapy pool
4. Brain-mapping technique aids understanding of sleep, wakefulness
5. Study reveals new technique for fingerprinting environmental samples
6. Researchers pioneer new gene therapy technique using natural repair process
7. Newer imaging techniques may lead to over-treatment
8. Gene silencing technique offers new strategy for treating, curing disease
9. Mosaic mouse technique offers a powerful new tool to study diseases and genetics
10. Researchers devise new technique for creating human stem cells
11. New technique rapidly detects illness-causing bacteria
Post Your Comments:
(Date:12/17/2014)... 2014 Research and Markets ( ... "Samsung Galaxy S5 - Home Button Synaptics ... offering. http://photos.prnewswire.com/prnh/20130307/600769 ... technology than the iPhone 5S, Samsung introduces for ... product. The Galaxy S5 home button ...
(Date:12/17/2014)... , Dec. 16, 2014 Valencell, a leader ... PerformTek biometric technology to industry leaders such as Intel, ... clinically validated, biometric wearable products. These products will be ... Las Vegas . ... accurate, flexible and robust – with the clinical data ...
(Date:12/15/2014)... DUBLIN , Dec. 12, 2014 Research ... announced the addition of the "Global Facial ... http://photos.prnewswire.com/prnh/20130307/600769 ... the identification of individuals. Facial recognition system measures ... as nose, jaw edges, mouth, and the distance ...
Breaking Biology News(10 mins):Samsung Galaxy S5 - Home Button Synaptics Fingerprint Sensor Technology Analysis 2Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3
... , July 8, 2013 /PRNewswire-iReach/ -- Jade Holding Group, LLC ... plastic surgery and wellness centers, has just added a new ... Lipo procedure. In addition, Tickle Lipo has proven to be ... its special pricing for the procedure. (Photo: ...
... hairlike flagella that extend from their unicellular bodies. Some bacteria, ... living in the human gut, have multiple flagella that rotate ... turn somewhat acrobatically by unbundling their flagella, causing the cell ... But many microbes, including 90 percent of motile marine bacteria, ...
... , July 8, 2013  Fluke Biomedical, a global ... today the debut of its new ProSim 3 ... portability, the light and easy to carry ProSim 3 ... maintenance and repairs in the field. ...
Cached Biology News:Strax Rejuvenation Adds New Page to Website Devoted to Tickle Lipo Procedure 2Buckling up to turn 2Buckling up to turn 3Buckling up to turn 4Fluke Biomedical launches portable, feature-rich ProSim 3 and 2 Vital Signs Simulators 2
(Date:12/17/2014)... 17, 2014  United Therapeutics Corporation (NASDAQ: ... well as changes to Martine Rothblatt , Ph.D,s ... United Therapeutics announced the promotion of ... Officer and David Zaccardelli , Pharm.D. to Executive ... these promotions, Dr. Rothblatt,s title will change from Chairman ...
(Date:12/17/2014)... , Dec. 17, 2014 Tigercat Pharma, ... 2 study evaluating the investigational oral NK-1 receptor ... with severe, chronic itch who are unresponsive or ... including topical steroids and antihistamines. ... Visual Analog Scale (VAS) itch score from baseline, ...
(Date:12/15/2014)... 15, 2014 METTLER TOLEDO is ... tool, ParticleView V19 with PVM technology , ... particle vision and measurement tool continuously captures high-resolution ... ParticleView V19 then automatically prepares a report pairing ... size and concentration changes. This compelling blend of ...
(Date:12/15/2014)... Organovo Holdings, Inc. (NYSE MKT: ONVO) ... breakthrough 3D bioprinting technology,  today celebrated continued positive ... exVive3D TM Human Liver Tissue.  The product, ... release on November 18, has been recognized as ... for innovation. Most recently, on December ...
Breaking Biology Technology:United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 3United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 4Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4New Real-Time In Situ Probe-Based Video Microscope from METTLER TOLEDO 2Organovo Celebrates a Positive 2014 Reception of its exVive3DTM Human Liver Tissue Product 2Organovo Celebrates a Positive 2014 Reception of its exVive3DTM Human Liver Tissue Product 3
... in denial, are shunning the subject. Smart ones are coming ... This is a revolution, and the entire model is about ... Explosion , ,The receptacles to receive the conventional TV ... handheld devices or the hundreds of gadgets and screens lying ...
... 2 of a two part interview. Read Part ... experience gives him rare insight into the world of entrepreneurship ... him that to succeed at anything, tenacity is essential. ... from the place Sargeant knew as a child. In June, ...
... Murder Mystery game Madison, Wis. - ... UW-Madison School of Education, hopes to bring a new ... which combine aspects of physical activity, traditional reading and ... the UW System and the Academic ADL Co-Lab ...
Cached Biology Technology:When TV surrenders to Web... 2When TV surrenders to Web... 3Winslow Sargeant: Stepping onto the train called Wisconsin - Part 2 2Winslow Sargeant: Stepping onto the train called Wisconsin - Part 2 3Winslow Sargeant: Stepping onto the train called Wisconsin - Part 2 4Augmented reality brings a new dimension to learning 2Augmented reality brings a new dimension to learning 3
... Imaging Systems offer an optional X-Ray ... researchers to conveniently capture and precisely ... and whole animals with molecular based ... molecular signals that are generated by ...
... vinyl curtains or parting strip ... support frame to form a ... meets cleanliness to Class 10/ISO ... units, lights, and ionizers are ...
... The first high-density serum biomarker chip ... serum proteins. An antibody chip containing 120 ... tool that enables biomarker discovery scientists to ... detection, benefits of therapy and the likelihood ...
... sensitive reagent for the detection of inorganic ... of recombinant E. coli phosphate-binding protein labeled ... to changes in its environment.How it worksBinding ... rapid and tight (Kd ~ 0.1 M), ...
Biology Products: