Navigation Links
Powerful technique for multiplying adult stem cells may aid therapies

Adult stem cells may be free of the ethical concerns that hamper embryonic stem cell research, but they still pose formidable scientific challenges. Chief among these is the doggedness with which adult stem cells differentiate into mature tissue the moment they're isolated from the body. This makes it nearly impossible for researchers to multiply them in the laboratory. And because adult stem cells are so rare, that makes it difficult to use them for treating disease.

Now, researchers in the lab of Whitehead Institute Member and MIT professor of biology Harvey Lodish have discovered a way to multiply an adult stem cell 30-fold, an expansion that offers tremendous promise for treatments such as bone marrow transplants and perhaps even gene therapy.

"A 30-fold increase is ten times higher than anyone's achieved before," says Lodish, senior author on the paper, which will be published January 22 online in Nature Medicine.

Unlike embryonic stem cells, adult stem cells are generally tissue-specific, each one destined to develop into several kinds of cells. Chengcheng Zhang, a postdoctoral researcher in the Lodish lab, was determined to develop a way to multiply adult stem cells once they've been isolated from tissue. Achieving this goal required some intricate laboratory sleuthing.

Zhang began by studying adult hematopoietic--blood cell forming--stem cells. Offspring of some of these cells develop into all of the red and white blood cells, while others form the immune system. Using fetal tissue from mice as the source of these cells, Zhang discovered a population of cells that were not stem cells, yet appeared to interact with stem cells, preserving and allowing them to multiply in the fetal environment. When he isolated the stem cells in the lab and cultured them in a dish by themselves, they died. When he mixed them with these newly discovered cells, they thrived. But how did these new cells manage to sustain the stem cells so
'"/>

Source:Whitehead Institute for Biomedical Research


Page: 1 2 3

Related biology news :

1. Powerful new tool for studying brain development
2. Powerful genome ID method extended to humans
3. New lab technique identifies high levels of pathogens in therapy pool
4. Brain-mapping technique aids understanding of sleep, wakefulness
5. Study reveals new technique for fingerprinting environmental samples
6. Researchers pioneer new gene therapy technique using natural repair process
7. Newer imaging techniques may lead to over-treatment
8. Gene silencing technique offers new strategy for treating, curing disease
9. Mosaic mouse technique offers a powerful new tool to study diseases and genetics
10. Researchers devise new technique for creating human stem cells
11. New technique rapidly detects illness-causing bacteria
Post Your Comments:
(Date:7/31/2014)... the United States, natural-gas production from shale rock ... 2007. Yet scientists still do not fully understand ... to a report in the journal Frontiers ... gas extraction continues to vastly outpace scientific examination, ... organizations and institutions, including Princeton University, concluded that ...
(Date:7/31/2014)... By tracing nearly 3,000 genes to the earliest ... Florida scientists have created an extensive "Tree of ... next-generation DNA sequencing. , Among the study,s ... to small moths than to large ones, which ... The study also found that some insects once ...
(Date:7/31/2014)... study (HPV-023; NCT00518336) shows the sustained efficacy, ... virus (HPV) vaccine Cervarix. Women vaccinated with ... more than nine years, and vaccine efficacy ... is the longest follow-up report for a ... for the full paper. , HPV ...
Breaking Biology News(10 mins):'Fracking' in the dark: Biological fallout of shale-gas production still largely unknown 2'Fracking' in the dark: Biological fallout of shale-gas production still largely unknown 3UF study advances 'DNA revolution,' tells butterflies' evolutionary history 2UF study advances 'DNA revolution,' tells butterflies' evolutionary history 3Sustained efficacy, immunogenicity, and safety for GlaxoSmithKline's HPV vaccine 2Sustained efficacy, immunogenicity, and safety for GlaxoSmithKline's HPV vaccine 3
... Head and neck cancer is the sixth most common ... demographic groups, including young women without any known risk factors. ... may increase the movement of precancerous cells in the mouth ... oral cavity. The new results, published in the ...
... adult height may be caused by genetic inheritance, but a ... to be discovered. Now a new meta-analysis of ... over two dozen genes that were not previously associated with ... 30 previously known height genes. "Although the discoveries may not ...
... The hair color of an unknown perpetrator who has ... for forensic investigators. Erasmus MC scientists, in collaboration with their ... predict people,s probable hair color. Their findings will be published ... The research findings demonstrate that on the basis of DNA ...
Cached Biology News:Estrogen may help precancerous cells spread in oral cavity 2CHOP-led study detects dozens of genes for adult height 2CHOP-led study detects dozens of genes for adult height 3Hair color of unknown offenders is no longer a secret 2
(Date:7/31/2014)... University Bloomington have described the self-assembly of large, ... potential value for the field of organic electronic ... , Their paper, "Anion-Induced Dimerization of 5-fold Symmetric ... Crystals," has been published online by Chemical ... of Chemistry. It is the first collaboration by ...
(Date:7/31/2014)... Yonkers, NY (PRWEB) July 31, 2014 ... use in high temperature oven carts. These bearings are ... occur in sealed ball bearings because of the ... purity alumina requested help from the design engineers at ... through a heating process. During their manufacturing operation, pans ...
(Date:7/31/2014)... July 31, 2014 CollabRx, Inc. (NASDAQ: ... therapeutic decision-making in oncology, today announced that it will ... to discuss the Company's financial results for the first ... about the business in the current fiscal year. , ... on Thursday, August 14, 2014, at 5 p.m. EDT ...
(Date:7/31/2014)... 31, 2014 Held at the Stanford ... an overview of the disease and its treatment. Survivors ... effects, as well as updates on the state-of-the-art with ... Sandy Srinivas for organizing this educational opportunity,” says KCA ... “Sandy and her colleagues have put together a program ...
Breaking Biology Technology:Chemists demonstrate 'bricks-and-mortar' assembly of new molecular structures 2Chemists demonstrate 'bricks-and-mortar' assembly of new molecular structures 3Graphite Metallizing Announces Bearings for High Temperature Oven Applications 2Graphite Metallizing Announces Bearings for High Temperature Oven Applications 3CollabRx, Inc. Schedules First Quarter Fiscal Year 2015 Financial Conference Call and Business Update 2
... YORK, Sept. 13 Regenicin™, Inc. ... clinical-stage biotechnology company, announced today that John J. Weber, ... Medical Systems, USA, Inc. ("Fujifilm USA"), has agreed to ... of directors and interim Chief Financial Officer.  Weber brings ...
... CLEVELAND, Sept. 13 /PRNewswire/-- DATATRAK International, Inc. (OTCQX: DATA), a ... for the clinical trials industry, announced today that Zacks ... effective September 13, 2010. Zacks is a leading provider ... this research report can be obtained by contacting Mr. ...
... Inc. (OTC Bulletin Board: CSBR ), a company ... specific data to enhance the value of oncology drugs, today ... ended July 31, 2010.  Full details of the Company,s financial ... www.championsbiotechnology.com . Total revenues for the first ...
Cached Biology Technology:Former Fujifilm Medical Systems USA Executive John J. Weber Agrees to Join Regenicin™ as a Member of Its Board of Directors and Interim CFO 2DATATRAK International, Inc. Announces Initial Equity Research Coverage by Zacks Investment Research 2DATATRAK International, Inc. Announces Initial Equity Research Coverage by Zacks Investment Research 3Champions Biotechnology Reports Fiscal 2011 First Quarter Financial Results 2Champions Biotechnology Reports Fiscal 2011 First Quarter Financial Results 3Champions Biotechnology Reports Fiscal 2011 First Quarter Financial Results 4
... is the research-grade spectrofluorometer with a minimum ... S/N ratio 200 or greater for the ... especially designed to keep in mind in ... kinetics, stopped-flow, titration, or anisotropic measurements. ,The ...
... Microarrays designed for genome-wide microRNA expression ... and powerful Paraflo microfluidic on-chip synthesis ... part of our comprehensive microRNA Expression ... The Fishes microRNA Microarray contains ...
... microRNA expression profiling and built on ... on-chip synthesis platform. These microarrays are ... microRNA Expression Profiling Service. ... Microarray contains all known virus microRNAs ...
... The LTQ XL extends the legendary MSn ... to generate structural information through Thermo Scientifics ... Scientific's LTQ XL is the only mass ... ETD and CID. Pulsed Q Collision ...
Biology Products: