Navigation Links
Powerful new tool for studying brain development

in production and transporting molecules within the cell.

A key part of the BGEM's success was the development at St. Jude of bioinformatics software that routinely searches scientific databases for new information on genes linked to brain development, said Perdeep Mehta, Ph.D., the group leader in bioinformatics at St. Jude's Hartwell Center for Bioinformatics and Biotechnology. Bioinformatics is the use of computers, software and other technologies to gather, organize, format and use large amounts of biological information. "Our ability to link images of gene expression patterns to information on those genes in other databases increases the value of each new gene discovery," Mehta said.

This integration of multiple research approaches and information provided by the BGEM was key to the success of a St. Jude study of the origin of human brain tumors in children. The team used a technique called microarray analysis to study gene expression patterns in samples of human brain tumors called ependymomas. By comparing the gene expression patterns in human ependymomas with those in the normal developing mouse nervous system provided by the BGEM, the St. Jude investigators demonstrated that specific brain cells, called radial glial cells, likely gave rise to ependymomas.

"Our demonstration that identical-looking ependymomas that arise in different regions of the central nervous system are distinct diseases because they arise from different stem cells is an important insight," said Richard Gilbertson, M.D., Ph.D., the senior author of a report on this work that appeared in the October 2005 issue of Cancer Cell. "This suggests that treatments should be designed to kill the underlying cancer stem cell population. If you kill only the cells making up the bulk of the tumor, the disease will likely return, because you haven't eliminated the source of the tumor.

Further, our comparative analysis of malignant and normal developing tissues provides
'"/>

Source:St. Jude Children's Research Hospital


Page: 1 2 3 4

Related biology news :

1. Powerful technique for multiplying adult stem cells may aid therapies
2. Powerful genome ID method extended to humans
3. Researchers develop new method for studying mental time travel
4. Disappearing nest egg: Researcher studying declining numbers of macaws
5. Researchers make progress in studying genetic traits of India-born populations
6. Sandia researchers take new approach to studying how cells respond to pathogens
7. Controversial drug shown to act on brain protein to cut alcohol use
8. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
9. Mouse brain tumors mimic those in human genetic disorder
10. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
11. First atlas of key brain genes could speed research on cancer, neurological diseases
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Powerful new tool for studying brain development

(Date:12/10/2014)... , Dec. 08, 2014 Research and ... the addition of the "Biometrics Market in ... http://photos.prnewswire.com/prnh/20130307/600769 ... projects such as rural banking and upgradation of ... trends witnessed in the market. Besides the aforementioned ...
(Date:12/5/2014)... 2014 Increased emphasis on product quality, ... testing and inspection technologies. The convergence of industries ... range of innovative test solutions. This trend is ... which is generally more inclined towards communication, media ... strategies of test equipment vendors will cater to ...
(Date:12/4/2014)... BEACH GARDENS, Fla. , Dec. 3, 2014 ... management solutions, today announced that its DigitalPersona ® ... 4500 fingerprint readers have been deployed throughout First ... , South Carolina ... headquartered in Southern Pines, North Carolina ...
Breaking Biology News(10 mins):Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3
... are developing a cost-effective electronic monitoring system that will ... ecosystems by allowing users to track water-quality data from ... a National Science Foundation (NSF) grant. "Our goal ... environmental conditions in the Chesapeake Bay, the sounds of ...
... to help the government cut through red tape and roll ... This week, the university,s Durham Energy ... meet with the Department of Energy & Climate Change to ... on Wednesday November 3rd will also be attended by Ofgem ...
... Calif., Nov. 1, 2010 General Manifolds LLC, a ... that the United States Patent and Trademark Office has ... method for simulating functions within the cerebral cortex of ... a broad range of applications from artificial intelligence to ...
Cached Biology News:Researchers developing real-time electronic monitoring for coastal waters 2Durham Energy Institute to advise government on green technology 2General Manifolds LLC Announces Issuance of US Patent in Computational Neuroscience 2
(Date:12/19/2014)... 18, 2014 Relmada Therapeutics, Inc. (OTCQB: RLMD), ... of chronic pain, announced the results of its annual ... was a transformational year in Relmada,s history and it ... company," said Sergio Traversa , chief executive officer ... on key financial, human resource and clinical development objectives ...
(Date:12/17/2014)... TX (PRWEB) December 17, 2014 Achim ... and administration for Stoller Group. In this position, Noack ... Group, on administrative matters, develop marketing strategy and supervise ... services. , “Achim has tremendous knowledge and experience ... of Stoller Group. “His experience and innovative thinking will ...
(Date:12/17/2014)... Indianapolis, IN (PRWEB) December 17, 2014 ... for Laboratory Excellence following its most recent COLA ... Accreditation by COLA, a national healthcare accreditation organization. ... rigid standards of quality in day-to-day operations, demonstrate ... and pass a rigorous on-site laboratory survey. ...
(Date:12/17/2014)... 2014  United Therapeutics Corporation (NASDAQ: UTHR ... as changes to Martine Rothblatt , Ph.D,s compensation ... United Therapeutics announced the promotion of Roger ... and David Zaccardelli , Pharm.D. to Executive Vice ... promotions, Dr. Rothblatt,s title will change from Chairman and ...
Breaking Biology Technology:Relmada Therapeutics Announces Results of Annual Shareholders Meeting 2Achim Noack Joins Stoller Group as Global Vice President of Marketing and Administration 2Xeno Diagnostics Receives 3rd Award for Laboratory Excellence 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 2United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 3United Therapeutics Corporation Announces Executive Promotions and CEO Compensation Change 4
... CALUIRE, France, Feb. 19 Setaram,Inc., a ... announces the acquisition of Hy-Energy LLC (Newark, ... scientific instruments for,the ever-expanding field of clean ... a full suite of analytical capabilities which,complement ...
... 19 Barr Pharmaceuticals,Inc. (NYSE: BRL ) ... received final approval from the U.S. Food and ... Ingelheim,Pharmaceuticals, Inc.,s Mirapex(R) Tablets (Pramipexole Dihydrochloride),0.125mg, 0.25mg, 0.5mg, ... is the,first to file an Abbreviated New Drug ...
... Technology Providers Broadens ... Opportunities for Distribution, New Markets, SILVER SPRING ... and Immersion Medical, a subsidiary of Immersion Corporation,announced ... enhanced version of B-Line Medical,s SimCapture(TM) product. SimCapture,is ...
Cached Biology Technology:Setaram Inc. Acquires Hy-Energy LLC 2Barr Receives Final Approval for Generic Mirapex(R) Tablets, 0.125mg, 0.25mg, 0.5mg, 1mg & 1.5mg 2Barr Receives Final Approval for Generic Mirapex(R) Tablets, 0.125mg, 0.25mg, 0.5mg, 1mg & 1.5mg 3Barr Receives Final Approval for Generic Mirapex(R) Tablets, 0.125mg, 0.25mg, 0.5mg, 1mg & 1.5mg 4B-Line Medical and Immersion Medical Announce Partnership 2B-Line Medical and Immersion Medical Announce Partnership 3
... 500 Series is a sophisticated ... most advanced technologies available. The ... testing, powerful software and a ... researchers optimize their overall workflow ...
... of a protein into cells permits studies ... pathways, apoptotic pathways, and transcription factor-mediated gene ... the effects of a specific protein in ... protein directly into the cell. ProteoJuice Protein ...
Reacti-Bind DNA Coating Solution...
Immunogen GST fusion protein corresponding to full-length rat JNK3/ SAPK1b. Quality Assurance Routinely evaluated by immunoblot. Stability 2 years at -20°C from date of shipment GenBank A...
Biology Products: