Navigation Links
Powerful new tool for studying brain development

in production and transporting molecules within the cell.

A key part of the BGEM's success was the development at St. Jude of bioinformatics software that routinely searches scientific databases for new information on genes linked to brain development, said Perdeep Mehta, Ph.D., the group leader in bioinformatics at St. Jude's Hartwell Center for Bioinformatics and Biotechnology. Bioinformatics is the use of computers, software and other technologies to gather, organize, format and use large amounts of biological information. "Our ability to link images of gene expression patterns to information on those genes in other databases increases the value of each new gene discovery," Mehta said.

This integration of multiple research approaches and information provided by the BGEM was key to the success of a St. Jude study of the origin of human brain tumors in children. The team used a technique called microarray analysis to study gene expression patterns in samples of human brain tumors called ependymomas. By comparing the gene expression patterns in human ependymomas with those in the normal developing mouse nervous system provided by the BGEM, the St. Jude investigators demonstrated that specific brain cells, called radial glial cells, likely gave rise to ependymomas.

"Our demonstration that identical-looking ependymomas that arise in different regions of the central nervous system are distinct diseases because they arise from different stem cells is an important insight," said Richard Gilbertson, M.D., Ph.D., the senior author of a report on this work that appeared in the October 2005 issue of Cancer Cell. "This suggests that treatments should be designed to kill the underlying cancer stem cell population. If you kill only the cells making up the bulk of the tumor, the disease will likely return, because you haven't eliminated the source of the tumor.

Further, our comparative analysis of malignant and normal developing tissues provides
'"/>

Source:St. Jude Children's Research Hospital


Page: 1 2 3 4

Related biology news :

1. Powerful technique for multiplying adult stem cells may aid therapies
2. Powerful genome ID method extended to humans
3. Researchers develop new method for studying mental time travel
4. Disappearing nest egg: Researcher studying declining numbers of macaws
5. Researchers make progress in studying genetic traits of India-born populations
6. Sandia researchers take new approach to studying how cells respond to pathogens
7. Controversial drug shown to act on brain protein to cut alcohol use
8. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
9. Mouse brain tumors mimic those in human genetic disorder
10. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
11. First atlas of key brain genes could speed research on cancer, neurological diseases
Post Your Comments:
(Date:12/3/2009)... past three years in the troposphere (lower atmosphere) over ... which are the first of their kind in the ... 2002 and 2005. , Over recent years, physicists and ... dioxide (CO2) levels, and how these have evolved in ...
(Date:12/3/2009)... UPTON, NY A team of scientists from the ... University, and the Indian Institute of Science has made ... genetic information in DNA that is necessary to carry ... December 1, 2009 edition of Nature Structural & ...
(Date:12/2/2009)... to secondhand cigarette smoke have an increased risk of developing ... , Results of this study are published in Cancer ... Association for Cancer Research, as part of a special tobacco ... more than 219,000 Americans will be diagnosed with lung cancer; ...
Breaking Biology News(10 mins):CO2 levels rising in troposphere over rural areas 2Grooving down the helix 2Grooving down the helix 3Secondhand smoke exposure in childhood increases lung cancer risk later in life 2Vanda Pharmaceuticals Enters into an Exclusive License Agreement for the Commercialization and Development of Fanapt 28TM 29 in the U S and Canada fo 5409 1Vanda Pharmaceuticals Enters into an Exclusive License Agreement for the Commercialization and Development of Fanapt 28TM 29 in the U S and Canada fo 5409 2Vanda Pharmaceuticals Enters into an Exclusive License Agreement for the Commercialization and Development of Fanapt 28TM 29 in the U S and Canada fo 5409 3Vanda Pharmaceuticals Enters into an Exclusive License Agreement for the Commercialization and Development of Fanapt 28TM 29 in the U S and Canada fo 5409 4Vanda Pharmaceuticals Enters into an Exclusive License Agreement for the Commercialization and Development of Fanapt 28TM 29 in the U S and Canada fo 5409 5Vanda Pharmaceuticals Enters into an Exclusive License Agreement for the Commercialization and Development of Fanapt 28TM 29 in the U S and Canada fo 5409 6Vanda Pharmaceuticals Enters into an Exclusive License Agreement for the Commercialization and Development of Fanapt 28TM 29 in the U S and Canada fo 5409 7Vanda Pharmaceuticals Enters into an Exclusive License Agreement for the Commercialization and Development of Fanapt 28TM 29 in the U S and Canada fo 5409 8New Editor Named for International Journal Of Nursing Terminologies 26amp 3B Classifications 59323 1New Editor Named for International Journal Of Nursing Terminologies 26amp 3B Classifications 59323 2Capital BlueCross Reaches Out to Former Employees of Turbine Airfoil Designs 59319 1Capital BlueCross Reaches Out to Former Employees of Turbine Airfoil Designs 59319 2
... first time the ability to create 3-D positron ... and "fly-around viewing" of cancer in the lungs ... July issue of the Journal of Nuclear Medicine. ... with accurate anatomical information of possible cancerous tumors--from ...
... of people while they walk, researchers have improved our understanding ... at the same time, the researchers found that the stimulus ... who was walking straight ahead to be steered by "remote ... by Richard Fitzpatrick and Jane E. Butler of the Prince ...
... (UC) researchers say exposure to a certain group of ... day--can make young children more susceptible to developing multiple ... that infants who were exposed to basidiospores and other ... more likely to develop allergies to mold, pollen, dust ...
Other Biology News:Coming soon: 3-D imaging that flies 'through' and 'around' cancer 2Coming soon: 3-D imaging that flies 'through' and 'around' cancer 3Stimulation of the semicircular canals can artificially control human walking and balance 2Airborne mold spores increase kids' risk for multiple allergies 2
(Date:12/3/2009)... HOUSTON, Dec. 3 JourneyLite of Houston, LLC ... to offer patients a second surgical option, vertical ... that it currently performs. The first sleeve gastrectomy ... Matthew St. Laurent, MD on October 20, ...
(Date:12/3/2009)... Shire plc (LSE: SHP, Nasdaq: SHPGY ), the ... of five lots and voluntary market withdrawal of one ... . Shire is taking this action because some Daytrana ... not meet their release liner removal specification, and as ...
(Date:12/3/2009)... Dr. Susan Jiang, M.D., Ph.D.,Chief Science Officer at ... spoke at a conference on High-Risk Diabetic,Foot Care ... is China,s leading,stem cell research and regenerative medicine ... organized by the Indian Podiatry Association (IPA), aimed,to ...
(Date:12/2/2009)... NEW YORK, Dec. 2 Reportlinker.com announces ... available in its catalogue: ,, Carbondioxide ... ,, http://www.reportlinker.com/p0164368/Carbondioxide-Incubators---A-Global-Market-Perspective.html ,, Incubators ... microbiology, genetics, cancer, research, and other applications ...
Breaking Biology Technology:JourneyLite of Houston Now Offering Sleeve Gastrectomy 2Non-safety-related voluntary recall of a limited portion of Daytrana(R) (methylphenidate transdermal system) patches announced 2Non-safety-related voluntary recall of a limited portion of Daytrana(R) (methylphenidate transdermal system) patches announced 3Non-safety-related voluntary recall of a limited portion of Daytrana(R) (methylphenidate transdermal system) patches announced 4Non-safety-related voluntary recall of a limited portion of Daytrana(R) (methylphenidate transdermal system) patches announced 5Beike Biotechnology CSO Speaks on Role of Stem Cells in Treating Diabetic Foot Disease at IPA Diabetic Foot Care Conference, India 2Beike Biotechnology CSO Speaks on Role of Stem Cells in Treating Diabetic Foot Disease at IPA Diabetic Foot Care Conference, India 3Reportlinker Adds Carbondioxide Incubators - A Global Market Perspective 2Reportlinker Adds Carbondioxide Incubators - A Global Market Perspective 3Reportlinker Adds Carbondioxide Incubators - A Global Market Perspective 4
... ) announced today that an Australia/New Zealand-focused clinical evaluation of its ... in a self-expanding frame, was initiated last week. , ... ... The first four procedures using the CoreValve ReValving System were ...
... TITUSVILLE, N.J., Aug. 28 Ortho-McNeil Neurologics,Division ... appeal yesterday,s decision by the U.S. District ... RAZADYNE(R) (galantamine hydrobromide) is,invalid., The decision ... to enter the U.S. marketplace "at risk" ...
... inspired by historic,Philadelphia, Pa. and revel in the ... room rate while you discover best practices and ... Hewlett-Packard,Johnson & Johnson, Motorola, Nortel, Roche, Sanofi-Aventis and ... Excellence Conference: How Process,Improvement Leaders Produce Profits in ...
Other Biology Technology: CoreValve Successfully Treats the First Pacific Rim Patients with Its ReValving System for Percutaneous Aortic Valve Replacement : Australia/New Zealand Regulatory-Cleared Evaluation Registry is Expected to Lead to Market Clearance for These Countries 2Ortho-McNeil Neurologics to Appeal Patent Ruling on RAZADYNE(R) 2Ortho-McNeil Neurologics to Appeal Patent Ruling on RAZADYNE(R) 3Early-Bird Registration Ends this Week for 10th Annual Quality Excellence Conference: How Process Improvement Leaders Produce Profits in Recessions 2
... Tracker is an automated solution for scheduling, ... performance testing for all pipettes and liquid ... any balance Supports all gravimetric ... DIN 12650, ISO 9000, NCCLS and GLP ...
... plasmid DNA preparations are prepared from ... from 1mg to multi-gram scales. ... (100mg-multi-gram) preparations are made according to ... formulated according to customer needs, and ...
... are polypeptide hormones which belong to ... The TGF- superfamily is a large ... control many aspects of development, reproductive ... members incude TGF-s, bone morphogenetic proteins, ...
... systems need to be able to handle larger ... ports, as well as interface with telemetry systems. ... more, particularly with dogs, pigs, and primates. ... starting time, and the computer can be located ...
Biology Products: