Navigation Links
Powerful new tool for studying brain development

in production and transporting molecules within the cell.

A key part of the BGEM's success was the development at St. Jude of bioinformatics software that routinely searches scientific databases for new information on genes linked to brain development, said Perdeep Mehta, Ph.D., the group leader in bioinformatics at St. Jude's Hartwell Center for Bioinformatics and Biotechnology. Bioinformatics is the use of computers, software and other technologies to gather, organize, format and use large amounts of biological information. "Our ability to link images of gene expression patterns to information on those genes in other databases increases the value of each new gene discovery," Mehta said.

This integration of multiple research approaches and information provided by the BGEM was key to the success of a St. Jude study of the origin of human brain tumors in children. The team used a technique called microarray analysis to study gene expression patterns in samples of human brain tumors called ependymomas. By comparing the gene expression patterns in human ependymomas with those in the normal developing mouse nervous system provided by the BGEM, the St. Jude investigators demonstrated that specific brain cells, called radial glial cells, likely gave rise to ependymomas.

"Our demonstration that identical-looking ependymomas that arise in different regions of the central nervous system are distinct diseases because they arise from different stem cells is an important insight," said Richard Gilbertson, M.D., Ph.D., the senior author of a report on this work that appeared in the October 2005 issue of Cancer Cell. "This suggests that treatments should be designed to kill the underlying cancer stem cell population. If you kill only the cells making up the bulk of the tumor, the disease will likely return, because you haven't eliminated the source of the tumor.

Further, our comparative analysis of malignant and normal developing tissues provides
'"/>

Source:St. Jude Children's Research Hospital


Page: 1 2 3 4

Related biology news :

1. Powerful technique for multiplying adult stem cells may aid therapies
2. Powerful genome ID method extended to humans
3. Researchers develop new method for studying mental time travel
4. Disappearing nest egg: Researcher studying declining numbers of macaws
5. Researchers make progress in studying genetic traits of India-born populations
6. Sandia researchers take new approach to studying how cells respond to pathogens
7. Controversial drug shown to act on brain protein to cut alcohol use
8. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
9. Mouse brain tumors mimic those in human genetic disorder
10. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
11. First atlas of key brain genes could speed research on cancer, neurological diseases
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Powerful new tool for studying brain development

(Date:3/20/2015)... and Markets ( http://www.researchandmarkets.com/research/vkzvcs/iris_biometrics ) has announced the ... Report" report to their offering. This report ... The report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... . Annual estimates and forecasts are provided ...
(Date:3/18/2015)... SPRINGS, Florida , March 18, 2015 ... well as businesses, new revolutionary smart wallets and apps continue ... pace.  Companies currently entrenched in the mobile payment industry in ... Alibaba Group Holding Ltd. (NYSE: BABA ), Apple ... GOOG ) and Facebook Inc. (NASDAQ: FB ...
(Date:3/17/2015)... , March 17, 2015 Emotient, ... analytics software, today announced general availability of ... service for the analysis of facial expressions. The ... advertising, media content, products and services. It delivers ... engagement and sentiment - as derived from facial ...
Breaking Biology News(10 mins):Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 2Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 5Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 2Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 3Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 4Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 5Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 6New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 2New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 3New Emotient Web Service Measures Audience Response Using On-Demand Facial Expression Analysis 4
... your average persons idea of a good time, but for ... I think worms are totally cool, like humans only simpler ... working with the invertebrates is what will bring Dr. Fraser ... he will present some of his research findings in a ...
... ALBUQUERQUE, N.M. As Americans demand new and cleaner ... turning to algae as a promising new fuel source. ... nation,s reliance on imported oil while contributing to rural ... that algae-based biofuels could displace large volumes of diesel ...
... The American Association for Dental Research (AADR) has announced ... Chilton Fellowship in Clinical Research recipient. He will be ... Washington, DC, March 3, 2010. Currently, Dawson is ... the Delta Dental of Kentucky Clinical Research Center, in ...
Cached Biology News:The impact of genomics 2Fueling the future with fish tank residue: Sandia scientist discusses use of algae as a biofuel 2Fueling the future with fish tank residue: Sandia scientist discusses use of algae as a biofuel 3Fueling the future with fish tank residue: Sandia scientist discusses use of algae as a biofuel 4
(Date:4/21/2015)... Limited (ASX:NRT; NASDAQ: NVGN ) ("Company" or "Novogen"), ... entered into definitive agreements today to issue approximately ... 6-month option and half of one attaching 5-year ... investors in the United States ... proceeds of approximately AU$15,500,000 ("Placement"). The closing of ...
(Date:4/21/2015)... April 21, 2015 Progyny, Inc., the ... LLC, announced that it has secured additional capital from ... Biotech, SR One and Merck Serono Ventures. The funding ... patients the best fertility outcomes by aligning science, technology, ... online marketplace for families seeking fertility solutions and we ...
(Date:4/21/2015)... 21, 2015 Whether it’s used for troubleshooting ... bolted to a Kessler CineDrive in a cinematic ... beach, the TS3-H is designed to help any shooter create ... state-of-the-art 5MP sensor, the TS5-H offers the same convenient touchscreen ... characteristics. , According to Tom Boldt for Fastec, “We ...
(Date:4/20/2015)... and MENLO PARK, Calif. ... Pharmaceuticals, Inc. (OTCQX: DMPI) (DelMar and the ... commercializing proven cancer therapies in new orphan drug ... 106th Annual Meeting of the American Association ... the potential for its lead product candidate ...
Breaking Biology Technology:Novogen Conducts Private Placement and Announces Rights Offering to Shareholders 2Novogen Conducts Private Placement and Announces Rights Offering to Shareholders 3Novogen Conducts Private Placement and Announces Rights Offering to Shareholders 4Novogen Conducts Private Placement and Announces Rights Offering to Shareholders 5Novogen Conducts Private Placement and Announces Rights Offering to Shareholders 6Announcing Progyny: Combining Best-in-Class Clinical Solutions with Consumer Expertise 2Fastec Imaging Releases the TS5-H High Definition High-Speed Camera 2Fastec Imaging Releases the TS5-H High Definition High-Speed Camera 3DelMar Pharmaceuticals Presents Promising Preclinical Data on VAL-083's Potential to Treat Temozolomide-Resistant Glioblastoma Multiforme (GBM) 2DelMar Pharmaceuticals Presents Promising Preclinical Data on VAL-083's Potential to Treat Temozolomide-Resistant Glioblastoma Multiforme (GBM) 3DelMar Pharmaceuticals Presents Promising Preclinical Data on VAL-083's Potential to Treat Temozolomide-Resistant Glioblastoma Multiforme (GBM) 4DelMar Pharmaceuticals Presents Promising Preclinical Data on VAL-083's Potential to Treat Temozolomide-Resistant Glioblastoma Multiforme (GBM) 5
... processing revenues in the third, quarter of 2007 increased 25 percent ... ... Oct. 11 CryoLife, Inc. (NYSE: CRY ),a biomaterials, medical ... revenues for the third quarter,of 2007 were approximately $21.9 million compared ...
... Challenges and Opportunities to Realize ... Critical Path Initiative Goals, ... PHST), a leading provider of software,strategic consulting, and regulatory services ... senior vice,president and chief technology officer, has been invited to ...
... Solstice Neurosciences, Inc.,("Solstice") announced the appointment of ... Smith will serve as Executive Chairman replacing James,Thomas, ... Chairman since Solstice,was founded in July 2004. ... expertise to Solstice that will be invaluable in ...
Cached Biology Technology:CryoLife Announces Preliminary Third Quarter 2007 Revenues of Approximately $21.9 Million 2CryoLife Announces Preliminary Third Quarter 2007 Revenues of Approximately $21.9 Million 3CryoLife Announces Preliminary Third Quarter 2007 Revenues of Approximately $21.9 Million 4CryoLife Announces Preliminary Third Quarter 2007 Revenues of Approximately $21.9 Million 5Pharsight Invited to Present on Winning Strategies for R&D Productivity at New York Pharma Forum on October 15, 2007 2Pharsight Invited to Present on Winning Strategies for R&D Productivity at New York Pharma Forum on October 15, 2007 3Dennis L. Smith Appointed Executive Chairman to Board of Directors of Solstice Neurosciences, Inc. 2
Preparation TW--Compatibility: no end cap seals -Hybridization Tube for Hybrigene -Comp Dim: 240 80 mm -Material: borosilicate glass -Mfr Desig: Techne FHB-15...
...
... For use in hybridization incubators ... and GL 45 size PP plug-seal ... seal. Available in three lengths to ... plug-seal caps and O-rings available separately. ...
... gels The SpinPrep Gel DNA Kit enables efficient ... 12,000 bp in size from agarose gels. The procedure ... by adsorption of the DNA to a silica membrane ... the purified DNA is eluted in low-salt buffer. Each ...
Biology Products: