Navigation Links
Powerful genome ID method extended to humans

A mathematical discovery has extended the reach of a novel genome mapping method to humans, potentially giving cancer biology a faster and more cost-effective tool than traditional DNA sequencing.

A student-led group from the laboratory of Michael Waterman, USC University Professor in molecular and computational biology, has developed an algorithm to handle the massive amounts of data created by a restriction mapping technology known as "optical mapping." Restriction maps provide coordinates on chromosomes analogous to mile markers on freeways.

Lead author Anton Valouev, a recent graduate of Waterman's lab and now a postdoctoral fellow at Stanford University, said the algorithm makes it possible to optically map the human genome.

"It carries tremendous benefits for medical applications, specifically for finding genomic abnormalities," he said.

The algorithm appears in this week's PNAS Early Edition.

Optical mapping was developed at New York University in the late 1990s by David Schwartz, now a professor of chemistry and genetics at the University of Wisconsin-Madison. Schwartz and a collaborator at Wisconsin, Shiguo Zhou, co-authored the PNAS paper.

The power of optical mapping lies in its ability to reveal the size and large-scale structure of a genome. The method uses fluorescence microscopy to image individual DNA molecules that have been divided into orderly fragments by so-called restriction enzymes.

By imaging large numbers of an organism's DNA molecules, optical mapping can produce a map of its genome at a relatively low cost.

An optical map lacks the minute detail of a genetic sequence, but it makes up for that shortcoming in other ways, said Philip Green, a professor of genome sciences at the University of Washington who edited the PNAS paper.

Geneticists often say that humans have 99.9 percent of their DNA in common. But, Green said, "individuals occasionally have big di
'"/>

Source:University of Southern California


Page: 1 2

Related biology news :

1. Powerful new tool for studying brain development
2. Powerful technique for multiplying adult stem cells may aid therapies
3. Man and mouse share genome structures
4. Whole genome fine map of rice completed
5. Study finds more than one-third of human genome regulated by RNA
6. A bacterial genome reveals new targets to combat infectious disease
7. Scientists decipher genome of fungus that can cause life-threatening infections
8. Highly adaptable genome in gut bacterium key to intestinal health
9. Fleshing out the genome
10. Agilent Technologies new genome analysis technology set to accelerate Australia fight against mesothelioma
11. wFleaBase: the Daphnia genome database
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Powerful genome method extended humans

(Date:5/18/2013)... FL (May 18, 2013) An increasing number ... require interventions to resolve, according to research presented ... one study targeting obesity, researchers at the Cleveland ... a unique pattern of exhaled breath compared to ... volatile organic compound levels that can be correlated ...
(Date:5/17/2013)... 18, 2013) The AGA Research Foundation announced a ... relationship between the gut microbiota, one of today,s most ... , The AGA Research Awards Panel selected Andrew ... General Hospital and Harvard Medical School, Boston, as the ... Chan will receive $25,000 of funding, commencing in July ...
(Date:5/17/2013)... white noise of the South, but the night belongs to ... hangs heavy from the humidity and the sounds of wildlife. ... of frogs, toads and salamanders, is the center of amphibian ... are the auditorium for their symphonic choruses, the scientists of ... ARMI, have front-row seats. , Amphibians, which rely ...
Breaking Biology News(10 mins):New research identifies risks, interventions for children's GI health 2New research identifies risks, interventions for children's GI health 3New gut microbiome research to explore red meat -- colorectal cancer pathway 2Front-row seats to climate change 2Front-row seats to climate change 3Front-row seats to climate change 4
... Commercial flower and plant growers know all too ... the value and deterring healthy growth of potted ornamental ... to the expensive practice of paying workers to hand-weed ... is questionable on the wide range of plant species ...
... Tactile Sensors at Your Fingertips, Literally, ... Systems, Inc.,(PPS) today announces their innovative new ... immediate sale worldwide. FingerTPS,sensors are soft, flexible ... accurate,repeatable tactile force data to a PC ...
... reports from TRAFFIC, the world,s largest wildlife trade ... and Vietnam suggest that illegal wildlife trade, including ... the region,s rich and varied biodiversity and putting ... The results of field studies carried ...
Cached Biology News:Ethanol byproduct produces green results 2Wearable Sensors Conceived at Harvard Robotics Lab Measure Hand Forces 2A bitter pill to swallow 2
(Date:5/16/2013)... , May 16, 2013 Scientists at the ... Beijing , and the California ... demonstrated a novel therapy for reversing memory decline in ... they find significant cognitive improvement in advanced stage AD ... mechanism for reversing cognitive decline for advanced stage AD ...
(Date:5/16/2013)... , May 16, 2013 /PRNewswire/ ... market research report is available in ... Competitor Analysis: Therapeutic Proteins ... http://www.reportlinker.com/p01171947/Competitor-Analysis-Therapeutic-Proteins-–-Biosimilars-Biobetters--Biosuperiors.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Biopharmaceutical   ...   The new Competitive ...
(Date:5/16/2013)... May 16, 2013 DNA Genotek, a leading ... for Africa’, a sponsorship program in conjunction with the African ... to improve access and reduce the cost of DNA ... as the Human Heredity and Health in Africa (H3 Africa) ... , The aim of the AfSHG is to ...
(Date:5/16/2013)... New York, NY (PRWEB) May 16, 2013 ... PRMA Insights: Market Access Success for Companion Diagnostic–Drug ... the key issues that biopharmaceutical manufacturers should understand ... medicine is gaining traction, particularly in oncology, with ... NSCLC and Zelboraf for BRAF-mutation positive melanoma. Payors ...
Breaking Biology Technology:Elevation of Brain Magnesium Reverses Memory Deficits in Alzheimer Mice 2Elevation of Brain Magnesium Reverses Memory Deficits in Alzheimer Mice 3Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 2Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 3Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 4Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 5Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 6Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 7Competitor Analysis: Therapeutic Proteins - Biosimilars, Biobetters & Biosuperiors 8DNA Genotek Inc. Announces Spit for Africa Program 2DNA Genotek Inc. Announces Spit for Africa Program 3Market Access Expert Firm, PRMA Consulting, Launches Companion Diagnostics Handbook 2
... from around the world came together today to share their ... (CVBD) forum in Nice, France and call for greater awareness ... increasingly important diseases. "A number of the ... many CVBDs represent a zoonotic risk. It,s vital that veterinarians ...
... of our electronic age rests on our ability to ... point B, through circuitry. Doing so requires particular precision, ... cells, and that task falls to semiconductors. Now, ... of Engineering and Applied Science and Arts and Sciences ...
... at the Hilton San Francisco Union Square, Pam Marrone ... (MBI), will address Agriculture 2.0 conference attendees as ... a Growing Global Population,. The discussion will explore technologies with ... to feed a projected world population of 9 billion people ...
Cached Biology Technology:Veterinarians and Pet Owners Urged to Act Upon Evolving Dangers Posed by CVBDs as New Research Underlines Threats to Animals and Humans 2Veterinarians and Pet Owners Urged to Act Upon Evolving Dangers Posed by CVBDs as New Research Underlines Threats to Animals and Humans 3Veterinarians and Pet Owners Urged to Act Upon Evolving Dangers Posed by CVBDs as New Research Underlines Threats to Animals and Humans 4Penn research advances understanding of lead selenide nanowires 2Penn research advances understanding of lead selenide nanowires 3Pam Marrone to Speak at Ag 2.0 Conference 2
... useful for routine procedures. Hollandes contains formaldehyde ... will decalcify small bone specimens. Tissue that ... successfully with most stains, and the cupric ... cell membranes and cosinophil and endocrine cell ...
... In Vitro Osteogenesis Assay Kit contains all ... a mature osteoblastic lineage, as determined by ... provides all the necessary reagents and a ... plate reader. This product is useful for ...
... standard for automated bioresearch: Developed for ... • Based on decades of experience ... designed for bioresearch • Holographic gratings ... reliability and ease-of-use • Pulsed Xenon ...
... MSn data, the patent-pending Formula Predictor ... of fragmentation, isotope pattern verification, and ... determine the correct formula for unknown ... deducing empirical formulae from mass spec ...
Biology Products: