Navigation Links
Powerful genome ID method extended to humans

A mathematical discovery has extended the reach of a novel genome mapping method to humans, potentially giving cancer biology a faster and more cost-effective tool than traditional DNA sequencing.

A student-led group from the laboratory of Michael Waterman, USC University Professor in molecular and computational biology, has developed an algorithm to handle the massive amounts of data created by a restriction mapping technology known as "optical mapping." Restriction maps provide coordinates on chromosomes analogous to mile markers on freeways.

Lead author Anton Valouev, a recent graduate of Waterman's lab and now a postdoctoral fellow at Stanford University, said the algorithm makes it possible to optically map the human genome.

"It carries tremendous benefits for medical applications, specifically for finding genomic abnormalities," he said.

The algorithm appears in this week's PNAS Early Edition.

Optical mapping was developed at New York University in the late 1990s by David Schwartz, now a professor of chemistry and genetics at the University of Wisconsin-Madison. Schwartz and a collaborator at Wisconsin, Shiguo Zhou, co-authored the PNAS paper.

The power of optical mapping lies in its ability to reveal the size and large-scale structure of a genome. The method uses fluorescence microscopy to image individual DNA molecules that have been divided into orderly fragments by so-called restriction enzymes.

By imaging large numbers of an organism's DNA molecules, optical mapping can produce a map of its genome at a relatively low cost.

An optical map lacks the minute detail of a genetic sequence, but it makes up for that shortcoming in other ways, said Philip Green, a professor of genome sciences at the University of Washington who edited the PNAS paper.

Geneticists often say that humans have 99.9 percent of their DNA in common. But, Green said, "individuals occasionally have big di
'"/>

Source:University of Southern California


Page: 1 2

Related biology news :

1. Powerful new tool for studying brain development
2. Powerful technique for multiplying adult stem cells may aid therapies
3. Man and mouse share genome structures
4. Whole genome fine map of rice completed
5. Study finds more than one-third of human genome regulated by RNA
6. A bacterial genome reveals new targets to combat infectious disease
7. Scientists decipher genome of fungus that can cause life-threatening infections
8. Highly adaptable genome in gut bacterium key to intestinal health
9. Fleshing out the genome
10. Agilent Technologies new genome analysis technology set to accelerate Australia fight against mesothelioma
11. wFleaBase: the Daphnia genome database
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Powerful genome method extended humans

(Date:8/18/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/9dmm6l/global_biometric ... "Global Biometric Authentication & Identification Market: Focus On ... 2015-2020" report to their offering. ... market is expected to grow at an estimated ... generate over $25 billion (approximately) by 2020 as ...
(Date:8/12/2015)... , August 12, 2015 As ... mobile payment innovation and advanced biometrics technology is accelerating ... way consumers rely on using their credit cards, the ... the future for payment services led by companies in ... ), :  Google, Inc. (NASDAQ: GOOG ), Apple ...
(Date:8/11/2015)... GOTHENBURG, Sweden , August 11, 2015 ... sensor FPC1155. Already received as well as expected revenues in 2015 ... included in FPC,s communicated revenue guidance of approximately 2,200 MSEK for ... is a prominent smartphone manufacturer ... ZUK selected FPC1 155 ...
Breaking Biology News(10 mins):Global Biometric Authentication & Identification Market 2015: Focus On Modality, Motility & Application - Estimation & Forecasts to 2020 for the $25 Billion Industry 2Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 2Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 4Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 5Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 6FPC's Touch Fingerprint Sensor FPC1155 in ZUK's Smartphone Z1 2
... may not be enough to experience significant health benefits, ... activity such as walking alone is not likely going ... that occasionally elevate the intensity," said Dr. Vicki Harber, ... presented recently at the American College of Sports Medicine ...
... sepsis, a fast-moving blood infection that is a leading ... illness unleashes a powerful inflammatory response that can quickly ... within days. , With a narrow window of opportunity ... typically rush to prescribe powerful antibiotics, even before laboratory ...
... complete with her brood of some 20 eggs and 2 ... part anatomy including legs and eyes. , The research team ... Siveter from Oxford, Mark Sutton from Imperial College London and ... made a digital image of the fossil - an ostracod ...
Cached Biology News:Walking not enough for significant exercise benefits 2Gene chip technology shows potential for identifying life-threatening blood infection 2Gene chip technology shows potential for identifying life-threatening blood infection 3Gene chip technology shows potential for identifying life-threatening blood infection 4
(Date:9/2/2015)... , Sept. 2, 2015  Neurotech Pharmaceuticals, ... enrolled in the multicenter Phase 2 clinical trial ... long-term treatment of recurrent subfoveal choroidal neovascularization secondary ... is a unique vascular endothelial growth factor (VEGF) ... implant. "This landmark proof-of-concept study will ...
(Date:9/2/2015)... 2015 BioLight Life Sciences ... "Company"), a firm that invests in, manages and ... announced today that presentations highlighting its IOPtiMate™ system ... at the Ophthalmology Futures European Forum and the ... & Refractive Surgeons ("ESCRS"), both taking place in ...
(Date:9/2/2015)... ... September 02, 2015 , ... Whitehouse Laboratories is ... attending Pharma Ed Resources upcoming educational seminar and training session on Extractable & ... timely conference will provide Updates & Case Studies on the Latest Compliance Implications ...
(Date:9/1/2015)... , September 2, 2015 ... auf die Forschung und Entwicklung neuartiger Therapien ... chronisch-entzündliche Darmerkrankungen und Reizdarm konzentriert, erhält vom ... dass sein neues Medikament patentiert wird. Das ... Allergien bei Kindern verhindert und Entzündungen vorbeugt.   ...
Breaking Biology Technology:Neurotech Announces First Patient Enrolled in Novel Anti-VEGF Encapsulated Cell Therapy Study 2Neurotech Announces First Patient Enrolled in Novel Anti-VEGF Encapsulated Cell Therapy Study 3Neurotech Announces First Patient Enrolled in Novel Anti-VEGF Encapsulated Cell Therapy Study 4Presentations to Highlight BioLight's IOPtiMate[TM] System at Upcoming European Ophthalmology Conferences 2Presentations to Highlight BioLight's IOPtiMate[TM] System at Upcoming European Ophthalmology Conferences 3Whitehouse Laboratories to Participate in Pharm Ed Resources Extractables, Leachables, & Elemental Impurities Educational Seminar 2Whitehouse Laboratories to Participate in Pharm Ed Resources Extractables, Leachables, & Elemental Impurities Educational Seminar 3Das Patent von Swecure zur Verhinderung von Allergien bei Kindern wird in den USA zugelassen 2
... EMERYVILLE, Calif., Nov. 4 Onyx Pharmaceuticals, Inc. (Nasdaq: ... at the Credit Suisse 18th Annual Healthcare Conference on ... a.m. Pacific Time). Interested parties may access a ... http://www.onyx-pharm.com/view.cfm/32/Event-Calendar , It is recommended ...
... BOZEN, Italy, November 4 Health Robotics ... i.v.SOFT Workflow Engine at,the American Society of Health-System Pharmacists, ... of the i.v.SOFT Workflow Engine,Health Robotics becomes the first ... automation solution to fill the void of automated process ...
... 4 ThromboGenics NV,(Euronext Brussels: THR), a biopharmaceutical company focused ... today issuing a,business update for the period ending 30 September, ... of ThromboGenics, said: , "ThromboGenics, clinical ... happy to have completed patient enrolment,for the US Phase III ...
Cached Biology Technology:Health Robotics Announces December Launch of the i.v.SOFT(TM) Workflow Engine at ASHP in Las Vegas 2Health Robotics Announces December Launch of the i.v.SOFT(TM) Workflow Engine at ASHP in Las Vegas 3ThromboGenics NV - Q3 2009 Business Update 2ThromboGenics NV - Q3 2009 Business Update 3ThromboGenics NV - Q3 2009 Business Update 4ThromboGenics NV - Q3 2009 Business Update 5ThromboGenics NV - Q3 2009 Business Update 6ThromboGenics NV - Q3 2009 Business Update 7
ANTI S. ENTERID LPS...
B.D. Hames and D.M. Glover (1996) • This issue covers T-Cell antigen receptor genes; T-Lymphocyte signal transduction; B-Cell activation antibody engineering and the complement system and other ...
Request Info...
RABBIT ANTI PORCINE CARBOXYPEPTIDASE B...
Biology Products: