Navigation Links
Power-boosting signal in muscle declines with age

ted to chronic activation of the AMPK pathway.

"In regards to insulin resistance and type 2 diabetes, having more AMPK activity in our skeletal muscle is probably a good thing because AMPK activation stimulates glucose uptake, increases fat oxidation, and promotes mitochondrial biogenesis," he said.

In the current study, the researchers set out to determine whether the declining mitochondrial function and increased intracellular fat content seen with aging could be traced back to deficiencies of AMPK. They compared AMPK activity in young and old rats following three "perturbations" that normally stimulate the enzyme and, in turn, mitochondria production. The treatments included acute exposure to an AMPK-stimulating chemical, chronic exposure through feeding of another chemical that induces AMPK by mimicking an energy shortage, and exercise.

In every case, older rats showed a decline in AMPK activity compared to younger animals. Young rats infused with a stimulatory chemical showed an increase in muscular AMPK activity not seen in old rats, they found. Similarly, the muscle of exercise-trained young rats showed more than a doubling in AMPK activity. In older rats, that AMPK hike with exercise was "severely blunted." The muscles of young rats fed the AMPK-stimulating chemical also showed an increase in AMPK and a 38% increase in mitochondrial density, they reported. In contrast, older animals' AMPK activity and mitochondrial numbers held steady.

"These results suggest that aging-associated reductions in AMPK-stimulated activity may be an important contributing factor in the reduced mitochondrial function and dysregulated intracellular fat metabolism associated with aging-induced insulin resistance and type 2 diabetes," the researchers concluded.
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Plants respond similarly to signals from friends, enemies
2. Bound for destruction: Ubiquitination protects against improper Notch signaling
3. Viral protein influences key cell-signaling pathway
4. Researchers find promising cancer-fighting power of synthetic cell-signaling molecule
5. Edible bivalves as a source of human pathogens: signals between vibrios and the bivalve host.
6. Scientists discover that three overlapping signals in embryo help get the backbone right
7. After a time-shift, mixed signals from the circadian clock
8. Researchers make surprise discovery that some neurons can transmit three signals at once
9. Structure-building cell signals also may influence learning and memory
10. Fox Chase study shows that weakened T-cell receptor signals change T-cell lineage
11. Immune systems distress signal tells bacteria when to strike back
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Power boosting signal muscle declines with age

(Date:12/15/2014)... Dec. 12, 2014 Research and Markets ... of the "Global Facial Recognition Market 2015-2019" ... http://photos.prnewswire.com/prnh/20130307/600769 Facial recognition ... individuals. Facial recognition system measures the overall facial ... edges, mouth, and the distance between eyes. Facial ...
(Date:12/11/2014)... Research and Markets , ... http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the addition of the ... to their offering. One major ... of multimodal biometric systems. Multimodal biometric systems utilize ... verification and identification purposes. This helps to reduce ...
(Date:12/11/2014)... Minn. , Dec. 10, 2014  Data ... physiologic monitoring, has released a new series of ... of preclinical toxicology researchers. M series, part of ... toxicologists collect the best possible physiologic data when ... Adding functional endpoints to toxicology studies has ...
Breaking Biology News(10 mins):Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2New telemetry implants expected to change how large animal toxicology studies are conducted 2
... with seasonal affective disorder (SAD), starting treatment with an ... of developing depression throughout the fall and winter months, ... Biological Psychiatry, official journal of the Society of Biological ... publisher. , "These are the first systematic studies that ...
... presented at the American College of Neuropsychopharmacology's (ACNP) Annual ... necessary for the development of connections between the brain ... Stanford University through a grant from the National Institutes ... of the development of the human brain and possibly ...
... randomized clinical trials have determined that milk thistle ... have any significant influence on the course of ... or C liver disease. These findings are ... According to the previous studies, milk thistle extracts ...
Cached Biology News:In SAD patients, autumn antidepressants can prevent winter depression 2New study identifies key gene in development of connections between brain and spinal cord 2
(Date:12/24/2014)... AUSTIN, Texas , Dec. 23, 2014 /PRNewswire/ ... solutions company focused on gynecologic disease, announced today ... W. Schuler , Birchview Fund LLC and several ... million of unregistered shares of Vermillion,s common stock ... common stock in a private placement.  ...
(Date:12/24/2014)... NEW YORK , Dec. 23, 2014 /PRNewswire/ ... study of mazindol in children with attention deficit/hyperactivity disorder ... December 2014 . The paper, titled ... attention deficit/hyperactivity disorder" ( Konofal et al, ... eCollection 2014 ) shows that mazindol might be ...
(Date:12/22/2014)... CHAPEL HILL, N.C. , Dec. 22, 2014 ... ALNE) today announced that it has signed a ... biotechnology company that has developed and patented a ... and medical diagnostics products that enable rapid on-site ... and alcohol use/abuse and health issues in an ...
(Date:12/22/2014)... ITRA Global, one of the largest ... real estate, has further expanded its global reach with ... Brisbane, Western Australia, reports Mylinda Vick, CCIM, Chairman of ... Global / ACORPP (Australian Corporate Property and Projects) , ... property services to a wide range of clients in ...
Breaking Biology Technology:Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 4Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 5Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 2Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 3ALNE Announces Intention To Acquire BioTechPharma 2ITRA Global Continues International Expansion in Perth and Brisbane, Australia 2
... brings new ideas, strategies and experience to Wisconsin , ... the process of closing a Venture Capital (VC) fund called ... in what the firm refers to refer to as the ... a $60-million commitment from the State of Wisconsin ...
... The Defense Advanced Research Projects Agency (DARPA), has awarded Alfalight ... DARPA Super High Efficiency Diode Source (SHEDS) program. ... total award of $5.3 million. , , Alfalight , founded ... contract in an appropriations bill passed by Congress bringing their ...
... Has the Wisconsin Economic Summit run its course? With ... that skeptics and supporters alike will ask about the University ... , ,The best answer, to be fair, is wait-and-see. If ... of what has been accomplished over the past three years ...
Cached Biology Technology:West Coast VC Establishes Midwest Presence in Madison 2West Coast VC Establishes Midwest Presence in Madison 3West Coast VC Establishes Midwest Presence in Madison 4West Coast VC Establishes Midwest Presence in Madison 5Alfalight Gets $3.8M From DARPA - Funding has increased to $8.5 Million 2Wisconsin Economic Summit Aims for a New Lease on Life 2
... an ~185 kDa protein, corresponding to the ... tyrosine 1248 on SDS-PAGE immunoblots. The affinity ... the non-phosphorylated peptide to remove antibodies that ... protein. In cell lines where EGFR ...
... Cyclin D2 is a G1 cyclin required ... candidate for a proto-oncogene. cyclin D2 ... and/or cdk6. Species Reactivity: Human, Mouse, ... DCS-3.1 MAb is particularly well suited for ...
Mouse Anti-Human Methyl-CpG binding domain protein 2 (MBD2 Monoclonal Antibody Family: Other Applications: Western Blot...
... Immunogen: ... acids 22-37 SGHKSEEKREKMKRTL Antigen ... G-protein signalling; Antigen Subfamily: ... G-protein signalling Recommended Storage: ...
Biology Products: