Navigation Links
Power-boosting signal in muscle declines with age

As people age, they may have to exercise even harder to get the benefits afforded to younger folk. That's the suggestion of a report in the February issue of the journal Cell Metabolism, published by Cell Press, showing that a signal that gives muscles a kind of metabolic boost in response to exercise is blunted in older animals.

The researchers found that so-called AMP-activated protein kinase (AMPK) slows down in the skeletal muscle of 2-year-old rats relative to 3-month-old rats. A chief regulator of whole-body energy balance, AMPK in skeletal muscle stimulates the oxidation of fatty acids and the production, or biogenesis, of power-producing mitochondria that burn fat and fuel cells, according to the researchers.

The new findings might help to explain "what happens as we age," said Gerald I. Shulman, a Howard Hughes Medical Institute investigator at Yale University School of Medicine.

Earlier studies have shown that, in comparison to 20-year-old adults, even lean and healthy people in their seventies show a higher incidence of fat buildup in their muscle and livers and a deficiency in mitochondrial function, Shulman explained. These metabolic shifts have been implicated in the increased prevalence of insulin resistance and type 2 diabetes that occurs with aging.

"The message of this paper is that, with aging, the AMPK pathway has reduced activity," Shulman said. "So, one probably has to work harder to maintain the same level of fat oxidation and mitochondrial biogenesis in muscle."

The number of mitochondria within muscle largely determines its metabolic capacity. The mitochondrial composition of fibers in different muscles corresponds to the jobs that they do, and muscle can be "reprogrammed" through exercise.

For example, Shulman said, the skeletal muscles of marathon runners typically have much greater mitochondrial content and a greater capacity to burn fat. Those properties can most likely be attribu
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Plants respond similarly to signals from friends, enemies
2. Bound for destruction: Ubiquitination protects against improper Notch signaling
3. Viral protein influences key cell-signaling pathway
4. Researchers find promising cancer-fighting power of synthetic cell-signaling molecule
5. Edible bivalves as a source of human pathogens: signals between vibrios and the bivalve host.
6. Scientists discover that three overlapping signals in embryo help get the backbone right
7. After a time-shift, mixed signals from the circadian clock
8. Researchers make surprise discovery that some neurons can transmit three signals at once
9. Structure-building cell signals also may influence learning and memory
10. Fox Chase study shows that weakened T-cell receptor signals change T-cell lineage
11. Immune systems distress signal tells bacteria when to strike back
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Power boosting signal muscle declines with age

(Date:5/17/2013)... Rutgers, The State University of New Jersey, and City ... formulation called Visikol TM that effectively clears organisms ... in place of chloral hydrate, which is one of ... is tightly regulated by the Drug Enforcement Administration (DEA) ... solutions, or clearing agents, are vital for viewing organisms ...
(Date:5/17/2013)... Why Tibetan antelope can live at elevations of ... research published in Nature Communications , investigators ... evidence that some genetic factors may be associated ... The data in this work will also provide ... biology of other ruminant species. , The Tibetan ...
(Date:5/17/2013)... MD The Federation of American Societies for Experimental ... National Institutes of Health (NIH) funding trends highlighting the ... support critical research. The FASEB analysis follows a May ... Collins, MD, PhD, who testified that the $1.6 billion ... sequestration is "having a substantial impact on the scientific ...
Breaking Biology News(10 mins):New formula invented for microscope viewing, substitutes for federally controlled drug 2New formula invented for microscope viewing, substitutes for federally controlled drug 3The genome sequence of Tibetan antelope sheds new light on high-altitude adaptation 2
... Northridge, CALIF (Jan 4, 2012) Daily doses ... significantly improved menopausal symptoms, including significantly reducing hot ... placebo-controlled study in postmenopausal Japanese women published in ... "It is believed that S-equol, produced ...
... a century, Jerald "Snook" Pataky,s research in the University of ... make important decisions to increase their profitability. His observations ... are featured this month in Plant Disease . ... data from their own lab that tells such ...
... Researchers from North Carolina State University and West Virginia ... air pollutant emissions from some chicken and swine barns, ... possibly generating heat. Specifically, the research team designed, ... biofilter and a heat exchanger to reduce ammonia emissions ...
Cached Biology News:New fermented soy ingredient containing S-equol significantly reduced hot flash frequency 2New fermented soy ingredient containing S-equol significantly reduced hot flash frequency 3New fermented soy ingredient containing S-equol significantly reduced hot flash frequency 4New fermented soy ingredient containing S-equol significantly reduced hot flash frequency 5A quarter of a century of sweet corn observations 2A quarter of a century of sweet corn observations 3New tech removes air pollutants, may reduce energy use in animal ag facilities 2
(Date:5/17/2013)... (PRWEB) May 17, 2013 Tooth decay is ... showing active signs of the disease. The World Health Organization ... nearly 100% of adults have cavities. What are the long-term ... is showing a strong connection between the oral bacterial imbalance ... this disease so rampant, yet it is also 100% preventable? ...
(Date:5/16/2013)... 16, 2013 ISPE ... Myers, CAE, to the newly created position of ... role, Myers will be responsible for stimulating ISPE’s ... strategies, advancing the Society’s Member-led and staff-driven business ... to refine organizational, membership and product marketing. , ...
(Date:5/16/2013)... 2013 In late 2012, Dr. Sarah Hart, ... doctors in China about Appearance Medicine . Although Dr. ... her first trip to lecture in China, and quite a ... Fuzhou, home to 12 and 7 million people respectively. Interest ... at this point in time. As Dr. Hart passed through ...
(Date:5/16/2013)... Cambridge Healthtech Institute will host its fifth ... the Renaissance Waterfront Hotel in Boston, MA. The ... at the current strategies and innovations for optimizing bioprocesses ... in the field will reveal how their work has ... specificity and efficiency. , “In this age of rapid ...
Breaking Biology Technology:Seeing the Future: How a Revolutionary New Bacterial Screening Device Can Predict a Patient’s Future for Tooth Decay 2Seeing the Future: How a Revolutionary New Bacterial Screening Device Can Predict a Patient’s Future for Tooth Decay 3ISPE Names Barbara A. Myers, CAE, as Vice President of Professional Development 2The 2013 Bioprocessing Summit to Bring Together International Leaders to Discuss Today's Bioprocess Issues From Cell Line Selection to Manufacturing in Boston, MA 2
... 30 Amylin Pharmaceuticals, Inc. (Nasdaq: AMLN ) ... shareholder Icahn Capital LP and affiliated funds announcing their intent ... election at the Company,s 2009 annual meeting. The notice ... a proposal for shareholder approval requesting that the Company reincorporate ...
... New research has shown that companies ... collecting and understanding intelligence through the competitive or business ... the best practices in developing effective and legally sound ... Best Practices, LLC, with insights available in the newly ...
... risk factors better than standard cholesterol test and traditional ... Traditional risk factors such as age, standard cholesterol ... predicting heart disease risk in younger, healthy adults with ... to a recent study published in Clinical Cardiology ...
Cached Biology Technology:Amylin Pharmaceuticals Confirms Receipt of Director Nomination Notices 2New Study Shares Insights for Competitive Intelligence Policies, Ethics and Data Collection 2Traditional Risk Factors Often Miss Heart Disease Warning Signs 2Traditional Risk Factors Often Miss Heart Disease Warning Signs 3Traditional Risk Factors Often Miss Heart Disease Warning Signs 4
Mouse monoclonal [3576] to Yellow Fever Virus ( Abpromise for all tested applications). Antigen: Tissue / cell preparation...
... Signet Level 2 Detection System combines ... chemical bonding principle and Signets unique ... sensitivity, specificity and reliablility. Signet reagents ... both manual and automated protocols. ...
6X DNA Gel Loading Buffer is intended for gel electrophoresis of DNA fragments or PCR products....
Agarose Gel Loading Dye Mixture 6X...
Biology Products: