Navigation Links
Potential treatments for neurofibromatosis

Neurofibromatosis can leave its patients miserable and debilitated with chronic itching or pain from disfiguring tumors. Infants affected by the disease face possible paralysis or damage to the brain and other organs.

The disease frustrates doctors because there's no effective treatment even though the responsible gene was identified more than a decade ago. Currently little can be done to treat a disease that affects more people than cystic fibrosis, hereditary muscular dystrophy, Huntington's disease and Tay Sachs combined.

Now, however, research by IU School of Medicine scientist D. Wade Clapp, M.D., and his colleagues David A. Ingram, Jr., M.D. and Feng-Chun Yang, M.D., Ph.D., have identified a promising target to treat the symptoms of neurofibromatosis. They hope to begin preliminary testing in humans by the end of this year, and are experimenting with potential drug compounds now.

Dr. Clapp, professor of pediatrics and of microbiology and immunology, said one target of their efforts will be mast cells, which are immune system cells that are involved in asthma and allergic reactions. Mast cells play a role in neurofibromatosis because they also are involved in blood vessel formation -- and tumors need blood vessels in order to grow.

"We are beginning to have a better understanding of cell to cell interactions that lead to the development of tumors and are poised to answer some of the most perplexing questions that underlie neurofibromatosis," said Dr. Clapp.

"Our work may well be applicable to other types of tumors such as breast and ovarian cancers, because inflammatory cells play an important role in tumor formation in these malignancies."

Neurofibromatosis results from mutations in a gene called NF 1. In humans, NF 1 mutations resulting in neurofibromatosis occur in one in 4,000 births, equally affecting both sexes and all races and ethnicities. It is the most common neurological disorder caused by a single gene.
'"/>

Source:News-Medical.Net


Page: 1 2 3

Related biology news :

1. Novel Enzyme Shows Potential As An Anti-HIV Target
2. Potential Cure for Lymphoma in HIV patients
3. Stem Cell Research Shows Potential for Replacing Tissue Damaged in Heart Attacks
4. Potential Drug Target For Treating Cocaine Abuse Found
5. Potential vaccine developed for deadly leishmaniasis disease
6. Potential heart benefit found in stem cells
7. New understanding of DNA repair may pave way to cancer treatments
8. Researchers discover stem cell guide that may be key for targeting neural stem cell treatments
9. Access to existing medical treatments could save more lives than spending to improve the treatments
10. DNA end caps may lead to cancer treatments, UT Southwestern researchers report
11. New understanding of parasite cell structures may provide treatments for serious tropical diseases
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Potential treatments for neurofibromatosis

(Date:8/6/2015)... 2015  Today, U.S. Congressman Mike Honda ... to learn firsthand how Silicon Valley technologies can ... a world leader in multi-factor identity management and ... federal agencies and commercial organizations achieve new levels ... "The vast majority of network breaches can be ...
(Date:8/5/2015)... MOUNTAIN VIEW, Calif. , Aug. 5, 2015 /PRNewswire/ ... it exhibits continuous growth in applications, penetration into newer ... year after year. The global biosensors space has seen ... having exited the market so far. (Photo ... from Frost & Sullivan, Analysis of the Global ...
(Date:7/31/2015)... de julio de 2015 BGI llevará a cabo ... del 22 al 25 de octubre de 2015, en ... conferencia celebra su décimo aniversario este año. Desde su ... de las reuniones anuales más influyentes del mundo en ... las conferencias científicas más dinámicas, entusiastas y amenas. ...
Breaking Biology News(10 mins):Rep. Honda to Visit Crossmatch in Redwood City 2Innovative Biosensors Incite Use in Non-Traditional Applications 2Innovative Biosensors Incite Use in Non-Traditional Applications 3Innovative Biosensors Incite Use in Non-Traditional Applications 4La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 2La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 3
... A study that relates global energy use to economic ... , finds strong correlations between these two measures both ... leads the study,s authors to infer that energy use ... increase in energy supply will be required to meet ...
... French . Scientists have discovered direct evidence of ... ammonites, distant relatives of squids, octopuses and cuttlefishes. The discovery ... 65.5 million years ago, at the end of the Cretaceous. ... fossils but until now, there has been no experimental evidence ...
... native perennials instead of corn in the Midwest,s rolling ... University research suggests. Federal mandates and market forces ... biologist Bruce Robertson says, but the environmental consequences of ... are a serious concern. Ethanol in America is ...
Cached Biology News:Study finds energy limits global economic growth 2Ammonites' last meal: New light on past marine food chains 2Ammonites' last meal: New light on past marine food chains 3Biofuel grasslands better for birds than ethanol staple corn, researchers find 2
(Date:8/27/2015)... 2015 HUYA Bioscience International (HUYA) today announced the ... Society of HTLV-1, held this week at the University ... the Society is to promote research on HTLV-1 and ... technology and research related to these fields to advance ... is proud to support this prestigious conference," said ...
(Date:8/27/2015)... ... August 27, 2015 , ... Proove Biosciences, ... on the relationship of genetics and hypertension at the International Academy of ... Vancouver, British Columbia, Canada. The event, which boasts an extensive overview of the ...
(Date:8/26/2015)... 26, 2015  The Diabetes Research Institute (DRI), ... Miami Miller School of Medicine, announced today that ... test for the first time a novel transplant ... FDA approved Phase I/II study builds upon decades ... an important first step toward the development of ...
(Date:8/26/2015)... 26, 2015 After litigating and negotiating ... relating to P2i United States patent ... in the United States without any ... of either party. As a result of the parties, settlement, ... California dismissed the case without prejudice. ...
Breaking Biology Technology:HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 2HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 3HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 4Proove Biosciences Presents Ground-Breaking Data on Genetics and Heart Disease at 20th World Congress on Heart Disease 2Proove Biosciences Presents Ground-Breaking Data on Genetics and Heart Disease at 20th World Congress on Heart Disease 3Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 2Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 3Diabetes Research Institute Successfully Transplants First Patient In Pilot BioHub Trial 4P2i Settles United States Litigation 2
... RICHMOND, Calif. , Feb. 3 Sangamo BioSciences, Inc. (Nasdaq: ... accomplishments and provided an outlook for 2010. , For the fourth quarter ... $2.4 million , or $0.05 per share, compared to a ... for the same period in 2008. As of December 31, 2009 , ...
... Feb. 3 The Advisory Board Company (Nasdaq: ... Executive Officer, and Michael T. Kirshbaum , Chief Financial Officer, ... Musslewhite and Mr. Kirshbaum are scheduled to present on Monday, ... the UBS 20th Annual Global Healthcare Services Conference in New ...
... ... testing has committed to holding a spring medical device package testing seminar in March of ... Minneapolis, MN (PRWEB) ... product and material testing , has confirmed that it will host a packaging seminar focused ...
Cached Biology Technology:Sangamo BioSciences Reports Fourth Quarter and Full Year 2009 Financial Results 2Sangamo BioSciences Reports Fourth Quarter and Full Year 2009 Financial Results 3Sangamo BioSciences Reports Fourth Quarter and Full Year 2009 Financial Results 4Sangamo BioSciences Reports Fourth Quarter and Full Year 2009 Financial Results 5Sangamo BioSciences Reports Fourth Quarter and Full Year 2009 Financial Results 6Sangamo BioSciences Reports Fourth Quarter and Full Year 2009 Financial Results 7Sangamo BioSciences Reports Fourth Quarter and Full Year 2009 Financial Results 8Sangamo BioSciences Reports Fourth Quarter and Full Year 2009 Financial Results 9Sangamo BioSciences Reports Fourth Quarter and Full Year 2009 Financial Results 10Sangamo BioSciences Reports Fourth Quarter and Full Year 2009 Financial Results 11Sangamo BioSciences Reports Fourth Quarter and Full Year 2009 Financial Results 12Sangamo BioSciences Reports Fourth Quarter and Full Year 2009 Financial Results 13The Advisory Board Company to Present at Upcoming Conferences 2DDL to Host Spring Packaging Seminar 2