Navigation Links
Potential Drug Target For Treating Cocaine Abuse Found

A substance similar to a drug used in the treatment of Parkinson's disease blocks the stimulating effects of cocaine and could potentially be used to develop drug therapy for cocaine abuse, new research shows.

In an article published in the February 23, 2005, issue of The Journal of Neuroscience, Jonathan Katz and his colleagues at the National Institute on Drug Abuse (NIDA) report the results of experiments showing that mice treated with a substance similar to the drug benztropine did not show any of the typical hyperactive behavior when later injected with cocaine. This effect wore off after a day.

Cocaine produces intense feelings of euphoria by increasing the amount of dopamine that is sent from one neuron to another within the brain reward system. Dopamine signals pleasure and reward by binding to receptors on the receiving neurons, after which it is reabsorbed for later use by a protein that transports it back into the sending neuron. But cocaine blocks the mechanism that transports dopamine, causing it to build up and send an unceasing message of pleasure ?the cocaine high.

Researchers have long searched for "a molecule that would block cocaine's effects on the transporter without inhibiting the transporter by itself," notes Eric Nestler, chair of psychiatry at the University of Texas Southwestern Medical Center in Dallas.

"This article reports early studies with just such a compound." Although the results are preliminary, this breakthrough shows that it may be possible to develop drugs that block cocaine's stimulating effects, and perhaps its power to addict, Nestler says.

Researchers previously thought that different chemicals that prevent the reabsorption of dopamine would all have the same stimulating effect on the brain. The new study shows this may not be true. "In fact, the interaction between dopamine trans-porters and the substances that bind to them may depend on the chemical structure of those substances," say s NIDA's Amy Newman, who synthesized the compound. The researchers found that their novel drug made contact with transporters slowly ?about 10 times slower than cocaine ?which, they speculate, may be why it does not have a stimulating effect.

Between 2 million and 3.2 million people in the United States ?about 1 percent of the population - use cocaine, according to estimates. Of this number, more than 550,000 are crack users. In 2002, 1.5 million Americans were thought to be dependent on or abusing cocaine. "Cocaine is capable of destroying not only the lives of those addicted, but also the lives of those around them," says Katz. "An effective treatment for cocaine addiction would be of immeasurable help to these individuals and their families."


'"/>

Source:Society For Neuroscience


Related biology news :

1. Novel Enzyme Shows Potential As An Anti-HIV Target
2. Potential Cure for Lymphoma in HIV patients
3. Potential treatments for neurofibromatosis
4. Stem Cell Research Shows Potential for Replacing Tissue Damaged in Heart Attacks
5. Potential vaccine developed for deadly leishmaniasis disease
6. Potential heart benefit found in stem cells
7. First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers
8. Affymetrix and ParAllele Launch Industrys Most Comprehensive Product Line for Targeted Genotyping
9. Targeting a key enzyme with gene therapy reversed course of Alzheimers disease in mouse models
10. New Therapeutic Target Identified In Inherited Brain Tumor Disorder
11. Targeted drug delivery achieved with nanoparticle-aptamer bioconjugates
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/13/2016)... physicians supporting Medicaid patients in Central Florida ... telehealth thanks to a new partnership with higi.   ... can routinely track key health measurements, such as blood ... they opt in, share them with IMPOWER clinicians through ... location at no cost. By leveraging this data, IMPOWER ...
(Date:3/22/2016)... March 22, 2016 ... Sensors Market for Consumer Industry by Type (Image, ... Application (Communication & IT, Entertainment, Home Appliances, ... Forecast to 2022", published by MarketsandMarkets, the ... to reach USD 26.76 Billion by 2022, ...
(Date:3/15/2016)... 15, 2016 --> ... Transparency Market Research "Digital Door Lock Systems Market - Global ... 2023," the global digital door lock systems market in terms ... and is forecast to grow at a CAGR of 31.8% ... and medium enterprises (MSMEs) across the world and high industrial ...
Breaking Biology News(10 mins):
(Date:5/26/2016)... ... May 26, 2016 , ... Kinder Scientific ... positive developments that position the Company for the future. Kinder Scientific announces ... F. Kinghorn has been appointed Chairman of the Board, Curtis D. Kinghorn has ...
(Date:5/25/2016)... ... ... Lajollacooks4u has become a rising hotspot for specialized team building events in ... Fortune 500 companies, such as Illumina, Hewlett-Packard, Qualcomm and Elsevier, have traveled from ... Each event kicks off with an olive oil and salt-tasting competition. From there, ...
(Date:5/25/2016)... ... May 25, 2016 , ... The Ankle Plating ... options designed to address fractures of the distal tibia and fibula. This system ... Ankle Plating System 3 is composed of seven plate families that span the ...
(Date:5/25/2016)... Bethesda, Md. (PRWEB) , ... May 25, 2016 ... ... a request for information (RFI) issued by the Office of the National Coordinator ... the patient experience, and determines if clinically relevant data were available when and ...
Breaking Biology Technology: