Navigation Links
Possible brain hormone may unlock mystery of hibernation

The discovery of a possible hibernation hormone in the brain may unlock the mystery behind the dormant state, researchers reported in the April 7, 2006 issue of Cell. Hibernation allows animals from bears to rodents to survive unscathed--in a state of suspended animation--under the harshest of winter conditions.

If the findings in chipmunks are confirmed, the hormone would represent the first essential brain signal governing the seasonal adaptation, according to the researchers.

As hibernation factors endow animals with an incredible ability to cope under otherwise lethal conditions--ratcheting down their metabolic rate to survive on limited energy reserves and withstanding extreme cardiovascular and oxygen stresses--the candidate hormone might also pave the way toward clinical therapies that lend humans the same kind of protection, they added.

The researchers earlier found that concentrations of "hibernation-specific protein" complex (HPc) decline in the blood of hibernating chipmunks. The team now reports evidence that the level of HPc in the brain increases at the onset of hibernation independently of changes in body temperature. Moreover, treatments that block HP activity in the animals' brains cuts hibernation short.

"One of the most curious biological phenomena in mammals is their ability to hibernate circannually, which allows them to survive unusually low body temperatures at or near freezing," said study author Takashi Ohtsu of Kanagawa Academy of Science and Technology in Japan. Scientists have attempted for decades to identify substances responsible for hibernation in the blood and organs of hibernating animals but have met with little success, the researchers said.

"Although the functions of HP remain to be clarified, the current observations lead us to propose the involvement of the protein complex in the regulation of energy metabolism and/or biological defenses during hibernation--crucial events for adapting to t
'"/>

Source:Cell Press


Page: 1 2 3

Related biology news :

1. Stem Cells Found In Cerebellum; Possible Cell of Origin for Childhood Brain Tumors
2. Possible treatment found for chemobrain
3. Is it Possible to Change Prescribing Habits?
4. Possible birthplace of malignant brain tumors identified
5. Controversial drug shown to act on brain protein to cut alcohol use
6. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
7. Mouse brain tumors mimic those in human genetic disorder
8. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
9. First atlas of key brain genes could speed research on cancer, neurological diseases
10. NYU study reveals how brains immune system fights viral encephalitis
11. Stem cells from brain transformed to produce insulin at Stanford
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Possible brain hormone may unlock mystery hibernation

(Date:8/28/2014)... mobile app called TX Invasives is now available from ... of Texas at Austin for identifying harmful non-native plant, ... species in the United States cause about $137 billion ... agricultural crops, clog waterways, kill native plants and more. ... app for reporting where invasive species occur, we,re more ...
(Date:8/28/2014)... an expansion of marine protected areas is needed to ... According to investigators from the Wildlife Conservation Society and ... on saving the largest numbers of species, often at ... difficult-to-replace ecological functions. , Many vital ecological ... that also are food for millions of people. ...
(Date:8/28/2014)... Access to Research Careers) Program has announced the travel ... from October 18 22, 2014 in San Diego, ... entry of students, post doctorates and scientists from underrepresented ... and to encourage the participation of young scientists at ... MARC conferred 16 awards totaling $29,600., The FASEB MARC ...
Breaking Biology News(10 mins):Mobile app makes ID of harmful plants, insects in Texas a snap 2Study finds marine protected areas inadequate for protecting fish and ocean ecology 2
... other non-terminal, debilitating conditions and diseases is both feasible ... such test on the approach in patients with advanced ... edition of the Proceedings of the National Academy of ... the potential to block the destructive inflammation process that ...
... computer scientist Yang Cai is working with NASA's ... Flight Center (GSFC) and the National Oceanic and ... detecting and tracking toxic algae plaguing North American ... monitor dangerous algae and various biochemical anomalies for ...
... integrates connections map data into BiblioSphere , Genomatix ... Advancement of Science (AAAS) today announced an agreement ... Transduction Knowledge Environment into Genomatix's BibliospherePE pathway knowledge ... of the journal Science, developed the Signal Transduction ...
Cached Biology News:Results of world's first gene therapy trial for arthritis show approach safe, feasible 2Results of world's first gene therapy trial for arthritis show approach safe, feasible 3Results of world's first gene therapy trial for arthritis show approach safe, feasible 4Carnegie Mellon cyLab researchers work to develop new red tide monitoring 2Genomatix, AAAS ink agreement 2
(Date:8/28/2014)... a Florida State University research team has led to ... emit white light, and convert photon energy directly to ... butterfly. , Biwu Ma, associate professor in the Department ... of Engineering, created the molecule in a lab about ... his creation has many other unique capabilities. , For ...
(Date:8/28/2014)... PrimeSource Building Products, Inc., a leading ... to support their communication needs with the ... conferencing platform GlobalMeet powered by SoundConnect. The solution ... SoundConnect delivers award winning “results driven” business class ... be utilizing GlobalMeet powered by SoundConnect ...
(Date:8/27/2014)... 27, 2014 Green & Grow Inc. ... B funding and secured Otter Capital as a significant ... accelerate commercialization of GGI’s Agriplier™ technology, building on recent ... , “Since our first meeting, we have been impressed ... product space,” said Alan Sobba, President and CEO of ...
(Date:8/27/2014)... 2014   MSC , a healthcare performance improvement ... the appointment of Mary Beth Loesch to ... of experience preparing companies for rapid growth and market ... President of Corporate Development and Healthcare. In that role, ... as well as corporate strategy and marketing. Previously, Loesch ...
Breaking Biology Technology:Novel 'butterfly' molecule could build new sensors, photoenergy conversion devices 2PrimeSource Chooses SoundConnect as Collaboration Provider 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 3MSC names Mary Beth Loesch President and CEO 2
... , NEW YORK, June 15 NeoStem, Inc. (NYSE ... pre-disease collection, processing and long-term storage of adult stem ... signed an exclusive 10-year agreement with Enhance BioMedical Holdings ... Collection and Treatment Network using NeoStem,s proprietary adult stem ...
... , ... announces new facility which will add capacity, additional capabilities to growing laboratory in order to ... ... new facility which will more than triple the company,s previous capacity and will accommodate projected ...
... ... Positives , ... NY (PRWEB) June 15, 2009 -- iCardiac Technologies, Inc., a leader in advanced cardiac ... a medium sized pharmaceutical company for cardiac safety evaluation comprising multiple Thorough QT (TQT) ...
Cached Biology Technology:NeoStem Signs Agreement with Shanghai Corporation to Develop A Stem Cell Collection and Treatment Network in Shanghai, Taiwan and Other Targeted China Provinces 2NeoStem Signs Agreement with Shanghai Corporation to Develop A Stem Cell Collection and Treatment Network in Shanghai, Taiwan and Other Targeted China Provinces 3NeoStem Signs Agreement with Shanghai Corporation to Develop A Stem Cell Collection and Treatment Network in Shanghai, Taiwan and Other Targeted China Provinces 4CoreRx, Inc. Announces Plans for Expansions to Meet the Needs of Growing Pharmaceutical Formulation Development Business 2iCardiac Selected for Multiple Cardiac Safety Studies 2
Homo sapiens CDC23 (cell division cycle 23, yeast, homolog),...
Terrific Broth, 1 kg. Mixture of casein peptone, yeast extract, K2HPO4, and KH2PO4.Used at 47 g/l for E. coli growth with higher cell densities. Category: Nucleotides & Enzymes & Biochemicals, Ultrap...
(3-[125I]iodotyrosyl26)Galanin (porcine), 925 kBq, 25 uCi. Category: IODINE LIGANDS....
Immunogen: Synthetic peptide based on the sequence: SPSSGPSLTADSMWR Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biology Products: